2-(((4-(4-bromophenyl)-1-(p-tolyl)-1H-1,2,3-triazol-5-yl)imino)methyl)phenol | 1389253-63-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(((4-(4-bromophenyl)-1-(p-tolyl)-1H-1,2,3-triazol-5-yl)imino)methyl)phenol
• CAS: 1389253-63-7
• 化学式: C₂₂H₁₇BrN₄O
• 分子量: 433.307
• InChiKey: MKSVSQPHSRTPEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.46
• 重原子数：
  28.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  63.3
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  p-叠氮甲苯 在 sodium methylate 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 2-(((4-(4-bromophenyl)-1-(p-tolyl)-1H-1,2,3-triazol-5-yl)imino)methyl)phenol
  参考文献：
  名称：

  Design, synthesis and antimicrobial activities of 1,2,3-triazole derivatives

  摘要：

  Fifteen 1-(4-substituted phenyl)-4-(4-bromophenyl)-5-(halo-o-hydroxyphenyl)imino-1,2,3-triazoles were designed and synthesized based on rational combination of 1,2,3-triazoles and (halo)o-hydroxyphenyl group according to the superposition principle of reinforcement of biological activities. All the compounds were tested to an in vitro antimicrobial screening against M.a. and E.c.. Compounds IIe-IIo exhibited more potent antimicrobial activities against M.a. and E.c. than triclosan and fluconazole, which provided valuable information to further study of novel antimicrobial research. (C) 2012 Jun Rui Lu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2012.06.014