Methyl 4-[[6-(cyclopentylcarbamoylamino)indol-1-yl]methyl]-3-methoxybenzoate | 104436-02-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 4-[[6-(cyclopentylcarbamoylamino)indol-1-yl]methyl]-3-methoxybenzoate
• CAS: 104436-02-4
• 化学式: C₂₄H₂₇N₃O₄
• 分子量: 421.496
• InChiKey: KZFZLKSOXZQSKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  81.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl 4-[[6-(cyclopentylcarbamoylamino)indol-1-yl]methyl]-3-methoxybenzoate 在 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 30.0h， 生成 4-[6-(3-环戊基-脲基)-吲哚-1-基甲基]-3-甲氧基-苯甲酸
  参考文献：
  名称：

  Evolution of a series of peptidoleukotriene antagonists: synthesis and structure-activity relationships of 1,6-disubstituted indoles and indazoles

  摘要：

  A perception of structural similarities between two independent series of leukotriene antagonists (one emanating from FPL 55712 and one based upon the leukotrienes themselves) led to the discovery of a novel class of indole and indazole derived antagonists of peptidoleukotrienes. A systematic exploration of C-6 substituted 4-(indol-1-ylmethyl)-3-methoxybenzoic acids identified cyclopentylacetamide and cyclopentylurethane as preferred substituents. The corresponding indazoles were equipotent. These compounds are selective leukotriene antagonists with pKB values of 7.5-7.8 vs LTE4 on guinea pig trachea.

  DOI：

  10.1021/jm00168a036
• 作为产物：
  描述：

  3-甲氧基-4-甲基苯甲酸 在 palladium on activated charcoal 氢气 、 溴 、 potassium carbonate 、 溶剂黄146 、 乙酸乙酯 、 三乙胺 、 乙酰氯 作用下， 以 四氯化碳 、 丙酮 为溶剂， 25.0~80.0 ℃ 、344.73 kPa 条件下， 反应 115.0h， 生成 Methyl 4-[[6-(cyclopentylcarbamoylamino)indol-1-yl]methyl]-3-methoxybenzoate
  参考文献：
  名称：

  Evolution of a series of peptidoleukotriene antagonists: synthesis and structure-activity relationships of 1,6-disubstituted indoles and indazoles

  摘要：

  A perception of structural similarities between two independent series of leukotriene antagonists (one emanating from FPL 55712 and one based upon the leukotrienes themselves) led to the discovery of a novel class of indole and indazole derived antagonists of peptidoleukotrienes. A systematic exploration of C-6 substituted 4-(indol-1-ylmethyl)-3-methoxybenzoic acids identified cyclopentylacetamide and cyclopentylurethane as preferred substituents. The corresponding indazoles were equipotent. These compounds are selective leukotriene antagonists with pKB values of 7.5-7.8 vs LTE4 on guinea pig trachea.

  DOI：

  10.1021/jm00168a036

文献信息

• Evolution of a series of peptidoleukotriene antagonists: synthesis and structure-activity relationships of 1,6-disubstituted indoles and indazoles
  作者：Frederick J. Brown、Ying K. Yee、Laura A. Cronk、Kevin C. Hebbel、Robert D. Krell、David W. Snyder

  DOI：10.1021/jm00168a036

  日期：1990.6

  A perception of structural similarities between two independent series of leukotriene antagonists (one emanating from FPL 55712 and one based upon the leukotrienes themselves) led to the discovery of a novel class of indole and indazole derived antagonists of peptidoleukotrienes. A systematic exploration of C-6 substituted 4-(indol-1-ylmethyl)-3-methoxybenzoic acids identified cyclopentylacetamide and cyclopentylurethane as preferred substituents. The corresponding indazoles were equipotent. These compounds are selective leukotriene antagonists with pKB values of 7.5-7.8 vs LTE4 on guinea pig trachea.