4-氨基-2-环己基苯酚 | 92903-03-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氨基-2-环己基苯酚
• 英文名称: 4-Amino-2-cyclohexyl-phenol
• 英文别名: 4-Amino-2-cyclohexylphenol
• CAS: 92903-03-2
• 化学式: C₁₂H₁₇NO
• mdl: MFCD00019338
• 分子量: 191.273
• InChiKey: QDUSBPJVNWUNJH-UHFFFAOYSA-N

物化性质

• 沸点：
  307.1±35.0 °C(Predicted)
• 密度：
  1.116±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2922299090

SDS

4-氨基-2-环己基苯酚MSDS英文版

反应信息

• 作为反应物：
  描述：

  4-氨基-2-环己基苯酚 以 四氢呋喃 、 甲醇 、 乙醇 为溶剂， 反应 48.5h， 生成 N-[3-cyclohexyl-5-(diethylaminomethyl)-4-hydroxyphenyl]acetamide
  参考文献：
  名称：

  Antimalarial drugs. 61. Synthesis and antimalarial effects of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-alkylphenols and their N.omega.-oxides

  摘要：

  A series of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-alkylphenols and their N omega-oxides were synthesized by the condensation of 4,7-dichloroquinoline and 4,7-dichloroquinoline N omega-oxide with appropriately substituted 4-amino-2-[(diethylamino)methyl]-6-alkylphenol dihydrochlorides. The latter precursors were prepared in a six-step synthesis starting from available 2-alkylphenols. Several of the title compounds display potent antimalarial activity in mice.

  DOI：

  10.1021/jm00388a027
• 作为产物：
  描述：

  环己酚 在 镍 盐酸 、 氢气 、 sodium nitrite 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 10.5h， 生成 4-氨基-2-环己基苯酚
  参考文献：
  名称：

  Antimalarial drugs. 61. Synthesis and antimalarial effects of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-alkylphenols and their N.omega.-oxides

  摘要：

  A series of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-alkylphenols and their N omega-oxides were synthesized by the condensation of 4,7-dichloroquinoline and 4,7-dichloroquinoline N omega-oxide with appropriately substituted 4-amino-2-[(diethylamino)methyl]-6-alkylphenol dihydrochlorides. The latter precursors were prepared in a six-step synthesis starting from available 2-alkylphenols. Several of the title compounds display potent antimalarial activity in mice.

  DOI：

  10.1021/jm00388a027

文献信息

• Aryl aniline beta2 adrenergic receptor agonists
  申请人：——

  公开号：US20030229058A1

  公开（公告）日：2003-12-11

  The invention provides novel &bgr; 2 adrenergic receptor agonist compounds of formula (I): 1 wherein R 1 -R 13 and w have any of the values described in the specification. The invention also provides combinations of such compounds and other therapeutic agents, pharmaceutical compositions comprising such compounds and combinations, methods of using such compounds to treat diseases associated with &bgr; 2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

  这项发明提供了式（I）的新型β2肾上腺素受体激动剂化合物： 其中R1-R13和w具有规范中描述的任何值。该发明还提供了这些化合物与其他治疗剂的组合，包含这些化合物和组合物的药物组合物，使用这些化合物治疗与β2肾上腺素受体活性相关的疾病的方法，以及用于制备这些化合物的有用的过程和中间体。
• [EN] ARYL ANILINE BETA-2 ADRENERGIC RECEPTOR AGONISTS<br/>[FR] AGONISTES ARYLANILINE DES RECEPTEURS ADRENERGIQUES DOLLAR G(B)2
  申请人：THERAVANCE INC

  公开号：WO2003042164A1

  公开（公告）日：2003-05-22

  The invention provides novel β2 adrenergic receptor agonist compounds of formula (I): wherein R1-R13 and w have any of the values described in the specification. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β¿2? adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

  本发明提供了一种新的β2肾上腺素受体激动剂化合物，其化学式为(I)：其中R1-R13和w具有规范中描述的任何值。本发明还提供了包含这种化合物的药物组合物，使用这种化合物治疗与β2肾上腺素受体活性相关的疾病的方法，以及用于制备这种化合物的过程和中间体。
• HYBRID EPOXY RESINS
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：US20140114047A1

  公开（公告）日：2014-04-24

  A hybrid polyfunctional aliphatic and/or cycloaliphatic epoxy (H-PACE) resin composition comprising, consisting of or consisting essentially of: (a) a moiety selected from the group consisting of an aliphatic moiety, a cycloaliphatic moiety, and combinations thereof provided by the polyfunctional aliphatic and/or cycloaliphatic epoxy (PACE) resin; and (b) a moiety selected from the group consisting of an aliphatic moiety, a cycloaliphatic moiety, and combinations thereof, wherein said moiety is not provided by the PACE resin, is disclosed. Processes for making and using such resin composition are also disclosed.

  本发明涉及一种混合多功能脂肪族和/或环脂族环氧（H-PACE）树脂组合物，包括、由以下成分组成或实质上由以下成分组成：（a）由多功能脂肪族和/或环脂族环氧（PACE）树脂提供的脂肪族、环脂族或两者的一部分；以及（b）由不由PACE树脂提供的脂肪族、环脂族或两者的一部分。本发明还公开了制备和使用这种树脂组合物的方法。
• Polymer modified adducts of epoxy resins and active hydrogen containing compounds containing mesogenic moieties
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0469492A2

  公开（公告）日：1992-02-05

  Polymer modified adducts are prepared by (A) reacting (1) an epoxy resin having an average of more than one vicinal epoxide group with (2) a compound containing an average of two or more hydrogen atoms reactive with an epoxide group; and (B) partially vinylizing reacting the product from step (A); and (C) polymerizing the partially vinylized product from step (B) with (3) a polymerizable ethylenically unsaturated monomer; with the proviso that at least one of the components (1), (2) or (3) contain one or more mesogenic or rodlike moieties. These adducts are useful as epoxy resin curing agents.

  聚合物改性加合物的制备方法是：(A)将(1)具有平均一个以上副环氧基团的环氧树脂与(2)含有平均两个或两个以上与环氧基团反应的氢原子的化合物反应；以及(B)将步骤(A)的产物部分乙烯基化；(C) 将步骤(B)的部分乙烯基化产物与(3)可聚合的乙烯基不饱和单体聚合；但条件是组分(1)、(2)或(3)中至少有一种含有一个或多个介原或棒状分子。这些加合物可用作环氧树脂固化剂。
• Adducts of epoxy resins and active hydrogen containing compounds containing mesogenic moieties
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0478918A2

  公开（公告）日：1992-04-08

  Adducts containing mesogenic or rodlike moieties are prepared by reacting (1) at least one compound containing an average of more than one vicinal epoxide group per molecule with (2) at least one compound containing an average of more than one reactive hydrogen atom per molecule; with the proviso that at least one member of components (1) and (2) contains a mesogenic or rodlike moiety. These compounds are useful as curing agents for epoxy resins.

  含有中间体或棒状分子的加合物是通过以下反应制备的：(1) 至少一种平均每分子含有一个以上邻位环氧基团的化合物与 (2) 至少一种平均每分子含有一个以上活性氢原子的化合物；但(1)和(2)组分中至少有一个成员含有中间体或棒状分子。这些化合物可用作环氧树脂的固化剂。