(3aR,5R,6R,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-isopropyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol | 72659-79-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3aR,5R,6R,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-isopropyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol
• CAS: 72659-79-1
• 化学式: C₁₅H₂₆O₆
• 分子量: 302.368
• InChiKey: SEHCAABHPRJKHM-BJIWRROBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.38
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (3aR,5R,6R,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-isopropyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol 、 (R)-(1,1′-联萘-2,2′-二氧)氯膦 在 吡啶 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成 13-[[(3aR,5R,6R,6aR)-5-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-6-propan-2-yl-5,6a-dihydro-3aH-furo[2,3-d][1,3]dioxol-6-yl]oxy]-12,14-dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene
  参考文献：
  名称：

  Sugar-monophosphite ligands applied to the asymmetric Ni-catalyzed trialkylaluminum addition to aldehydes

  摘要：

  A series of readily available sugar-based phosphite ligands were applied to the Ni-catalyzed asymmetric trialkylaluminum additions to aldehydes. The ability of the catalysts to transfer chiral information to the product could be tuned by choosing suitable ligand components (configuration at C-3 of the furanoside backbone: the steric hindrance of the substituent at C-3 and the substituents/configuration of the biaryl phosphite moieties). Good enantioselectivities (ee's up to 84%) were obtained for several aryl aldehydes using several organoaluminum sources. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.05.010