2',4',6'-Trihydroxy-3,4-dimethoxydihydrochalcone | 124281-55-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2',4',6'-Trihydroxy-3,4-dimethoxydihydrochalcone
• 英文别名: 3-(3,4-dimethoxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-one；3-(3,4-Dimethoxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-on；3-(3,4-Dimethoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
• CAS: 124281-55-6
• 化学式: C₁₇H₁₈O₆
• 分子量: 318.326
• InChiKey: IHEYOUFZWFHEBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2',4',6'-Trihydroxy-3,4-dimethoxydihydrochalcone 生成 5,7-Dihydroxy-3-(3,4-dimethoxybenzyl)chromone
  参考文献：
  名称：

  JAIN, A. C.;PALIWAL, POONAM, INDIAN J. CHEM. B , 28,(1989) N, C. 416-418

  摘要：

  DOI：
• 作为产物：
  描述：

  4'-甲基金圣草黄素 生成 2',4',6'-Trihydroxy-3,4-dimethoxydihydrochalcone
  参考文献：
  名称：

  Massicot et al., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1954, vol. 238, p. 111

  摘要：

  DOI：

文献信息

• DIARYLALKANES AS POTENT INHIBITORS OF BINUCLEAR ENZYMES
  申请人：Unigen, Inc.

  公开号：US20160193126A1

  公开（公告）日：2016-07-07

  The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

  本发明实施了一种策略，将酶抑制测定与化学去重过程相结合，以识别活性植物提取物和特定化合物——二芳基烷烃和/或二芳基烷醇，这些化合物特异性地抑制双核酶功能。本发明包括由一种或多种二芳基烷烃和/或二芳基烷醇组成的物质组成，这些化合物抑制双核酶的活性，特别是酪氨酸酶，从而防止黑色素过度生产。本发明还提供了一种抑制双核酶活性的方法，特别是酪氨酸酶的方法，以及一种预防和治疗与双核酶功能有关的疾病和病况的方法。本发明进一步包括一种预防和治疗黑色素过度生产以及与之相关的皮肤疾病和病况的方法。预防和治疗与双核酶功能和黑色素过度生产有关的疾病和病况的方法包括向需要的宿主投与一种或多种二芳基烷烃和/或二芳基烷醇的有效量，这些化合物从一种或多种植物中合成和/或分离，并与药用载体一起使用。
• Diarylalkanes as potent inhibitors of binuclear enzymes
  申请人：Unigen, Inc.

  公开号：US10548825B2

  公开（公告）日：2020-02-04

  The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

  本发明实施了一种将酶抑制测定与化学去复制过程相结合的策略，以确定活性植物提取物和这些提取物中专门抑制双核酶功能的特定化合物-二芳基烷烃和/或二芳基烷醇。本发明包括由一种或多种二芳基烷烃和/或二芳基烷醇组成的物质组合物，可抑制双核酶，特别是酪氨酸酶的活性，防止黑色素过度生成。本发明还提供了一种抑制双核酶，特别是酪氨酸酶活性的方法，以及一种预防和治疗与双核酶功能有关的疾病和病症的方法。本发明还包括一种预防和治疗黑色素过度生成以及与此相关的皮肤疾病和病症的方法。预防和治疗与双核酶功能和黑色素过度产生有关的疾病和病症的方法包括向有需要的宿主施用有效量的组合物，该组合物包含一种或多种二芳基烷和/或二芳基烷醇，这些二芳基烷和/或二芳基烷醇是从一种或多种植物中合成和/或分离出来的，同时还包含药学上可接受的载体。
• New homoisoflavonoid analogues protect cells by regulating autophagy
  作者：Li-She Gan、Lin-Wei Zeng、Xiang-Rong Li、Chang-Xin Zhou、Jie Li

  DOI：10.1016/j.bmcl.2017.01.086

  日期：2017.3

  As a special group of naturally occurring flavonoids, homoisoflavonoids have been discovered as active components of several traditional Chinese medicines for nourishing heart and mind. In this study, twenty homoisoflavonoid analogues, including different substitution groups on rings A and B, as well as heteroaromatic B ring, were synthesized and evaluated for their cardioprotective and neuroprotective activities. In a H2O2-induced H9c2 cardiomyocytes injury assay, nine homoisoflavonoid analogues showed promising activities in the same level as the positive control, diazoxide. Six cardioprotective compounds with representative structure diversities were then evaluated for their neuroprotective effects on MPP+ induced SH-SY5Y cell injury model. Furthermore, autophagy inducing monodansylcadaverine (MDC) fluorescence staining methods and molecular docking studies indicated the action mechanism of these compounds may involve autophagy regulating via class I P13K signaling pathway. (C) 2017 Elsevier Ltd. All rights reserved.
• Jain, A. C.; Paliwal, Poonam, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1989, vol. 28, # 1-11, p. 416 - 418
  作者：Jain, A. C.、Paliwal, Poonam

  DOI：——

  日期：——
• JAIN, A. C.;PALIWAL, POONAM, INDIAN J. CHEM. B , 28,(1989) N, C. 416-418
  作者：JAIN, A. C.、PALIWAL, POONAM

  DOI：——

  日期：——