3-(苯氧基甲基)苯甲醛 | 104508-27-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 3-(苯氧基甲基)苯甲醛
• 英文名称: 3-(phenoxymethyl)benzaldehyde
• CAS: 104508-27-2
• 化学式: C₁₄H₁₂O₂
• mdl: MFCD09025913
• 分子量: 212.248
• InChiKey: KZUJGQAFTCDBKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2912499000

反应信息

• 作为反应物：
  描述：

  正戊基溴化镁 、 3-(苯氧基甲基)苯甲醛 以 乙醚 为溶剂， 以47.5%的产率得到1-[3-(苯氧基甲基)苯基]-1-己醇
  参考文献：
  名称：

  取代的芳基甲基苯基醚。1.一系列新的5-脂氧合酶抑制剂和白三烯拮抗剂。

  摘要：

  已经制备了一系列新的取代的芳基甲基苯基醚。这些化合物已被测试为大鼠中性粒细胞中的5-脂氧合酶（5-LO）抑制剂，白三烯诱导的豚鼠肺实质条带收缩的体外拮抗剂以及过敏反应的慢反应物质抑制剂（SRS-A） GP体内介导的支气管痉挛。这类潜在的抗过敏/抗炎剂的大多数代表在大鼠PMN中显示出对5-LO活性的有效抑制作用。最有效的化合物2-[[[3-（1-（羟基己基）苯氧基]-甲基]喹啉（33）在大鼠PMN 5-LO分析中的I50为0.12 microM，在白三烯-中的I50为3.6 microM。诱导GP肺实质条带收缩，并且在10 mg / kg的体内GP中还表现出91％的SRS-A介导的支气管痉挛抑制，十二指肠内给药。该系列中的某些化合物在体外也是白三烯拮抗剂，其中一些在GP中显示出针对SRS-A介导的支气管痉挛的体内活性。

  DOI：

  10.1021/jm00384a017
• 作为产物：
  描述：

  3-氰基苄基溴 在 sodium hydride 、 二异丁基氢化铝 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 4.0h， 生成 3-(苯氧基甲基)苯甲醛
  参考文献：
  名称：

  取代的芳基甲基苯基醚。1.一系列新的5-脂氧合酶抑制剂和白三烯拮抗剂。

  摘要：

  已经制备了一系列新的取代的芳基甲基苯基醚。这些化合物已被测试为大鼠中性粒细胞中的5-脂氧合酶（5-LO）抑制剂，白三烯诱导的豚鼠肺实质条带收缩的体外拮抗剂以及过敏反应的慢反应物质抑制剂（SRS-A） GP体内介导的支气管痉挛。这类潜在的抗过敏/抗炎剂的大多数代表在大鼠PMN中显示出对5-LO活性的有效抑制作用。最有效的化合物2-[[[3-（1-（羟基己基）苯氧基]-甲基]喹啉（33）在大鼠PMN 5-LO分析中的I50为0.12 microM，在白三烯-中的I50为3.6 microM。诱导GP肺实质条带收缩，并且在10 mg / kg的体内GP中还表现出91％的SRS-A介导的支气管痉挛抑制，十二指肠内给药。该系列中的某些化合物在体外也是白三烯拮抗剂，其中一些在GP中显示出针对SRS-A介导的支气管痉挛的体内活性。

  DOI：

  10.1021/jm00384a017

文献信息

• PHTHALOCYANINE CRYSTAL, ELECTROPHOTOGRAPHIC PHOTORECEPTOR UTILIZING THE SAME, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE AND IMAGE FORMING APPARATUS
  申请人：Mitsubishi Chemical Corporation

  公开号：EP1997857A1

  公开（公告）日：2008-12-03

  Provided is an excellent phthalocyanine crystal having high sensitivity and little fluctuation in sensitivity for a humidity change in a use environment and applicable to the martial for solar battery, electronic paper, electrophotographic photoreceptor, etc. Namely, phthalocyanine crystal obtained by bringing a phthalocyanine crystal precursor into contact with an aromatic aldehyde compound to convert the crystal form. Also, provided is an electrophotographic photoreceptor that not only exhibits high sensitivity but also has little fluctuation in sensitivity for a humidity change in a use environment. Further, provided is an electrophotographic photoreceptor cartridge and an image-forming device, both of which can produce a stable quality images for a humidity change in a use environment by using the electrophotographic photoreceptor.

