4-chloro-2-[(6-trifluoromethylpyridin-3-ylmethyl)amino]thiazole-5-carbaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-chloro-2-[(6-trifluoromethylpyridin-3-ylmethyl)amino]thiazole-5-carbaldehyde
• 英文别名: 4-Chloro-2-[(6-trifluoromethyl-pyridin-3-ylmethyl)-amino]-thiazole-5-carbaldehyde；4-chloro-2-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]-1,3-thiazole-5-carbaldehyde
• 化学式: C₁₁H₇ClF₃N₃OS
• 分子量: 321.71
• InChiKey: BGMXBFGCOHPKFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  二碳酸二叔丁酯 、 4-chloro-2-[(6-trifluoromethylpyridin-3-ylmethyl)amino]thiazole-5-carbaldehyde 在 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以95%的产率得到(4-chloro-5-formylthiazol-2-yl)(6-trifluoromethylpyridin-3-ylmethyl)carbamic acid tert-butyl ester
  参考文献：
  名称：

  Compounds and methods for kinase modulation, and indications therefor

  摘要：

  描述了化合物及其盐，制剂，共轭物，衍生物，形式和用途。在某些方面和实施方式中，所述的化合物或其盐，制剂，共轭物，衍生物或形式对Fms蛋白激酶，或对Fms和Kit蛋白激酶，或对Fms和Flt-3蛋白激酶具有活性。还描述了使用方法，用于治疗与Fms蛋白激酶，Kit蛋白激酶或Flt-3蛋白激酶活性相关的疾病和状况，包括类风湿性关节炎，骨关节炎，多发性硬化症，阿尔茨海默病，帕金森病，肾小球肾炎，间质性肾炎，狼疮性肾炎，小管坏死，糖尿病肾病，肾肥大，急性髓性白血病，黑色素瘤，多发性骨髓瘤，转移性乳腺癌，前列腺癌，胰腺癌，神经纤维瘤病，脑转移和胃肠间质瘤。

  公开号：

  US09096593B2
• 作为产物：
  描述：

  2,4-二氯噻唑-5-甲醛 、 3-氨甲基-6-(三氟甲基)吡啶 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 以66%的产率得到4-chloro-2-[(6-trifluoromethylpyridin-3-ylmethyl)amino]thiazole-5-carbaldehyde
  参考文献：
  名称：

  Compounds and methods for kinase modulation, and indications therefor

  摘要：

  描述了化合物及其盐，制剂，共轭物，衍生物，形式和用途。在某些方面和实施方式中，所述的化合物或其盐，制剂，共轭物，衍生物或形式对Fms蛋白激酶，或对Fms和Kit蛋白激酶，或对Fms和Flt-3蛋白激酶具有活性。还描述了使用方法，用于治疗与Fms蛋白激酶，Kit蛋白激酶或Flt-3蛋白激酶活性相关的疾病和状况，包括类风湿性关节炎，骨关节炎，多发性硬化症，阿尔茨海默病，帕金森病，肾小球肾炎，间质性肾炎，狼疮性肾炎，小管坏死，糖尿病肾病，肾肥大，急性髓性白血病，黑色素瘤，多发性骨髓瘤，转移性乳腺癌，前列腺癌，胰腺癌，神经纤维瘤病，脑转移和胃肠间质瘤。

  公开号：

  US09096593B2

文献信息

• COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
  申请人：Zhang Jiazhong

  公开号：US20110112127A1

  公开（公告）日：2011-05-12

  Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, or forms thereof are active on Fms protein kinase, or on Fms and Kit protein kinase, or on Fms and Flt-3 protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Fms protein kinase, Kit protein kinase, or Flt-3 protein kinase including rheumatoid arthritis, osteoarthritis, multiple sclerosis, Alzheimer's disease, Parkinson's disease, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, acute myeloid leukemia, melanoma, multiple myeloma, metastatic breast cancer, prostate cancer, pancreatic cancer, neurofibromatosis, brain metastases, and gastrointestinal stromal tumors.

  本文描述了化合物及其盐、制剂、结合物、衍生物、形式和用途。在某些方面和实施方式中，所述化合物或其盐、制剂、结合物、衍生物或形式对Fms蛋白激酶、或对Fms和Kit蛋白激酶、或对Fms和Flt-3蛋白激酶具有活性。还描述了使用它们治疗与Fms蛋白激酶、Kit蛋白激酶或Flt-3蛋白激酶活性相关的疾病和病况的方法，包括类风湿性关节炎、骨关节炎、多发性硬化症、阿尔茨海默病、帕金森病、肾小球肾炎、间质性肾炎、红斑狼疮性肾炎、肾小管坏死、糖尿病肾病、肾肥大、急性髓系白血病、黑色素瘤、多发性骨髓瘤、转移性乳腺癌、前列腺癌、胰腺癌、神经纤维瘤病、脑转移和胃肠道间质肿瘤。
• US9096593B2
  申请人：——

  公开号：US9096593B2

  公开（公告）日：2015-08-04
• [EN] COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR<br/>[FR] COMPOSÉS ET MÉTHODES DE MODULATION DES KINASES ET LEURS INDICATIONS D'EMPLOI
  申请人：PLEXXIKON INC

  公开号：WO2011057022A1

  公开（公告）日：2011-05-12

  Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, or forms thereof are active on Fms protein kinase, or on Fms and Kit protein kinase, or on Fms and Flt-3 protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Fms protein kinase, Kit protein kinase, or Flt-3 protein kinase including rheumatoid arthiritis, osteoarthritis, multiple sclerosis, Alzheimer's disease, Parkinson's disease, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, acute myeloid leukemia, melanoma, multiple myeloma, metastatic breast cancer, prostate cancer, pancreatic cancer, neurofibromatosis, brain metastases, and gastrointestinal stromal tumors.
• Compounds and methods for kinase modulation, and indications therefor
  申请人：Plexxikon Inc.

  公开号：US09096593B2

  公开（公告）日：2015-08-04

  Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, or forms thereof are active on Fms protein kinase, or on Fms and Kit protein kinase, or on Fms and Flt-3 protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Fms protein kinase, Kit protein kinase, or Flt-3 protein kinase including rheumatoid arthritis, osteoarthritis, multiple sclerosis, Alzheimer's disease, Parkinson's disease, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, acute myeloid leukemia, melanoma, multiple myeloma, metastatic breast cancer, prostate cancer, pancreatic cancer, neurofibromatosis, brain metastases, and gastrointestinal stromal tumors.

  描述了化合物及其盐，制剂，共轭物，衍生物，形式和用途。在某些方面和实施方式中，所述的化合物或其盐，制剂，共轭物，衍生物或形式对Fms蛋白激酶，或对Fms和Kit蛋白激酶，或对Fms和Flt-3蛋白激酶具有活性。还描述了使用方法，用于治疗与Fms蛋白激酶，Kit蛋白激酶或Flt-3蛋白激酶活性相关的疾病和状况，包括类风湿性关节炎，骨关节炎，多发性硬化症，阿尔茨海默病，帕金森病，肾小球肾炎，间质性肾炎，狼疮性肾炎，小管坏死，糖尿病肾病，肾肥大，急性髓性白血病，黑色素瘤，多发性骨髓瘤，转移性乳腺癌，前列腺癌，胰腺癌，神经纤维瘤病，脑转移和胃肠间质瘤。