5-Aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid | 1253518-33-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-Aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid
• 英文别名: 5-(Aminomethyl)-4-(4-methoxyphenyl)-6-methylpyridine-2-carboxylic acid
• CAS: 1253518-33-0
• 化学式: C₁₅H₁₆N₂O₃
• 分子量: 272.304
• InChiKey: YEWSTLKYSGNDTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  85.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-Aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 水 、 三乙胺 、 三氟乙酸 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 17.0h， 生成 (5-(Aminomethyl)-4-(4-methoxyphenyl)-6-methylpyridin-2-yl)(4-aminopiperidin-1-yl)methanone
  参考文献：
  名称：

  Design, Synthesis, and in Vitro Evaluation of Novel Aminomethyl-pyridines as DPP-4 Inhibitors

  摘要：

  A collection of novel aminomethyl-pyridines was designed, synthesized, and investigated as potential inhibitors of DPP-4. Optimization of the screening hit afforded a number of 5-aminomethyl-pyridines with inhibitory activity in the nanomolar range. Selected DPP-4 inhibitors were further evaluated for their selectivity over the closely related peptidase DPP-8. 5-Aminomethyl-4-(2,4-dichlorophenyl)-6-methyl-pyridine-2-carboxylic acid cyanomethyl-amide showed high potency and excellent DPP-4 selectivity [IC50: 10 (DPP-4) and 6600 nM (DPP-8)] and no toxicity in mammalian cell culture.

  DOI：

  10.1021/ml100200c
• 作为产物：
  描述：

  5-cyano-4-(4-methoxyphenyl)-6-methylpyridine-2-carboxylic acid 在 10% palladium on activated carbon 、 氢气 、 溶剂黄146 作用下， 反应 24.0h， 生成 5-Aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid
  参考文献：
  名称：

  Design, Synthesis, and in Vitro Evaluation of Novel Aminomethyl-pyridines as DPP-4 Inhibitors

  摘要：

  A collection of novel aminomethyl-pyridines was designed, synthesized, and investigated as potential inhibitors of DPP-4. Optimization of the screening hit afforded a number of 5-aminomethyl-pyridines with inhibitory activity in the nanomolar range. Selected DPP-4 inhibitors were further evaluated for their selectivity over the closely related peptidase DPP-8. 5-Aminomethyl-4-(2,4-dichlorophenyl)-6-methyl-pyridine-2-carboxylic acid cyanomethyl-amide showed high potency and excellent DPP-4 selectivity [IC50: 10 (DPP-4) and 6600 nM (DPP-8)] and no toxicity in mammalian cell culture.

  DOI：

  10.1021/ml100200c

文献信息

• Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases
  申请人：EMC microcollections GmbH

  公开号：EP2308847B1

  公开（公告）日：2014-04-02
• Design, Synthesis, and in Vitro Evaluation of Novel Aminomethyl-pyridines as DPP-4 Inhibitors
  作者：Katarzyna Kaczanowska、Karl-Heinz Wiesmüller、Arnaud-Pierre Schaffner

  DOI：10.1021/ml100200c

  日期：2010.12.9

  A collection of novel aminomethyl-pyridines was designed, synthesized, and investigated as potential inhibitors of DPP-4. Optimization of the screening hit afforded a number of 5-aminomethyl-pyridines with inhibitory activity in the nanomolar range. Selected DPP-4 inhibitors were further evaluated for their selectivity over the closely related peptidase DPP-8. 5-Aminomethyl-4-(2,4-dichlorophenyl)-6-methyl-pyridine-2-carboxylic acid cyanomethyl-amide showed high potency and excellent DPP-4 selectivity [IC50: 10 (DPP-4) and 6600 nM (DPP-8)] and no toxicity in mammalian cell culture.