  本发明提供了一种优异的酞菁晶体，其灵敏度高，对使用环境中的湿度变化灵敏度波动小，适用于太阳能电池、电子纸、电子照相感光元件等武材。酞菁晶体是通过将酞菁晶体前体与芳香醛化合物接触转换晶体形式而获得的。此外，还提供了一种电致发光感光元件，它不仅具有高灵敏度，而且在使用环境湿度变化时灵敏度波动很小。此外，还提供了一种电致发光感光器盒和一种图像形成装置，这两种装置均可通过使用该电致发光感光器在使用环境湿度变化时生成质量稳定的图像。
• Phthalocyanine crystal, and electrophotographic photoreceptor, electrophotographic photoreceptor cartridge and image-forming device using the same
  申请人：Mitsubishi Chemical Corporation

  公开号：US10095135B2

  公开（公告）日：2018-10-09

  Provided is an excellent phthalocyanine crystal having high sensitivity and little fluctuation in sensitivity for a humidity change in a use environment and applicable to the martial for solar battery, electronic paper, electrophotographic photoreceptor, etc. Namely, phthalocyanine crystal obtained by bringing a phthalocyanine crystal precursor into contact with an aromatic aldehyde compound to convert the crystal form. Also, provided is an electrophotographic photoreceptor that not only exhibits high sensitivity but also has little fluctuation in sensitivity for a humidity change in a use environment. Further, provided is an electrophotographic photoreceptor cartridge and an image-forming device, both of which can produce a stable quality images for a humidity change in a use environment by using the electrophotographic photoreceptor.

  本发明提供了一种优异的酞菁晶体，其灵敏度高，对使用环境中的湿度变化灵敏度波动小，适用于太阳能电池、电子纸、电子照相感光元件等武材。酞菁晶体是通过将酞菁晶体前体与芳香醛化合物接触转换晶体形式而获得的。此外，还提供了一种电致发光感光元件，它不仅具有高灵敏度，而且在使用环境湿度变化时灵敏度波动很小。此外，还提供了一种电致发光感光器盒和一种图像形成装置，这两种装置均可通过使用该电致发光感光器在使用环境湿度变化时生成质量稳定的图像。
• PHTHALOCYANINE CRYSTAL, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE AND IMAGE-FORMING DEVICE USING THE SAME
  申请人：Wada Mitsuo

  公开号：US20100232830A1

  公开（公告）日：2010-09-16

  Provided is an excellent phthalocyanine crystal having high sensitivity and little fluctuation in sensitivity for a humidity change in a use environment and applicable to the martial for solar battery, electronic paper, electrophotographic photoreceptor, etc. Namely, phthalocyanine crystal obtained by bringing a phthalocyanine crystal precursor into contact with an aromatic aldehyde compound to convert the crystal form. Also, provided is an electrophotographic photoreceptor that not only exhibits high sensitivity but also has little fluctuation in sensitivity for a humidity change in a use environment. Further, provided is an electrophotographic photoreceptor cartridge and an image-forming device, both of which can produce a stable quality images for a humidity change in a use environment by using the electrophotographic photoreceptor.
• PHTHALOCYANINE CRYSTAL, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE AND IMAGE-FORMING DEVICE USING THE SAME
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20160109816A1

  公开（公告）日：2016-04-21

  Provided is an excellent phthalocyanine crystal having high sensitivity and little fluctuation in sensitivity for a humidity change in a use environment and applicable to the martial for solar battery, electronic paper, electrophotographic photoreceptor, etc. Namely, phthalocyanine crystal obtained by bringing a phthalocyanine crystal precursor into contact with an aromatic aldehyde compound to convert the crystal form. Also, provided is an electrophotographic photoreceptor that not only exhibits high sensitivity but also has little fluctuation in sensitivity for a humidity change in a use environment. Further, provided is an electrophotographic photoreceptor cartridge and an image-forming device, both of which can produce a stable quality images for a humidity change in a use environment by using the electrophotographic photoreceptor.
• US8846282B2
  申请人：——

  公开号：US8846282B2

  公开（公告）日：2014-09-30