4-[2-cyano-6-(4-hydroxyphenyl)hexyl]benzoic acid | 136780-66-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[2-cyano-6-(4-hydroxyphenyl)hexyl]benzoic acid
• CAS: 136780-66-0
• 化学式: C₂₀H₂₁NO₃
• 分子量: 323.392
• InChiKey: VMWVKCDSYGPRIY-UHFFFAOYSA-N

物化性质

• 沸点：
  597.8±50.0 °C(Predicted)
• 密度：
  1.196±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.19
• 重原子数：
  24.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  81.32
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  4-溴甲基苯甲酸叔丁酯 在 (6-氨基己基氨基)甲基-(二乙氧基甲基)硅 、 四丁基氟化铵 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三氟乙酸 、 碘甲烷 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 4-[2-cyano-6-(4-hydroxyphenyl)hexyl]benzoic acid
  参考文献：
  名称：

  Materials chemistry of chiral macromolecules. 1. Synthesis and phase transitions

  摘要：

  This paper describes work on synthesis of chiral macromolecules as part of a materials chemistry study which seeks to establish links in these systems among molecular structure, three-dimensional molecular organization, and properties. The basic materials chemistry hypothesis driving this work is that chiral forces among stereogenic centers may serve as guiding fields to organize polymers in two or three dimensions. It follows that physical properties could be directly or indirectly controlled by chirality. In order to promote strong forces among chiral centers the chains were designed to have stereogenic carbons substituted by the strongly dipolar cyano group and spaced by 16 atoms along the backbone. The preparative chemistry of chiral macromolecules is challenging given the limited number of polymerization methodologies and the inherent translational periodicity of synthetic polymers. We have synthesized here low symmetry chiral macromolecules in which the only symmetry element retained is polar translation; achiral homologues lacking the nitrile function, the configurationally disordered polymer, and dimeric model compounds were prepared as well. The compounds exhibited crystalline and liquid crystalline phases, and significant differences were observed among homologues through differential scanning calorimetry and optical microscopy. The substitution of nitrile groups every 16 atoms along the polymer backbone, specially with configurational disorder, leads to glassy or less ordered condensed phases. In some Polymers when the strongly dipolar stereogenic centers do not have preferred handedness, chains organize into mesophases rather than crystalline structures. This is surprising since the concentration of stereogenic centers is extremely dilute. Using dimeric model compounds, homochiral recognition among stereogenic centers with large dipole moments was identified as an important factor in the assembly of molecules into layered structures. Interestingly, catenation of the dipolar stereogenic centers in polymeric compounds apparently leads to layered structures even when configurational disorder exists along the polymer backbone. This type of structural control could be extremely useful as an approach to tune physical properties of polymeric materials.

  DOI：

  10.1021/ja00035a041

文献信息

• Materials chemistry of chiral macromolecules. 1. Synthesis and phase transitions
  作者：J. S. Moore、S. I. Stupp

  DOI：10.1021/ja00035a041

  日期：1992.4

  This paper describes work on synthesis of chiral macromolecules as part of a materials chemistry study which seeks to establish links in these systems among molecular structure, three-dimensional molecular organization, and properties. The basic materials chemistry hypothesis driving this work is that chiral forces among stereogenic centers may serve as guiding fields to organize polymers in two or three dimensions. It follows that physical properties could be directly or indirectly controlled by chirality. In order to promote strong forces among chiral centers the chains were designed to have stereogenic carbons substituted by the strongly dipolar cyano group and spaced by 16 atoms along the backbone. The preparative chemistry of chiral macromolecules is challenging given the limited number of polymerization methodologies and the inherent translational periodicity of synthetic polymers. We have synthesized here low symmetry chiral macromolecules in which the only symmetry element retained is polar translation; achiral homologues lacking the nitrile function, the configurationally disordered polymer, and dimeric model compounds were prepared as well. The compounds exhibited crystalline and liquid crystalline phases, and significant differences were observed among homologues through differential scanning calorimetry and optical microscopy. The substitution of nitrile groups every 16 atoms along the polymer backbone, specially with configurational disorder, leads to glassy or less ordered condensed phases. In some Polymers when the strongly dipolar stereogenic centers do not have preferred handedness, chains organize into mesophases rather than crystalline structures. This is surprising since the concentration of stereogenic centers is extremely dilute. Using dimeric model compounds, homochiral recognition among stereogenic centers with large dipole moments was identified as an important factor in the assembly of molecules into layered structures. Interestingly, catenation of the dipolar stereogenic centers in polymeric compounds apparently leads to layered structures even when configurational disorder exists along the polymer backbone. This type of structural control could be extremely useful as an approach to tune physical properties of polymeric materials.