5,5,6,6,7,7,8,8,8-九氟辛酸 | 27854-33-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 5,5,6,6,7,7,8,8,8-九氟辛酸
• 英文名称: 5,5,6,6,7,7,8,8,8-Nonafluorooctanoic acid
• CAS: 27854-33-7
• 化学式: C₈H₇F₉O₂
• 分子量: 306.128
• InChiKey: AQGBOPDJGMNAKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  5,5,6,6,7,7,8,8,8-九氟辛酸 在 lithium aluminium tetrahydride 、 三溴化磷 作用下， 以 乙醚 为溶剂， 反应 24.0h， 生成 8-bromo-1,1,1,2,2,3,3,4,4-nonafluoro-octane
  参考文献：
  名称：

  Convenient synthesis of thiols and disulfides in the polyfluorinated series incorporating a butylic spacer

  摘要：

  New fluorinated thiols R-F(CH2)(p)SH and disulfides [R-F(CH2)(p)S](2) containing a butylic spacer (p=4) between the perfluorinated part and the thiol (or disulfide) function were easily obtained in good yields with a purity higher than 98%. This allows us to obtain homologues (p>4) for their use as synthetic intermediates or as constituents for molecular organized systems. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00303-8
• 作为产物：
  描述：

  1,1,2,2-四氢全氟己基碘 在 氢氧化钾 、 potassium carbonate 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 27.0h， 生成 5,5,6,6,7,7,8,8,8-九氟辛酸
  参考文献：
  名称：

  Convenient synthesis of thiols and disulfides in the polyfluorinated series incorporating a butylic spacer

  摘要：

  New fluorinated thiols R-F(CH2)(p)SH and disulfides [R-F(CH2)(p)S](2) containing a butylic spacer (p=4) between the perfluorinated part and the thiol (or disulfide) function were easily obtained in good yields with a purity higher than 98%. This allows us to obtain homologues (p>4) for their use as synthetic intermediates or as constituents for molecular organized systems. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00303-8

文献信息

• Electrochemical fluorination of 4-(perfluoro-n-butyl)-n-butanoyl chloride
  作者：M. Napoli、L. Conte、G.P. Gambaretto、F.M. Carlini

  DOI：10.1016/s0022-1139(00)84147-0

  日期：1989.11

  Electrochemical fluorination of 4-(perfluoro-n-butyl)-n-butanoyl chloride produces perfluorooctanoyl fluoride in higher yields than those obtained from n-octanoyl chloride, which is the usual starting material. In particular, one of the by-products of the industrial process, the cyclic perfluoroether perfluoro-2-propyl-tetrahydropyran, is not formed. Also the other by-products. except fluorocarbon

  4-（全氟-正丁基）-正丁酰氯的化学氟化产生的全氟辛酰氟的产率高于从通常的起始原料正辛酰氯获得的产率。特别地，没有形成工业过程的副产物之一，环状全氟醚全氟-2-丙基-四氢吡喃。还有其他副产品。除了氟碳全氟正庚烷以外，其他产品的产量都较低。讨论了这些结果并提出了一种机制。
• Nouveaux procédés de préparation des isocyanates F-alkylés linéaires ou ramifiés à partir des iodures de 2-F-alkyléthyle
  作者：P. Lucas、M.A. Jouani、H. Trabelsi、A. Cambon

  DOI：10.1016/s0022-1139(98)00235-8

  日期：1998.10

  Isocyanates are extremely versatile compounds in organic synthesis, but their synthesis is not easy. One of the most convenient methods uses acids as intermediates. In the F-alkyl series, it is sometimes difficult to obtain them by a general way. We have managed an efficient synthetic route to F-alkyl acids through malonates from 2-F-alkylethyl iodides.