N-tert-butyl-3-(chloromethyl)-1-(oxan-2-yl)pyrazolo[3,4-b]pyridin-6-amine | 1173989-79-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: N-tert-butyl-3-(chloromethyl)-1-(oxan-2-yl)pyrazolo[3,4-b]pyridin-6-amine
• CAS: 1173989-79-1
• 化学式: C₁₆H₂₃ClN₄O
• 分子量: 322.838
• InChiKey: PLUQYBLSFGJENT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  52
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-氯-5-(2-氯-5-羟基苯氧基)苯甲腈 、 N-tert-butyl-3-(chloromethyl)-1-(oxan-2-yl)pyrazolo[3,4-b]pyridin-6-amine 在 potassium carbonate 、 potassium iodide 作用下， 以 乙腈 、 2-甲基四氢呋喃 为溶剂， 生成 3-[5-[[6-(Tert-butylamino)-1-(oxan-2-yl)pyrazolo[3,4-b]pyridin-3-yl]methoxy]-2-chlorophenoxy]-5-chlorobenzonitrile
  参考文献：
  名称：

  Development of practical syntheses of potent non-nucleoside reverse transcriptase inhibitors

  摘要：

  The development of practical and efficient syntheses of the potent non-nucleoside reverse transcriptase inhibitors I and 2 is described. The preparation of I proceeded in four synthetic steps and in 48% overall yield from 3. The long-term synthesis of 2 proceeded in nine synthetic steps and in 47% overall yield from commercially available 2,6-diflurorpyridine. The route to 2 was highlighted by the three-step synthesis of intermediate 22 and the high yielding coupling between 18 and phenol 8. The overall sequence required no chromatography and has successfully been utilized for the manufacture of 2 on large scale. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2009.03.084
• 作为产物：
  描述：

  [6-tert-butylamino-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]methanol 在 甲基磺酰氯 、 N,N-二异丙基乙胺 作用下， 以 2-甲基四氢呋喃 为溶剂， 生成 N-tert-butyl-3-(chloromethyl)-1-(oxan-2-yl)pyrazolo[3,4-b]pyridin-6-amine
  参考文献：
  名称：

  Development of practical syntheses of potent non-nucleoside reverse transcriptase inhibitors

  摘要：

  The development of practical and efficient syntheses of the potent non-nucleoside reverse transcriptase inhibitors I and 2 is described. The preparation of I proceeded in four synthetic steps and in 48% overall yield from 3. The long-term synthesis of 2 proceeded in nine synthetic steps and in 47% overall yield from commercially available 2,6-diflurorpyridine. The route to 2 was highlighted by the three-step synthesis of intermediate 22 and the high yielding coupling between 18 and phenol 8. The overall sequence required no chromatography and has successfully been utilized for the manufacture of 2 on large scale. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2009.03.084

文献信息

• [EN] PROCESSES FOR PREPARING (AMINO-PYRAZOLOPYRIDINYL)METHOXY SUBSTITUTED BIARYL ETHERS<br/>[FR] PROCÉDÉS DE PRÉPARATION D'ÉTHERS DE BIARYLE SUBSTITUÉS PAR UN (AMINO-PYRAZOLOPYRIDINYL)MÉTHOXY
  申请人：MERCK & CO INC

  公开号：WO2009117278A2

  公开（公告）日：2009-09-24

  Processes for preparing certain (amino-pyrazolopyridinyl)methoxy-substituted biaryl ethers and their salts are described. The substituted biaryl ethers are useful as HIV non-nucleoside reverse transcriptase inhibitors. The processes include coupling a biaryl ether with a suitably protected and activated pyrazolopyridinyl methanol and then removing the protective groups from the coupled product to provide the desired substituted biaryl ether in the form of a sulfonate salt or a sulfate salt. Earlier reaction steps and the intermediates employed and obtained therein are also described. Crystalline HCl and sulfate salts of a particular (amino-pyrazolopyridmyl)-methoxy~substituted biaryl ether are described as well.
• Development of practical syntheses of potent non-nucleoside reverse transcriptase inhibitors
  作者：Jeffrey T. Kuethe、Yong-Li Zhong、Mahbub Alam、Anthony D. Alorati、Gregory L. Beutner、Dongwei Cai、Fred J. Fleitz、Andrew D. Gibb、Amude Kassim、Kathleen Linn、Danny Mancheno、Benjamin Marcune、Philip J. Pye、Jeremy P. Scott、David M. Tellers、Bangping Xiang、Nobuyoshi Yasuda、Jingjun Yin、Ian W. Davies

  DOI：10.1016/j.tet.2009.03.084

  日期：2009.6

  The development of practical and efficient syntheses of the potent non-nucleoside reverse transcriptase inhibitors I and 2 is described. The preparation of I proceeded in four synthetic steps and in 48% overall yield from 3. The long-term synthesis of 2 proceeded in nine synthetic steps and in 47% overall yield from commercially available 2,6-diflurorpyridine. The route to 2 was highlighted by the three-step synthesis of intermediate 22 and the high yielding coupling between 18 and phenol 8. The overall sequence required no chromatography and has successfully been utilized for the manufacture of 2 on large scale. (C) 2009 Published by Elsevier Ltd.