7-hydroxy-1-(4-methylbenzyl)-1H-indole | 906081-87-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 7-hydroxy-1-(4-methylbenzyl)-1H-indole
• 英文别名: 1-[(4-methylphenyl)methyl]indol-7-ol
• CAS: 906081-87-6
• 化学式: C₁₆H₁₅NO
• 分子量: 237.301
• InChiKey: MPUPQTBXZILLKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  25.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-hydroxy-1-(4-methylbenzyl)-1H-indole 、 2,3,4,6-四乙酰氧基-alpha-D-吡喃葡萄糖溴化物 在 sodium hydroxide 、 苄基三丁基氯化铵 作用下， 以 二氯甲烷 为溶剂， 生成 7-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-1-(4-methylbenzyl)-1H-indole
  参考文献：
  名称：

  1-SUBSTITUTED-7-( -D-GLYCOPYRANOSYLOXY)(AZA)INDOLE COMPOUND AND PHARMACEUTICAL CONTAINING THE SAME

  摘要：

  公开号：

  EP1849795B1
• 作为产物：
  描述：

  7-benzyloxy-1-(4-methylbenzyl)-1H-indole 在 palladium 10% on activated carbon 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 生成 7-hydroxy-1-(4-methylbenzyl)-1H-indole
  参考文献：
  名称：

  1-SUBSTITUTED-7-( -D-GLYCOPYRANOSYLOXY)(AZA)INDOLE COMPOUND AND PHARMACEUTICAL CONTAINING THE SAME

  摘要：

  公开号：

  EP1849795B1

文献信息

• 1-SUBSTITUTED-7-(B-D-GLYCOPYRANOSYLOXY)(AZA)INDOLE COMPOUND AND PHARMACEUTICAL CONTAINING THE SAME
  申请人：Fushimi Nobuhiko

  公开号：US20090054356A1

  公开（公告）日：2009-02-26

  [Objective] The present invention provides a compound having an SGLT1 and/or SGLT2 inhibitory activity which is usable as an agent for the prevention or treatment of diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, obesity or the like. [Means to Solve the Problem] It is a 1-substituted-7-(β-D-glycopyranosyloxy)(aza)-indole compound represented by the general formula (I), a prodrug thereof, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof: wherein R 1 represents a halogen atom or the like; n represents j an integer number from 0 to 3; R 2 represents a hydrogen atom or the like; X represents a carbon atom which a hydrogen atom or the like binds to, or a nitrogen atom; Q represents an alkylene group or an alkenylene group each of which may have an oxygen atom or a sulfur atom in the chain; and A represents an aryl or heteroaryl group which may have a substituent.

  【目的】本发明提供一种具有SGLT1和/或SGLT2抑制活性的化合物，可用作预防或治疗糖尿病、餐后高血糖、糖耐量受损、糖尿病并发症、肥胖症等的药物。 【解决问题的手段】化合物为1-取代-7-(β-D-葡萄糖苷基氧)(氮杂)吲哚化合物，由通式(I)表示，其前药、药学上可接受的盐、水合物或溶剂化物：其中R1表示卤素原子或类似物；n表示0至3的整数；R2表示氢原子或类似物；X表示与碳原子结合的氢原子或类似物，或氮原子；Q表示可在链中具有氧原子或硫原子的烷基或烯基；A表示可能具有取代基的芳基或杂芳基。
• 1-substituted-7-(β-D-glycopyranosyloxy)(aza)indole compound and pharmaceutical containing the same
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：US07749972B2

  公开（公告）日：2010-07-06

  The present invention provides a compound having an SGLT1 and/or SGLT2 inhibitory activity which is usable as an agent for the prevention or treatment of diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, obesity or the like. It is a 1-substituted-7-(β-D-glycopyranosyloxy)(aza)-indole compound represented by the general formula (I), a prodrug thereof, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof: wherein R1 represents a halogen atom or the like; n represents j an integer number from 0 to 3; R2 represents a hydrogen atom or the like; X represents a carbon atom which a hydrogen atom or the like binds to, or a nitrogen atom; Q represents an alkylene group or an alkenylene group each of which may have an oxygen atom or a sulfur atom in the chain; and A represents an aryl or heteroaryl group which may have a substituent.

  本发明提供了一种具有SGLT1和/或SGLT2抑制活性的化合物，可用作预防或治疗糖尿病、餐后高血糖、糖耐量受损、糖尿病并发症、肥胖症等药物。它是一种代表通式（I）的1-取代-7-（β-D-葡萄糖苷基氧）（氮）吲哚化合物，其前药，或其药学上可接受的盐，或其水合物或溶剂化物：其中R1代表卤素原子或类似物；n代表0至3的整数；R2代表氢原子或类似物；X代表与碳原子结合的氢原子或类似物，或氮原子；Q代表可以在链中具有氧原子或硫原子的烷基或烯基基团；A代表可以具有取代基的芳基或杂环基团。
• US7749972B2
  申请人：——

  公开号：US7749972B2

  公开（公告）日：2010-07-06
• 1-SUBSTITUTED-7-( -D-GLYCOPYRANOSYLOXY)(AZA)INDOLE COMPOUND AND PHARMACEUTICAL CONTAINING THE SAME
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：EP1849795B1

  公开（公告）日：2011-01-26