2-(4-bromophenyl)-3,4-dihydroisoquinolin-2-ium bromide | 97379-30-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢异喹啉
• 英文名称: 2-(4-bromophenyl)-3,4-dihydroisoquinolin-2-ium bromide
• 英文别名: 2-(4-Bromophenyl)-3,4-dihydroisoquinolin-2-ium;bromide；2-(4-bromophenyl)-3,4-dihydroisoquinolin-2-ium;bromide
• CAS: 97379-30-1
• 化学式: Br*C₁₅H₁₃BrN
• 分子量: 367.083
• InChiKey: AJQPKXORYJXCOT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.77
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-bromophenyl)-3,4-dihydroisoquinolin-2-ium bromide 在 5%-palladium/activated carbon 作用下， 以 水 、 甲苯 、 乙腈 为溶剂， 反应 48.0h， 以76%的产率得到2-(4-bromophenyl)isoquinolin-2-ium bromide
  参考文献：
  名称：

  Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase

  摘要：

  As simple analogues of the natural compound chelerythrine, a novel anti-cholinesterase 2-phenylisoquinolin-2-ium scaffold was designed by structure imitation. The activity evaluation led to the discovery of seven compounds with potent anti-acetylcholinesterase activity with IC50 values of <= 0.72 mu M, superior to chelerythrine and standard drugs galantamine. Particularly, compound 8y showed the excellent dual acetylcholinesterase-butyrylcholinesterase inhibition activity, superior to rivastigmine, a dual cholinesterase inhibitor drug. Furthermore, the compounds displayed a competitive anti-acetylcholinesterase mechanism with the substrate and low cytotoxicity. Molecular docking showed that the isoquinoline moiety is embedded in a cavity surrounded by four aromatic residues of acetylcholinesterase by the pi-pi action. Structure-activity relationship showed that the p-substituents on the C-ring can dramatically improve the anti-acetylcholinesterase activity, while 8-OMe can increase the activity against the two cholinesterases simultaneously. Thus, the title compounds emerged as promising lead compounds for the development of novel cholinesterase inhibitor agents. (C) 2020 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2020.112415
• 作为产物：
  描述：

  异色满 在 copper(II) choride dihydrate 、 氢溴酸 、 氢碘酸 、 氧气 、 sodium dodecyl-sulfate 、 碳酸氢钠 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 11.0h， 生成 2-(4-bromophenyl)-3,4-dihydroisoquinolin-2-ium bromide
  参考文献：
  名称：

  Synthesis of 2-Aryl-3,4-dihydroisoquinolin-2-ium Bromides and Their <i>in Vitro</i> Acaricidal Activity against <i>Psoroptes cuniculi</i>

  摘要：

  通过使用天然活性季铵类异喹啉生物碱——血根碱（sanguinarine）作为模型分子，设计合成了一系列结构简单的季铵类2-芳基-3,4-二氢异喹啉-2-锗化合物，并评估了其对兔毛滴虫（P. cuniculi）的体外杀螨活性。开发了一种以异喹啉为起始材料的新方法。结果显示，在24个测试化合物中，有22个在0.4 mg/mL浓度下显示出不同程度的活性。14个化合物的效果显著优于标准杀螨剂伊维菌素（ivermectin）和血根碱的衍生物6-甲氧基二氢血根碱（6-methoxy dihydrosanguinarine）（p<0.05）。它们的综合相对活性是伊维菌素的1.4到16.5倍，6-甲氧基二氢血根碱的1.5到18.8倍。结构-活性关系表明，在N-苯环上引入取代基，尤其是卤素原子和三氟甲基基团，会显著提高活性。氟原子、甲基和羟基的位置对活性也有非常显著的影响。结论是，2-芳基-3,4-二氢异喹啉-2-锗化合物是开发新型异喹啉杀螨剂的有前景的候选者。

  DOI：

  10.1248/cpb.c12-00876

文献信息

• One-pot functionalisation of <i>N</i>-substituted tetrahydroisoquinolines by photooxidation and tunable organometallic trapping of iminium intermediates
  作者：Joshua P Barham、Matthew P John、John A Murphy

