诺斯卡品杂质2 | 20276-45-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢异喹啉
• 中文名称: 诺斯卡品杂质2
• 英文名称: Cotarninium
• 英文别名: 4-methoxy-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium
• CAS: 20276-45-3
• 化学式: C12H14NO3+
• mdl: MFCD01547776
• 分子量: 220.24
• InChiKey: KGZAOSLMBZSSTE-UHFFFAOYSA-N

物化性质

• 熔点：
  188-190°C
• 溶解度：
  氯仿（微溶）、甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

文献信息

• Method of inhibiting tau phosphorylation
  申请人：Wang Hoau-Yan

  公开号：US10017736B2

  公开（公告）日：2018-07-10

  A method of inhibiting phosphorylation of the tau protein and/or a TLR4-mediated immune response is disclosed. The method contemplates administering to cells in recognized need thereof such as cells of the central nervous system an effective amount of a of a compound or a pharmaceutically acceptable salt thereof that binds to a pentapeptide of filamin A (FLNA) of SEQ ID NO: 1, and contains at least four of the six pharmacophores of FIGS. 35-40.

  本发明公开了一种抑制 tau 蛋白磷酸化和/或 TLR4 介导的免疫反应的方法。该方法考虑向有公认需要的细胞如中枢神经系统细胞施用有效量的化合物或其药学上可接受的盐，该化合物或其药学上可接受的盐与 SEQ ID NO: 1 的丝胺 A (FLNA) 五肽结合，并包含图 35-40 六种药效团中的至少四种。
• AUFHELLMITTEL MIT KATIONISCHEN 3,4-DIHYDROISOCHINOLINIUMDERIVATEN UND WASSERSTOFFPEROXID
  申请人：Henkel AG & Co. KGaA

  公开号：EP2192957A1

  公开（公告）日：2010-06-09
• AUFHELLMITTEL MIT KATIONISCHEN 3,4-DIHYDROISOCHINOLINIUMDERIVATEN, SPEZIELLEN ALKANOLAMINEN UND WASSERSTOFFPEROXID
  申请人：Henkel AG & Co. KGaA

  公开号：EP2274056B1

  公开（公告）日：2012-10-03
• NOVEL ANALGESIC THAT BINDS FILAMIN A
  申请人：Barbier Lindsay Burns

  公开号：US20100280061A1

  公开（公告）日：2010-11-04

  A compound, composition and method are disclosed that can bind to FLNA and provide analgesia. A contemplated compound has a structure that corresponds to Formula I, wherein R 1 and R 2 are substituents on W that is a ring structure, R 3 and R 4 are substituents on the depicted nitrogen atom, m, n and the dotted lines are all defined within.
• ALZHEIMER'S DISEASE ASSAY IN A LIVING PATIENT
  申请人：WANG HOAU-YAN

  公开号：US20140017698A1

  公开（公告）日：2014-01-16

  An assay for Alzheimer's disease (AD) pathology in a living patient is disclosed wherein an amount of α7nAChR or TLR4 in a FLNA-captured protein complex or α7nAChR in an Aβ-captured protein complex or α7nAChR-FLNA, or TLR4-FLNA and/or α7nAChR-Aβ 42 complex present as a protein-protein complex in a sample is compared to the amount in a standard sample from a person free of AD pathology. An amount greater than in the standard sample indicates AD pathology. Also disclosed is an assay predictive of prognosis for treatment with a medicament in which the amount of an above protein or protein complex is compared to an amount in the presence of a medicament that binds to a FLNA pentapeptide and contains at least four pharmacophores of FIGS. 7 - 12 . An amount of protein or protein complex determined in the presence of medicament that is less than the first amount indicates a favorable treatment prognosis.