3-(4-acetyl-anilino)-acrylaldehyde-(4-acetyl-phenylimine) | 103596-97-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(4-acetyl-anilino)-acrylaldehyde-(4-acetyl-phenylimine)
• 英文别名: 3-(4-Acetyl-anilino)-acrylaldehyd-(4-acetyl-phenylimin)
• CAS: 103596-97-0
• 化学式: C₁₉H₁₈N₂O₂
• 分子量: 306.364
• InChiKey: NEGLEEIDZZMHIY-ISBOMMPASA-N

物化性质

• 沸点：
  507.6±50.0 °C(Predicted)
• 密度：
  1.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.42
• 重原子数：
  23.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  58.53
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1,1,3,3-四乙氧基丙烷 、 4-氨基苯乙酮 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 3-(4-acetyl-anilino)-acrylaldehyde-(4-acetyl-phenylimine)
  参考文献：
  名称：

  共轭席夫碱基于丙二醛的性质。

  摘要：

  丙二醛是脂质氧化的最终产物之一，由于它具有双功能性，因此可以与伯胺生成共轭席夫碱。研究了丙二醛与苯胺（I1）、对甲苯胺（I2）、对甲氧基苯胺（I3）、对氯苯胺（I4）和对氨基苯乙酮（I5）的共轭席夫碱的荧光特性、与硫代巴比妥酸（TBA）的反应性和抗氧化活性。化合物 I1-I5 没有显示出明显的内在荧光。不稳定的化合物 I5 在二甲基甲酰胺-四正丙基氢氧化铵混合物中产生了高荧光化合物。在 TBA 反应中，化合物 I1-I4 产生的红色不及丙二醛的 30%，而不稳定化合物 I5 产生的红色与丙二醛一样强烈。化合物 I1-I4 与油酸甲酯、猪油和大豆油一起作为抗氧化剂具有活性。

  DOI：

  10.1248/cpb.34.1794

文献信息

• An Immunohistochemical Study of the Distribution of the Measles Virus Receptors, CD46 and SLAM, in Normal Human Tissues and Subacute Sclerosing Panencephalitis
  作者：Stephen McQuaid、Sara Louise Cosby

  DOI：10.1038/labinvest.3780434

  日期：2002.4

  We have compared the expression of the known measles virus (MV) receptors, membrane cofactor protein (CD46) and the signaling lymphocyte-activation molecule (SLAM), using immunohistochemistry, in a range of normal peripheral tissues (known to be infected by MV) as well as in normal and subacute sclerosing panencephalitis (SSPE) brain. To increase our understanding of how these receptors could be utilized by wild-type or vaccine strains in vivo, the results have been considered with regard to the known route of infection and systemic spread of MV. Strong staining for CD46 was observed in endothelial cells lining blood vessels and in epithelial cells and tissue macrophages in a wide range of peripheral tissues, as well as in Langerhans' and squamous cells in the skin. In lymphoid tissues and blood, subsets of cells were positive for SLAM, in comparison to CD46, which stained all nucleated cell types. Strong CD46 staining was observed on cerebral endothelium throughout the brain and also on ependymal cells lining the ventricles and choroid plexus. Comparatively weaker CD46 staining was observed on subsets of neurons and oligodendrocytes. In SSPE brain sections, the areas distant from lesion sites and negative for MV by immunocytochemistry showed the same distribution for CD46 as in normal brain. However, cells in lesions, positive for MV, were negative for CD46. Normal brain showed no staining for SLAM, and in SSPE brain only subsets of leukocytes in inflammatory infiltrates were positive. None of the cell types most commonly infected by MV show detectable expression of SLAM, whereas CD46 is much more widely expressed and could fulfill a receptor function for some wild-type strains. In the case of wild-type stains, which are unable to use CD46, a further as yet unknown receptor(s) would be necessary to fully explain the pathology of MV infection.