申请人:Mammen Mathai
公开号:US20060287369A1
公开(公告)日:2006-12-21
This invention provides compounds of formula I:
wherein R
1
, R
2
, R
3
, R
4
, R
5
, R
6
, R
7
, Ar
1
, Ar
2
, E, a, b, c and z are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β
2
adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such compounds are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
本发明提供了公式I的化合物:其中R1、R2、R3、R4、R5、R6、R7、Ar1、Ar2、E、a、b、c和z如规范中所定义,或其药学上可接受的盐、溶剂或立体异构体。本发明的化合物具有β2肾上腺素受体激动剂和毒蕈碱受体拮抗剂活性,因此,这些化合物对于治疗肺部疾病,如慢性阻塞性肺疾病和哮喘是有用的。