1,5-Anhydro-2,3-dideoxy-4,6-O-benzyliden-D-erythro-hexit | 26432-86-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃二恶英
• 英文名称: 1,5-Anhydro-2,3-dideoxy-4,6-O-benzyliden-D-erythro-hexit
• 英文别名: 1,5-Anhydro-4,6-O-benzyliden-2,3-didesoxy-D-glucitol；(4aR,8aS)-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxine
• CAS: 26432-86-0
• 化学式: C₁₃H₁₆O₃
• 分子量: 220.268
• InChiKey: RWAOABYFTHPWDP-LAGVYOHYSA-N

物化性质

• 沸点：
  339.4±32.0 °C(Predicted)
• 密度：
  1.125±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,5-Anhydro-2,3-dideoxy-4,6-O-benzyliden-D-erythro-hexit 在 4-二甲氨基吡啶 、 二异丁基氢化铝 、 三乙胺 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 72.0h， 生成 ((2R,3S)-3-Benzyloxy-tetrahydro-pyran-2-yl)-acetonitrile
  参考文献：
  名称：

  基于 NiII/CrII 介导的交叉偶联反应的反式稠合恶烷环系统的收敛合成

  摘要：

  基于 NiII/CrII 介导的烯基碘化物与醛的交叉偶联反应，开发了一种聚合聚醚结构的通用方法。本方法允许通过缩醛环化和还原醚化反应与恶烷环偶联。

  DOI：

  10.1055/s-2001-11398
• 作为产物：
  描述：

  O-[(4aR,8S,8aR)-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl] methylsulfanylmethanethioate 生成 1,5-Anhydro-2,3-dideoxy-4,6-O-benzyliden-D-erythro-hexit
  参考文献：
  名称：

  STILL, IAN W. J.;BANAIT, NARINDER S.;FRAZER, DONALD V., SYNTH. COMMUN., 18,(1988) N 13, C. 1461-1474

  摘要：

  DOI：

文献信息

• AMPK ACTIVATORS
  申请人：Kallyope, Inc.

  公开号：US20220002317A1

  公开（公告）日：2022-01-06

  This disclosure is directed, at least in part, to AMPK activators useful for the treatment of conditions or disorders associated with AMPK. In some embodiments, the condition or disorder is associated with the gut-brain axis. In some embodiments, condition or disorder is associated with systemic infection and inflammation from having a leaky gut barrier. In some embodiments, the AMPK activators are gut-restricted compounds. In some embodiments, the AMPK activators are agonists, super agonists, full agonists, or partial agonists.

  这份披露至少部分针对AMPK激活剂，用于治疗与AMPK相关的疾病或疾病。在某些实施例中，该疾病或疾病与肠-脑轴有关。在某些实施例中，该疾病或疾病与有漏肠屏障引起的全身感染和炎症有关。在某些实施例中，AMPK激活剂是肠道限制性化合物。在某些实施例中，AMPK激活剂是激动剂、超激动剂、全激动剂或部分激动剂。
• Correlation between Conformational Equilibria of Free Host and Guest Binding Affinity in Non-preorganized Receptors
  作者：Romen Carrillo、Ezequiel Q. Morales、Víctor S. Martín、Tomás Martín

  DOI：10.1021/jo400683j

  日期：2013.8.16

  Positive cooperativity between host conformational equilibria and guest binding has been widely reported in protein receptors. However, reported examples of this kind of cooperativity in synthetic hosts are scarce and largely serendipitous, among other things because it is hard to envision systems which display this kind of cooperativity. In order to shed some light on the correlation between conformational equilibria of free host and guest binding, selected structural modifications have been performed over a family of nonpreorganized hosts in order to induce conformational changes and to analyze their effect on the binding affinity. The conformational effect was evaluated by a theoretical conformational search and correlated with the ability of the receptors. All data suggest that those receptors that display the best association constants are able to sample folded conformations analogous to the conformational requirements for the binding of the guests. On the contrary, for those receptors where folded conformers are scarce, then the association constant and enantioselectivity clearly drop.
• STILL, IAN W. J.;BANAIT, NARINDER S.;FRAZER, DONALD V., SYNTH. COMMUN., 18,(1988) N 13, C. 1461-1474
  作者：STILL, IAN W. J.、BANAIT, NARINDER S.、FRAZER, DONALD V.

  DOI：——

  日期：——
• DISPIROPYRROLIDINE DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2684880B1

  公开（公告）日：2018-02-28
• Convergent Synthesis of <i>trans</i>-Fused Oxane Ring Systems Based on Ni^II/Cr^II-Mediated Cross-coupling Reactions
  作者：M. Teresa Díaz、Ruby L. Pérez、Elsa Rodríguez、José L. Ravelo、Julio D. Martín

  DOI：10.1055/s-2001-11398

  日期：——

  A general method for the convergent assembly of polyether structures has been developed based on a NiII/CrII-mediated cross-coupling reaction of alkenyl iodides with aldehydes. The present method allowed coupling to oxane rings via acetal cyclization and reductive etherification reactions.

  基于 NiII/CrII 介导的烯基碘化物与醛的交叉偶联反应，开发了一种聚合聚醚结构的通用方法。本方法允许通过缩醛环化和还原醚化反应与恶烷环偶联。