1-[4-(4,4-dimethyl-5H-1,3-oxazol-2-yl)phenyl]ethanone | 109660-10-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-(4,4-dimethyl-5H-1,3-oxazol-2-yl)phenyl]ethanone
• CAS: 109660-10-8
• 化学式: C₁₃H₁₅NO₂
• 分子量: 217.268
• InChiKey: AVQXLDVXFZDEJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,4-二甲基-2-氧唑啉 在 四(三苯基膦)钯 正丁基锂 、 三甲基氯化锡 作用下， 以 乙醚 为溶剂， 反应 18.0h， 生成 1-[4-(4,4-dimethyl-5H-1,3-oxazol-2-yl)phenyl]ethanone
  参考文献：
  名称：

  Masked multifunctionalization of aromatics by palladium-catalyzed halogen-oxazoline exchange

  摘要：

  DOI：

  10.1016/s0040-4039(00)85187-4

文献信息

• Palladium-Catalyzed Coupling of Oxazol-2-yl- and 2-Oxazolin-2-yltrimethylstannanes with Aromatic Halides. A New Entry to 2-Aryl and 2-Heteroaryl Oxazoles and Oxazolines
  作者：Alessandro Dondoni、Giancarlo Fantin、Marco Fogagnolo、Alessandro Medici、Paola Pedrini

  DOI：10.1055/s-1987-28047

  日期：——

  4-Methyloxazole and 4,4-dimethyl-2-oxazoline were treated with n-butyllithium and trimethyltin chloride to give the corresponding 2-trimethylstannyl derivatives which in the presence of tetrakis(triphenylphosphine)palladium(0) as a catalyst undergo cross-coupling reactions with various aryl and heteroaryl halides to give 2-aryl and 2-heteroaryl oxazoles and oxazolines in high yields.

  4-甲基恶唑和4,4-二甲基-2-恶唑啉用正丁基锂和三甲基氯化锡反应得到相应的2-三甲基甲锡烷基衍生物，在四(三苯基膦)钯(0)催化剂存在下发生交叉偶联与各种芳基和杂芳基卤化物反应，以高产率得到2-芳基和2-杂芳基恶唑和恶唑啉。
• AZETIDINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS
  申请人：Davenport Adam James

  公开号：US20120040952A1

  公开（公告）日：2012-02-16

  The invention relates to compounds of formula (I), wherein R, R 1 , m, n and X 1 to X 3 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.

  该发明涉及式（I）的化合物，其中R、R1、m、n和X1至X3的含义如描述和权利要求中所述。所述化合物可用作组胺H3受体拮抗剂。该发明还涉及制药组合物、制备此类化合物以及作为药物的生产和使用。
• CHROMAN DERIVATIVES AS TRPM8 INHIBITORS
  申请人：AMGEN INC.

  公开号：US20150031668A1

  公开（公告）日：2015-01-29

  Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

  公式I的铬化合物和衍生物是TRPM8的有用抑制剂。这些化合物可用于治疗许多TRPM8介导的疾病和情况，并可用于制备用于治疗这些疾病和情况的药物和制剂。这些疾病的例子包括但不限于偏头痛和神经病性疼痛。公式I的化合物具有以下结构：其中变量的定义在此提供。
• DONDONI A.; FOGAGNOLO M.; FANTIN G.; MEDICI A.; PEDRINI P., TETRAHEDRON LETT., 27,(1986) N 43, 5269-5270
  作者：DONDONI A.、 FOGAGNOLO M.、 FANTIN G.、 MEDICI A.、 PEDRINI P.

  DOI：——

  日期：——
• DONDONI, A.;FANTIN, G.;FOGAGNOLO, M.;MEDICI, A.;PEDRINI, P., SYNTHESIS,(1987) N 8, 693-696
  作者：DONDONI, A.、FANTIN, G.、FOGAGNOLO, M.、MEDICI, A.、PEDRINI, P.

  DOI：——

  日期：——