(R)-2-(叠氮甲基)-1-叔丁氧羰基-吡咯烷 | 259537-91-2

• 物质功能分类: 化学试剂 - 有机试剂 - 叠氮
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: (R)-2-(叠氮甲基)-1-叔丁氧羰基-吡咯烷
• 中文别名: （R）-2-（叠氮甲基）-1-Boc-吡咯烷
• 英文名称: (2R)-2-azidomethyl-N-Boc-pyrrolidine
• 英文别名: tert-Butyl (2 R)-2-(azidomethyl)-1-pyrrolidinecarboxylate；tert-butyl (2R)-2-(azidomethyl)-1-pyrrolidinecarboxylate；(R)-2-(Azidomethyl)-1-Boc-pyrrolidine；tert-butyl (2R)-2-(azidomethyl)pyrrolidine-1-carboxylate
• CAS: 259537-91-2
• 化学式: C₁₀H₁₈N₄O₂
• 分子量: 226.279
• InChiKey: HRLUZSSGBKDEGK-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  43.9
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• WGK Germany：
  3
• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  (R)-2-(叠氮甲基)-1-叔丁氧羰基-吡咯烷 生成 (R)-2-(氨甲基)-1-BOC-吡咯烷
  参考文献：
  名称：

  [EN] INHIBITORS OF THE BINDING OF CHEMOKINES I-TAC OR SDF-1 TO THE CCXCKR2 RECEPTOR
  [FR] INHIBITEURS DE CCXCKR2 D'EXPRESSION TUMORALE HUMAINE

  摘要：

  公开号：

  WO2004058705A3
• 作为产物：
  描述：

  (R)-2-(甲苯磺酰氧基甲基)吡咯烷-1-甲酸叔丁酯 以 二甲基亚砜 为溶剂， 生成 (R)-2-(叠氮甲基)-1-叔丁氧羰基-吡咯烷
  参考文献：
  名称：

  Antithrombotic agents

  摘要：

  公开号：

  EP0997474B1

文献信息

• Iridium-Catalyzed Intermolecular Azide-Alkyne Cycloaddition of Internal Thioalkynes under Mild Conditions
  作者：Shengtao Ding、Guochen Jia、Jianwei Sun

  DOI：10.1002/anie.201309855

  日期：2014.2.10

  An iridium‐catalyzed azide–alkyne cycloaddition reaction (IrAAC) of electron‐rich internal alkynes is described. It is the first efficient intermolecular AAC of internal thioalkynes. The reaction exhibits remarkable features, such as high efficiency and regioselectivity, mild reaction conditions, easy operation, and excellent compatibility with air and a broad spectrum of organic and aqueous solvents

  描述了富电子内部炔烃的铱催化的叠氮化物-炔烃环加成反应（IrAAC）。它是内部硫代炔烃的第一种有效的分子间AAC。该反应显示出显着的特征，例如高效和区域选择性，温和的反应条件，易于操作以及与空气和广泛的有机和水性溶剂的优异相容性。它是对著名的CuAAC和RuAAC点击反应的补充。
• INHIBITORS OF HUMAN TUMOR-EXPRESSED CCXCKR2
  申请人：Melikian Anita

  公开号：US20100144720A1

  公开（公告）日：2010-06-10

  Pharmaceutical compositions containing organic compounds or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed.

  本发明涉及含有有机化合物或其盐的制药组合物，其作为SDF-1或I-TAC趋化因子的调节剂。这些化合物和组合物在癌症治疗中特别是在抑制癌症增殖、生长和转移方面具有用途。本发明还揭示了干扰SDF-1和/或I-TAC与CCXCKR2受体结合以及使用本发明的化合物和制药组合物治疗癌症的方法。
• NEW INHIBITORS OF CYCLOPHILINS AND USES THEREOF
  申请人：Guichou Jean-Francois

  公开号：US20130018044A1

  公开（公告）日：2013-01-17

  The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2; A is in particular CH or N; X is in particular CO, SO 2 , CS, and R 1 is in particular H, R 2 is a group of formula NR 3 R 4 or OR 5 , R 3 and R 4 being in particular H, and R 5 an alkyl group, R 6 is in particular H or an alkyl group, and R 7 is in particular an aryl group, for its use in the prevention and/or the treatment of viral pathologies or infections.

  本发明涉及式(I)的化合物：其中：n为0、1或2；A特别为CH或N；X特别为CO、SO2、CS，R1特别为H，R2为式NR3R4或OR5的基团，其中，R3和R4特别为H，R5为烷基，R6特别为H或烷基，R7特别为芳基，用于预防和/或治疗病毒病理或感染。
• New Inhibitors of Cyclophilins and Uses Thereof
  申请人：Institut National de la Sante et de la Recherche Medicale (INSERM)

  公开号：US20140179687A1

  公开（公告）日：2014-06-26

  The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2; A is in particular CH or N; X is in particular CO, SO 2 , CS, and R 1 is in particular H, R 2 is a group of formula NR 3 R 4 or OR 5 , R 3 and R 4 being in particular H, and R 5 an alkyl group, R 6 is in particular H or an alkyl group, and R 7 is in particular an aryl group, for its use in the prevention and/or the treatment of viral pathologies or infections.

  本发明涉及一种式子为(I)的化合物：其中：n为0、1或2；A特指CH或N；X特指CO、SO2、CS，R1特指H，R2为式子NR3R4或OR5，其中，R3和R4特指H，R5为烷基；R6特指H或烷基；R7特指芳基，用于预防和/或治疗病毒病理或感染。
• SYNTHESIS AND HYBRIDIZATION OF NOVEL CHIRAL PYRROLIDINE BASED PNA ANALOGUE
  作者：Andis Slaitas、Esther Yeheskiely

  DOI：10.1081/ncn-100002559

  日期：2001.3.31

  Four different PNA fragments containing units of either the R- or S-isomer of N-(2-pyrrolidine-methyl)-N-(thymine-1-acetyl)-glycine (Pmg) were synthesized on a solid support. UV thermal melting experiments with complementary RNAs were performed and it was found that R-Pmg containing PNAs bind better to RNA than those containing the S-Pmg units.