  DOI：10.3762/bjoc.10.316

  日期：——

  stabilised carbon nucleophiles. The few reports of organometallic additions have limited scope of substrate and organometallic nucleophile. We report a novel, one-pot methodology that functionalises N-substituted tetrahydroisoquinolines by visible light-assisted photooxidation, followed by trapping of the resultant iminium ions with organometallic nucleophiles. This affords 1,2-disubstituted tetrahydroisoquinolines

  通过稳定的碳亲核试剂已经很好地确立了通过叔胺的氧化功能化生成的亚胺盐的亲核捕获。关于有机金属添加物的报道很少，限制了底物和有机金属亲核试剂的范围。我们报告了一种新颖的一锅法，通过可见光辅助的光氧化功能化N-取代的四氢异喹啉，然后用有机金属亲核试剂捕获所得的亚胺离子。这以中等至优异的产率提供了1，2-二取代的四氢异喹啉。
• 2-(Substituted phenyl)-3,4-dihydroisoquinolin-2-iums as Novel Antifungal Lead Compounds: Biological Evaluation and Structure-Activity Relationships
  作者：Zhe Hou、Rui Yang、Cen Zhang、Li-Fei Zhu、Fang Miao、Xin-Juan Yang、Le Zhou

  DOI：10.3390/molecules180910413

  日期：——

  The title compounds are a class of structurally simple analogues of quaternary benzo[c]phenanthridine alkaloids (QBAs). In order to develop novel QBA-like antifungal drugs, in this study, 24 of the title compounds with various substituents on the N-phenyl ring were evaluated for bioactivity against seven phytopathogenic fungi using the mycelial growth rate method and their SAR discussed. Almost all the compounds showed definite activities in vitro against each of the test fungi at 50 μg/mL and a broad antifungal spectrum. In most cases, the mono-halogenated compounds 2–12 exhibited excellent activities superior to the QBAs sanguinarine and chelerythrine. Compound 8 possessed the strongest activities on each of the fungi with EC50 values of 8.88–19.88 µg/mL and a significant concentration-dependent relationship. The SAR is as follows: the N-phenyl group is a high sensitive structural moiety for the activity and the characteristics and position of substituents intensively influence the activity. Generally, electron-withdrawing substituents remarkably enhance the activity while electron-donating substituents cause a decrease of the activity. In most cases, ortha- and para-halogenated isomers were more active than the corresponding m-halogenated isomers. Thus, the title compounds emerged as promising lead compounds for the development of novel biomimetic antifungal agrochemicals. Compounds 8 and 2 should have great potential as new broad spectrum antifungal agents for plant protection.

  标题化合物是一类四价苯并[c]菲啶生物碱（QBAs）的结构简单的类似物。为了开发新型的类似QBA的抗真菌药物，本研究评估了24种在N-苯基环上具有不同取代基的标题化合物，对七种植物病原真菌的生物活性进行测试，采用菌丝生长速率法，并讨论了其结构活性关系（SAR）。几乎所有化合物在50 μg/mL的浓度下，对每种测试真菌均显示出明显的体外活性，并且具有广泛的抗真菌谱。在大多数情况下，单卤化化合物2–12的活性优于QBAs中的血根碱和美根草碱。化合物8对每种真菌的活性最强，EC50值为8.88–19.88 µg/mL，且显示出显著的浓度依赖性关系。SAR如下：N-苯基基团是影响活性的高度敏感结构部分，取代基的特性和位置对活性有显著影响。通常，电子吸引取代基显著增强活性，而电子供给取代基则导致活性降低。在大多数情况下，邻位和对位卤化异构体的活性高于相应的间位卤化异构体。因此，标题化合物被认为是开发新型仿生抗真菌农药的有希望的先导化合物。化合物8和2在植物保护作为新的广谱抗真菌剂方面具有很大的潜力。
• Isothiourea-Catalyzed Enantioselective Addition of 4-Nitrophenyl Esters to Iminium Ions
  作者：Jude N. Arokianathar、Aileen B. Frost、Alexandra M. Z. Slawin、Darren Stead、Andrew D. Smith

