4-乙氧基-2,3-二氟苯胺 | 189751-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-乙氧基-2,3-二氟苯胺
• 英文名称: 4-ethoxy-2,3-difluoroaniline
• 英文别名: 2,3-difluoro-4-ethoxyaniline
• CAS: 189751-13-1
• 化学式: C₈H₉F₂NO
• mdl: MFCD09258703
• 分子量: 173.162
• InChiKey: HQGQPBARTOHEJX-UHFFFAOYSA-N

物化性质

• 沸点：
  236.0±35.0 °C(Predicted)
• 密度：
  1.231±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险等级：
  6.1
• 海关编码：
  2922299090

反应信息

• 作为反应物：
  描述：

  4-乙氧基-2,3-二氟苯胺 在 三乙烯二胺 、 N-氯代丁二酰亚胺 、 二苯醚 、 三乙酰氧基硼氢化钠 、 溶剂黄146 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 89.0h， 生成 2-ethoxy-4-fluoro-5-isopropyl-3-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile
  参考文献：
  名称：

  [EN] INDOLOQUINOLONE COMPOUNDS AS ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITORS
  [FR] COMPOSÉS D'INDOLOQUINOLONE UTILISÉS EN TANT QU'INHIBITEURS DE KINASE DU LYMPHOME ANAPLASIQUE (ALK)

  摘要：

  公开了某些吲哚喹诺酮化合物、其制备方法、药物组合物及其用途，例如用作ALK抑制剂。

  公开号：

  WO2015127629A1

文献信息

• [EN] PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OR ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME<br/>[FR] DÉRIVÉ DE BENZOTHIAZOLE CONTENANT PHÉNYLIMIDE OU SON SEL ET COMPOSITION PHARMACEUTIQUE LE COMPRENANT
  申请人：YUHAN CORP

  公开号：WO2013043001A1

  公开（公告）日：2013-03-28

  The present invention provides a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

  本发明提供了一种含有苯甲酰亚胺基的苯并噻唑衍生物或其药用可接受盐，以及其制备方法和包含其的药物组合物。所述含有苯甲酰亚胺基的苯并噻唑衍生物或其药用可接受盐可以选择性地抑制KRS和层粘连蛋白受体（LR）之间的蛋白质相互作用，从而抑制癌细胞的迁移。因此，含有苯甲酰亚胺基的苯并噻唑衍生物或其药用可接受盐可能被有益地应用于预防或治疗与癌细胞转移相关的疾病。
• PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OF ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：YUHAN CORPORATION

  公开号：US20150011528A1

  公开（公告）日：2015-01-08

  Provided is a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

  提供一种含有苯基亚胺基的苯并噻唑衍生物或其药用可接受盐，以及其制备方法和包含相同的药物组合物。该含有苯基亚胺基的苯并噻唑衍生物或其药用可接受盐可以选择性地抑制KRS和层粘连蛋白受体（LR）之间的蛋白质相互作用，从而抑制癌细胞的迁移。因此，该含有苯基亚胺基的苯并噻唑衍生物或其药用可接受盐可能被有用地应用于预防或治疗与癌细胞转移相关的疾病。
• Benzothiophenes, and their use in liquid-crystalline mixtures
  申请人：Clariant International Ltd.

  公开号：US06403172B1

  公开（公告）日：2002-06-11

  Benzothiophene derivatives of the formula (I) are used as components of liquid-crystal mixtures where the symbols and indices have the following meanings: X1 and X2, independently of one another, are —CH—, —CF—, the —(R1)C— group or the —(R1—A1—M1)C— group, with the provisos that x1) X1 and X2 are not simultaneously the —(R1)C— or —(R1—A1—M1)C— group, and x2) X1 and X2 are only simultaneously —CH— or —CF— if Z is fluorine Y1 and Y2, independently of one another, are hydrogen or fluorine, but both are not simultaneously fluorine z is hydrogen or fluorine R1 and R2, independently of one another, are, for example, a straight-chain or branched alkyl radical (with or without asymmetrical carbon atoms) having 1 to 20 carbon atoms, A1 and A2 are, for example, phenylene-1,4-diyl, M1 is undirected and is —OC(═O)—, —OC(═O)O—, —OCH2—, —(CH2)n—, —OC(═O)CH2CH2—, —OCH2CH2CH2—, —C≡C— or a single bond, m is 0 or 1, n is from 1 to 6.

  苯并噻吩衍生物的化学式（I）用作液晶混合物的组分，其中符号和指数具有以下含义：X1和X2，彼此独立，分别为—CH—、—CF—、—（R1）C—基团或—（R1—A1—M1）C—基团，但需满足以下条件：x1）X1和X2不同时为—（R1）C—或—（R1—A1—M1）C—基团；x2）仅当Z为氟时，X1和X2才能同时为—CH—或—CF—；Y1和Y2，彼此独立，分别为氢或氟，但不同时为氟；Z为氢或氟；R1和R2，彼此独立，例如为直链或支链烷基基团（带有或不带有不对称碳原子），碳原子数为1至20；A1和A2，例如为苯-1,4-二基苯基；M1为未定向的，为—OC(═O)—、—OC(═O)O—、—OCH2—、—(CH2)n—、—OC(═O)CH2CH2—、—OCH2CH2CH2—、—C≡C—或单键；m为0或1；n为1至6。
• Steroids and protein-conjugates thereof
  申请人：Regeneron Pharmaceuticals, Inc.

  公开号：US10711032B2

  公开（公告）日：2020-07-14

  Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.

  本文描述的蛋白质类固醇共轭物可用于向细胞靶向输送糖皮质激素（GCs）等。
• PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OR ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：Yuhan Corporation

  公开号：EP2758384A1

  公开（公告）日：2014-07-30