pyroglutamyl-phenylalanyl-phenylalanine-glycyl-leucyl-methionine amide | 61123-13-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: pyroglutamyl-phenylalanyl-phenylalanine-glycyl-leucyl-methionine amide
• 英文别名: 6>SP_6-11；pGln-Phe-Phe-Gly-Leu-Met-NH2；[pGlu(6)]-substance P(6-11)；Glp-Phe-Phe-Gly-Leu-MetNH2；pGlu-Phe-Phe-Gly-Leu-Met-NH₂；(p-Glu⁶)SP_6-11；Substance P, C-terminal pentapeptide；(2S)-N-[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-5-oxopyrrolidine-2-carboxamide
• CAS: 61123-13-5
• 化学式: C₃₆H₄₉N₇O₇S
• 分子量: 723.894
• InChiKey: CTTLAZLIKHEYJW-ZIUUJSQJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  51
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.472
• 拓扑面积：
  243
• 氢给体数：
  7
• 氢受体数：
  8

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : [pGlu6]-Substance P Fragment 6-11
CAS-No. : 61123-13-5

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Label elements
The product does not need to be labelled in accordance with EC directives or respective national laws.
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Synonyms : pGlu-Phe-Phe-Gly-Leu-Met-NH2
Formula : C36H49N7O7S
Molecular Weight : 723,88 g/mol

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Section 4. FIRST AID MEASURES
Description of first aid measures
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact
Wash off with soap and plenty of water.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water.
Most important symptoms and effects, both acute and delayed
Substance P acts as a vasodilator, a depressant, stimulates salivation, and produces increased capillary
permeability. It is also capable of producing both analgesia and hyperalgesia in animals.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx), Sulphur oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing vapors, mist or gas.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Sweep up and shovel. Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: -20 °C
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
General industrial hygiene practice.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards
such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Choose body protection in relation to its type, to the concentration and amount of dangerous
substances, and to the specific work-place., The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection is not required. Where protection from nuisance levels of dusts are desired,
use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Pepsin, chymotrypsin.
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion May be harmful if swallowed.
Skin May be harmful if absorbed through skin. May cause skin irritation.
Eyes May cause eye irritation.
Signs and Symptoms of Exposure
Substance P acts as a vasodilator, a depressant, stimulates salivation, and produces increased capillary
permeability. It is also capable of producing both analgesia and hyperalgesia in animals.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  pyroglutamyl-phenylalanyl-phenylalanine-glycyl-leucyl-methionine amide 在 水 、 1-羟基苯并三唑 、 钯 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 25.0h， 生成 pGlu-Gln-Phe-Phe-Gly-Leu-Met.NH2
  参考文献：
  名称：

  Sivanandaiah, K. M.; Rangaraju, N. S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1986, vol. 25, p. 787 - 792

  摘要：

  DOI：
• 作为产物：
  描述：

  苯丙氨酰苯基丙氨酸甲酯 在 sodium hydroxide 、 1-羟基苯并三唑 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 33.5h， 生成 pyroglutamyl-phenylalanyl-phenylalanine-glycyl-leucyl-methionine amide
  参考文献：
  名称：

  Lipkowski, Andrzej W.; Majewski, Tadeusz; Drabarek, Stefania, Polish Journal of Chemistry, 1980, vol. 54, # 9, p. 1707 - 1712

  摘要：

  DOI：

文献信息

• Activity of the C-terminal part of substance P on guinea pig ileum and trachea preparations I. N-acylated pentapeptides SP(7–11)
  作者：Robert Michelot、Michel Mayer、Sylviane Magneney、Paul Pham Van Chuong、Pascal Schmitt、Pierre Potier

  DOI：10.1016/0223-5234(88)90006-2

  日期：1988.5
• Janecka, Anna; Koziolkiewicz, Wiktor; Wasiak, Tadeusz, Polish Journal of Chemistry, 1987, vol. 61, # 7-12, p. 761 - 765
  作者：Janecka, Anna、Koziolkiewicz, Wiktor、Wasiak, Tadeusz

  DOI：——

  日期：——
• MICHELOT, ROBERT;MAYER, MICHEL;MAGNENEY, SYLVIANE;PHAM, VAN CHUONG PAUL;S+, EUR. J. MED. CHEM., 23,(1988) N 3, C. 243-247
  作者：MICHELOT, ROBERT、MAYER, MICHEL、MAGNENEY, SYLVIANE、PHAM, VAN CHUONG PAUL、S+

  DOI：——

  日期：——
• Sivanandaiah, K. M.; Rangaraju, N. S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1986, vol. 25, p. 787 - 792
  作者：Sivanandaiah, K. M.、Rangaraju, N. S.

  DOI：——

  日期：——
• Lipkowski, Andrzej W.; Majewski, Tadeusz; Drabarek, Stefania, Polish Journal of Chemistry, 1980, vol. 54, # 9, p. 1707 - 1712
  作者：Lipkowski, Andrzej W.、Majewski, Tadeusz、Drabarek, Stefania

  DOI：——

  日期：——