1,1,4,4-tetramethyl-2,3-dioxa-butane-1,4-diyl bis-hydroperoxide | 1471-09-6

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机氢过氧化物
• 英文名称: 1,1,4,4-tetramethyl-2,3-dioxa-butane-1,4-diyl bis-hydroperoxide
• 英文别名: 1,1'-dimethyl-1,1'-peroxy-diethyl bis-hydroperoxide；bis-(α-hydroperoxy-isopropyl)-peroxide；Bis-(α-hydroperoxy-isopropyl)-peroxid；Bis-(1-hydroperoxy-1-methyl-aethyl)-peroxid；2,2'-Dihydroperoxy-2,2'-diisopropylperoxid；Bis-(2-hydroperoxy-2-propyl) peroxide；2-hydroperoxy-2-(2-hydroperoxypropan-2-ylperoxy)propane
• CAS: 1471-09-6
• 化学式: C₆H₁₄O₆
• 分子量: 182.174
• InChiKey: SWOLNSKMTRLFCK-UHFFFAOYSA-N

物化性质

• 熔点：
  34-35 °C
• 沸点：
  273.9±25.0 °C(Predicted)
• 密度：
  1.229±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,1,4,4-tetramethyl-2,3-dioxa-butane-1,4-diyl bis-hydroperoxide 在 lead(IV) acetate 、 溶剂黄146 作用下， 生成 丙酮过氧化物
  参考文献：
  名称：

  Criegee; Metz, Chemische Berichte, 1956, vol. 89, p. 1714,1718

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2-过氧化二氢丙烷 生成 1,1,4,4-tetramethyl-2,3-dioxa-butane-1,4-diyl bis-hydroperoxide
  参考文献：
  名称：

  有机过氧化物研究。二十六。由丙酮和过氧化氢衍生的有机过氧化物

  摘要：

  在氢离子存在和不存在下研究了过氧化氢与丙酮的反应。在这两种情况下，最初形成的稳定过氧化物是迄今为止未知的 2,2-二氢过氧丙烷 (I)。在没有氢离子的情况下，这种过氧化物是主要产物，它会缓慢地发生自由基转变为 2,2'-二氢过氧化二丙基过氧化物 (111) 和其他高级过氧化物。在氢离子和过量过氧化丙酮的存在下，I 通过过氧化物 I11 以高产率转化为环状三聚体。

  DOI：

  10.1021/ja01533a033

文献信息

• [EN] NEW ENDOPEROXIDE COMPOUNDS, PROCESS FOR OBTAINING THEM AND USES THEREOF FOR CONTROL OF PERKINSIOSIS IN BIVALVES<br/>[FR] NOUVEAUX COMPOSÉS ENDOPEROXYDE, LEUR PROCÉDÉ D'OBTENTION ET LEURS UTILISATIONS POUR LE CONTRÔLE DE LA PERKINSIOSE CHEZ LES BIVALVES
  申请人：CCMAR CENTRO DE CIENCIAS DO MAR UNIV DO ALGARVE

  公开号：WO2020240266A1

  公开（公告）日：2020-12-03

  The present invention relates to new endoperoxide compounds and compositions, and to a process for producing them for prophylaxis and control of perkinsiosis in bivalves. Endoperoxide compounds with biological activity against Perkinsus olseni include 13 trioxolanes and 9 tetraoxanes. Protozoan parasites of the genus Perkinsus are known to infect several species of marine molluscs worldwide, like oysters, abalones, clams, scallops, pearl oysters, cockles or mussels. The present invention also describes the synthesis of these compounds, in particular of new endoperoxide compounds of the tetraoxane family. Compositions comprising endoperoxide compounds are useful for prophylaxis and control of perkinsiosis in bivalves. Therefore, the present invention also relates to a method of controlling perkinsiosis in bivalves. The present invention is in the domain of aquaculture, medicine, pharmaceuticals and biochemistry.

  本发明涉及新的内过氧化物化合物和组合物，以及用于预防和控制双壳类动物中珠虫病的生产过程。具有对奥尔森珠虫具有生物活性的内过氧化物化合物包括13个三氧杂环戊烷和9个四氧杂环戊烷。已知属于珠虫属的原生动物寄生虫会感染全球范围内的多种海洋软体动物，如牡蛎、鲍鱼、蛤、扇贝、珍珠贝、蛤蜊或贻贝。本发明还描述了这些化合物的合成，特别是四氧杂环戊烷家族的新的内过氧化物化合物。包含内过氧化物化合物的组合物对于预防和控制双壳类动物中的珠虫病是有用的。因此，本发明还涉及一种控制双壳类动物中珠虫病的方法。本发明涉及水产养殖、医学、制药和生物化学领域。
• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
  申请人：Fresenius Kabi Deutschland GmbH

  公开号：US20150297738A1

  公开（公告）日：2015-10-22

  The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M) n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

  本发明涉及一种羟烷基淀粉共轭物及其制备方法，所述羟烷基淀粉共轭物包括羟烷基淀粉衍生物和细胞毒性药剂，所述细胞毒性药剂包括至少一个次级羟基，其中羟烷基淀粉通过所述次级羟基与细胞毒性药剂连接。根据本发明的共轭物具有以下公式HAS'(-L-M)n的结构，其中M是细胞毒性药剂的残基，L是连接基团，HAS'是羟烷基淀粉衍生物的残基，n大于或等于1，且羟烷基淀粉衍生物的平均分子量（MW）高于肾脏阈值。
• Novel proton type beta zeolite, preparation method thereof and process for preparing phenol compound using the same
  申请人：UBE INDUSTRIES, LTD.

  公开号：US20040242938A1

  公开（公告）日：2004-12-02

  Disclosed are a proton type &bgr; zeolite in which an acid site showing a desorption peak with a range of ±100° C. with a center of 330° C. exists in a spectrum measured by the ammonia temperature programmed desorption method (NH 3 -TPD), and an amount of a strong acid site showing a desorption peak of 500° C. or higher is controlled to 2.5 &mgr;mol/g or less, a method for preparing the same, and a process for preparing a phenol compound by oxidizing a benzene compound with a peroxide in the presence of the proton type &bgr; zeolite.

  揭示了一种质子型β沸石，其中通过氨温度程序脱附法（NH3-TPD）测量的光谱中存在一个酸位显示出一个±100°C范围内的脱附峰，中心温度为330°C，并且控制强酸位显示出500°C或更高脱附峰的量为2.5μmol/g或更低，以及制备该沸石的方法和在质子型β沸石存在的情况下，在过氧化物存在下氧化苯化合物制备苯酚化合物的方法。
• [EN] RELEASABLE CONJUGATES<br/>[FR] CONJUGUÉS LIBÉRABLES
  申请人：QUIAPEG PHARMACEUTICALS AB

  公开号：WO2018163131A1

  公开（公告）日：2018-09-13

  The present application provides compounds of Formula (B), or pharmaceutically acceptable salts thereof, wherein D is a residue of a biologically active drug, which underdo hydrolysis under physiological conditions to release the biologically active drug and which are useful in the treatment of disorders that could be beneficially treated with the drug.

  本申请提供了化合物的公式（B），或其药用盐，其中D是生物活性药物的残留物，在生理条件下经过水解释放出生物活性药物，并且对可能受益于该药物治疗的疾病具有用处。