N-[4'-(benzyloxy)phenyl]-5-methoxyisatin | 324762-65-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-[4'-(benzyloxy)phenyl]-5-methoxyisatin
• 英文别名: 5-Methoxy-1-(4-phenylmethoxyphenyl)indole-2,3-dione
• CAS: 324762-65-4
• 化学式: C₂₂H₁₇NO₄
• 分子量: 359.381
• InChiKey: RWNRHMVOJDZNDV-UHFFFAOYSA-N

物化性质

• 沸点：
  571.7±60.0 °C(Predicted)
• 密度：
  1.304±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[4'-(benzyloxy)phenyl]-5-methoxyisatin 在 氢氧化钾 、 盐酸 作用下， 以 水 为溶剂， 反应 4.42h， 以75%的产率得到2-benzyloxy-7-methoxy acridine-9-carboxylic acid
  参考文献：
  名称：

  Novel applications of acridinium compounds and derivatives in homogeneous assays

  摘要：

  公开号：

  EP1403254B1
• 作为产物：
  描述：

  4-苄氧基溴苯 、 5-甲氧基靛红 在 sodium hydride 、 copper(l) iodide 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 24.33h， 以32%的产率得到N-[4'-(benzyloxy)phenyl]-5-methoxyisatin
  参考文献：
  名称：

  Novel applications of acridinium compounds and derivatives in homogeneous assays

  摘要：

  公开号：

  EP1403254B1

文献信息

• Chemiluminescent acridinum compounds and analogues thereof as substrates of hydrolytic enzymes
  申请人：Jiang Qingping

  公开号：US20050032147A1

  公开（公告）日：2005-02-10

  A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-P  Formula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P is a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following: where HE is a hydrolytic enzyme. Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.

  本文介绍了一种水解酶的化学发光底物，其具有以下一般式I，如下所示：Lumi-M-P  式I，其中“Lumi”是一种化学发光基团，能够自身（a）、与MP连接（b）或与M连接（c）产生光。Lumi的例子包括化学发光的吖啶化合物、苯并吖啶化合物、喹啉化合物、异喹啉化合物、苯并吖啶化合物、吕克吉宁化合物、螺吖啶化合物、吲哚啉化合物和异吲哚啉化合物。M是一种多价杂原子，具有至少一个孤对电子，选择氧、氮和硫之一，直接连接到Lumi的发光基团的一端，并连接到P的另一端。P是一种可以被水解酶轻易去除的基团。利用上述化合物的酶促反应如下所示：其中HE是一种水解酶。Lumi-M是一种具有与Lumi-M-P不同的物理和/或化学性质的化学发光产物。
• Chemiluminescent Acridinium Compounds and Analogues thereof as Substrates of Hydrolytic Enzymes
  申请人：Jiang Qingping

  公开号：US20060202179A1

  公开（公告）日：2006-09-14

  A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-P   Formula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P is a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following: where HE is a hydrolytic enzyme. Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.

  本文披露了一种具有以下一般式I的水解酶化学发光底物，如下所示：Lumi-M-P  式I，其中“Lumi”是一种化学发光基团，能够(a)自身产生光，(b)与MP结合产生光，以及(c)与M结合产生光。Lumi的例子包括化学发光的吖啶化合物、苯并吖啶化合物、喹啉化合物、异喹啉化合物、菲啶化合物、卢西根化合物、螺吖啶化合物、路米诺化合物和异路米诺化合物。M是一种多价杂原子，具有至少一个孤对电子，选自氧、氮和硫，在一端直接与Lumi的发光基团相连，另一端与P相连。P是一种可被水解酶轻易去除的基团。利用上述化合物的酶促反应如下：其中HE是一种水解酶。Lumi-M是一种化学发光产物，具有与Lumi-M-P不同的物理和/或化学特性。
• Novel Applications of Acridinium Compounds and Derivatives in Homogeneous Assays
  申请人：Natrajan Anand A.

  公开号：US20090029349A1

  公开（公告）日：2009-01-29

  Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus to inhibit pseudo-base formation, or acridinium sulfonamides with or without electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus.

  化学发光的吖啶化合物被用于均相分析中，以测定样品中分析物的浓度，而无需使用强酸或强碱处理。这些化学发光的吖啶化合物包括在吖啶核上具有电子供体官能团的吖啶酯，以抑制伪碱的形成，或在吖啶核上具有或不具有电子供体官能团的吖啶磺酰胺。
• CHEMILUMINESCENT SUBSTRATES OF HYDROLYTIC ENZYMES SUCH AS PHOSPHATASES
  申请人：Bayer Corporation

  公开号：EP1203091A1

  公开（公告）日：2002-05-08
• US6783948B1
  申请人：——

  公开号：US6783948B1

  公开（公告）日：2004-08-31