  DOI：10.1021/acscatal.7b02697

  日期：2018.2.2

  alternative aryl esters, with the observed enantioselectivity markedly dependent on the nature of the iminium counterion. Highest yields and enantioselectivity were obtained using iminium bromide ions generated in situ via photoredox catalysis using BrCCl3 and Ru(bpy)3Cl2 (0.5 mol %) and commercially available tetramisole (5 mol %) as the Lewis base catalyst. The scope and limitations of this procedure

  异硫脲催化将4-硝基苯基酯对映选择性加成到四氢异喹啉衍生的亚胺离子上。由4-硝基苯基酯由异硫脲的初始N-酰化反应原位产生的4-硝基苯氧化物可用于促进该反应过程中的催化剂转化。优化表明，在一系列替代芳基酯中，4-硝基苯基酯在该方案中具有最佳反应性，观察到的对映选择性明显取决于亚胺抗衡离子的性质。使用BrCCl 3和Ru（bpy）3 Cl 2通过光氧化还原催化原位产生的溴化亚胺离子获得最高的收率和对映选择性（0.5mol％）和市售的四咪唑（5mol％）作为路易斯碱催化剂。研究了该方法的范围和局限性，从而以高达96％的收率，79：21的非对映异构体比率（dr）和主要（2 R，1'S） 99.5：0.5给出了所需的β-氨基酰胺产物。
• A Class of Promising Acaricidal Tetrahydroisoquinoline Derivatives: Synthesis, Biological Evaluation and Structure-Activity Relationships
  作者：Rui Yang、Qiao Ruan、Bing-Yu Zhang、Zuo-Lue Zheng、Fang Miao、Le Zhou、Hui-Ling Geng

  DOI：10.3390/molecules19068051

  日期：——

  positions, the order of the activity was ortho > meta > para. It was concluded that the target compounds represent a class of novel promising candidates or lead compounds for the development of new tetrahydroisoquinoline acaricidal agents.

  作为我们对异喹啉杀螨药物的持续研究的一部分，本文报道了一系列在 N-苯环上具有各种取代基的 2-芳基-1-氰基-1,2,3,4-四氢异喹啉的制备，它们在体外对 Psoroptes cuniculi（一种疥螨）的杀螨活性，并讨论了它们的 SAR。通过UV、IR、NMR、ESI-MS、HR-MS光谱和X射线衍射实验分析了所有化合物的结构，包括12个新化合物。所有目标化合物在 0.4 mg/mL 时都显示出不同程度的活性。化合物 1 显示出最强的活性，50% 致死浓度值 (LC50) 为 0.2421 μg/mL，50% 致死时间值 (LT50) 为 7.79 h，与标准药物伊维菌素相当（LC50 = 0.2474 μg/mL；LT50 = 20.9 小时）。SAR表明N-芳环上的取代模式对活性产生显着影响。取代基 2'-F、3'-F、2'-Cl、2'-Br 和 2'-CF3 显着增强了活性。通
• CBr₄ as a Mild Oxidant‐Enabled Oxidation of a <i>sp</i>^<i>3</i> C−H Bond: A Facile Synthesis of the Persistent Iminium Salts of Tetrahydroisoquinolines
  作者：Yuqin Chen、Shuwei Zhang、Yuemei Li、Tong Li、Qiyuan Ma、Yu Yuan、Xiaodong Jia

  DOI：10.1002/chem.202303952

  日期：2024.3.7

  A C−H bond oxidation of THIQs was achieved by CBr4 initiated reaction conditions, providing a series of the persistent iminium salts of THIQs in high yields with good functional group tolerance. These iminium salts can be readily applied to the synthesis of the functionalized THIQ derivatives.

  THIQs的AC−H键氧化是通过CBr 4引发的反应条件实现的，以高产率提供了一系列具有良好官能团耐受性的持久性THIQs亚胺盐。这些亚胺盐可以很容易地应用于官能化 THIQ 衍生物的合成。