3-(Methoxymethoxy)-2-methylpyran-4-one | 181647-78-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 3-(Methoxymethoxy)-2-methylpyran-4-one
• CAS: 181647-78-9
• 化学式: C₈H₁₀O₄
• 分子量: 170.165
• InChiKey: XWPHWRPKWLJIJU-UHFFFAOYSA-N

物化性质

• 沸点：
  311.5±42.0 °C(Predicted)
• 密度：
  1.17±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(Methoxymethoxy)-2-methylpyran-4-one 在 盐酸 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 92.0h， 生成 1-benzyl-3-hydroxy-2-methyl-4-pyridone
  参考文献：
  名称：

  3-Hydroxy-4-pyrones as Precursors of 4-Methoxy-3-oxidopyridinium Ylides. An Expeditious Entry to Highly Substituted 8-Azabicyclo[3.2.1]octanes

  摘要：

  3-Hydroxy-4-pyridones, which are easily prepared from commercially available 3-hydroxy-4-pyrones, can be readily transformed into 4-methoxy-3-oxidopyridinium ylides by treatment with methyl trifluoromethanesulfonate and subsequent deprotonation with a non-nucleophilic base. These ylides are capable of undergoing cycloaddition to several electron-deficient alkenes, thus allowing the synthesis of highly functionalized azabicyclo[3.2,1]octane moieties. The rich substitution patterns of these frameworks might allow their divergent conversion to a variety of natural and non-natural tropane alkaloids.

  DOI：

  10.1021/jo960854v
• 作为产物：
  描述：

  麦芽醇 、 氯甲基甲基醚 在 二异丙胺 作用下， 以94%的产率得到3-(Methoxymethoxy)-2-methylpyran-4-one
  参考文献：
  名称：

  3-Hydroxy-4-pyrones as Precursors of 4-Methoxy-3-oxidopyridinium Ylides. An Expeditious Entry to Highly Substituted 8-Azabicyclo[3.2.1]octanes

  摘要：

  3-Hydroxy-4-pyridones, which are easily prepared from commercially available 3-hydroxy-4-pyrones, can be readily transformed into 4-methoxy-3-oxidopyridinium ylides by treatment with methyl trifluoromethanesulfonate and subsequent deprotonation with a non-nucleophilic base. These ylides are capable of undergoing cycloaddition to several electron-deficient alkenes, thus allowing the synthesis of highly functionalized azabicyclo[3.2,1]octane moieties. The rich substitution patterns of these frameworks might allow their divergent conversion to a variety of natural and non-natural tropane alkaloids.

  DOI：

  10.1021/jo960854v