2-(2-amino-6-methoxyphenyl)ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(2-amino-6-methoxyphenyl)ethanol
• 英文别名: Benzeneethanol, 2-amino-6-methoxy-
• 化学式: C₉H₁₃NO₂
• 分子量: 167.208
• InChiKey: QWYTZQOTARHMQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-amino-6-methoxyphenyl)ethanol 在 potassium tert-butylate 、 calcium chloride 作用下， 以 邻二甲苯 为溶剂， 140.0 ℃ 、101.33 kPa 条件下， 反应 12.0h， 以94%的产率得到4-甲氧基吲哚
  参考文献：
  名称：

  A highly active and recyclable catalyst for the synthesis of indole and phenyl ether

  摘要：

  一个新的简单催化系统由铜铝和水滑石（CuAl–HT）组成，采用简便的一锅法开发，对环境无害。

  DOI：

  10.1039/c5ra16134g
• 作为产物：
  描述：

  N-(2-(2-hydroxyethyl)-3-methoxyphenyl)pivalamide 在 氢溴酸 作用下， 以 水 为溶剂， 生成 2-(2-amino-6-methoxyphenyl)ethanol
  参考文献：
  名称：

  通过协同去稳定化进行支链选择性烯烃氢芳基化：铱催化乙酰苯胺的邻位烷基化

  摘要：

  用宽咬角和缺电子双膦 d F ppb（1,4-双（二（五氟苯基）膦基）丁烷）改性的铱（I）催化剂体系可促进不同乙酰苯胺和乙酰苯胺之间的高度支链选择性加氢芳基化反应芳基或烷基取代的烯烃。这提供了对具有合成挑战性的苯胺的直接和邻位选择性获取，并解决了与相关弗里德尔-克来福特烷基化相关的长期存在的问题。

  DOI：

  10.1002/anie.201506581

文献信息

• Oxidation dyeing process using a composition comprising a monoaminobenzene and a metal catalyst
  申请人：L'OREAL

  公开号：US10251827B2

  公开（公告）日：2019-04-09

  The invention relates to a process for dyeing keratin fibers, comprising the use of one or more metal catalysts and of a composition (A) comprising: —one or more oxidizing agents, and —at least one monoaminobenzene of formula (I), or an addition salt or solvate thereof in which the radicals R1 to R5 represent, independently of each other: a hydrogen atom; a halogen atom, a C1-C6 alkyl radical, a C1-C6 alkoxy radical, a carboxylic radical (—COOH), a sulfonic radical (—S03 H); two of the adjacent radicals R1 to R5 possibly forming, with the carbon atoms that bear them, a saturated or unsaturated 5- to 7-membered ring, optionally comprising from 1 to 2 heteroatoms, preferably oxygen, the said ring being optionally fused with a saturated or unsaturated 5- to 6-membered ring; on condition that at least one of the radicals R1 to R5 represents an optionally substituted alkoxy radical and preferably at least one of the other radicals R1 to R5 is a hydrogen atom.

  本发明涉及一种角蛋白纤维染色工艺，包括使用一种或多种金属催化剂和一种组合物（A），组合物（A）包括： -一种或多种氧化剂，和 -至少一种式（I）的单胺苯，或其加成盐或溶液，其中自由基 R1 至 R5 各自代表：氢原子、卤素原子、C1-C6 烷基、C1-C6 烷氧基、羧基 (-COOH)、磺酸基 (-S03 H)；R1 至 R5 中相邻的两个基团可与含有它们的碳原子形成饱和或不饱和的 5 至 7 元环，可选择包含 1 至 2 个杂原子，最好是氧，所述环可选择与饱和或不饱和的 5 至 6 元环融合；条件是 R1 至 R5 自由基中至少有一个代表任选取代的烷氧基，且 R1 至 R5 自由基中至少有一个是氢原子。
• Process for producing indoles
  申请人：RESEARCH ASSOCIATION FOR UTILIZATION OF LIGHT OIL

  公开号：EP0182256B1

  公开（公告）日：1992-10-07
• OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING A MONOAMINOBENZENE AND A METAL CATALYST
  申请人：L'OREAL

  公开号：US20160128922A1

  公开（公告）日：2016-05-12

  The invention relates to a process for dyeing keratin fibres, comprising the use of one or more metal catalysts and of a composition (A) comprising: —one or more oxidizing agents, and —at least one monoaminobenzene of formula (I), or an addition salt or solvate thereof in which the radicals R1 to R5 represent, independently of each other: a hydrogen atom; a halogen atom, a C1-C6 alkyl radical, a C1-C6 alkoxy radical, a carboxylic radical (—COOH), a sulfonic radical (—SO3 H); two of the adjacent radicals R1 to R5 possibly forming, with the carbon atoms that bear them, a saturated or unsaturated 5- to 7-membered ring, optionally comprising from 1 to 2 heteroatoms, preferably oxygen, the said ring being optionally fused with a saturated or unsaturated 5- to 6-membered ring; on condition that at least one of the radicals R1 to R5 represents an optionally substituted alkoxy radical and preferably at least one of the other radicals R1 to R5 is a hydrogen atom.
• US4757152A
  申请人：——

  公开号：US4757152A

  公开（公告）日：1988-07-12
• [EN] OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING A MONOAMINOBENZENE AND A METAL CATALYST<br/>[FR] PROCÉDÉ DE COLORATION PAR OXYDATION À L'AIDE D'UNE COMPOSITION COMPRENANT UN MONOAMINOBENZÈNE ET UN CATALYSEUR MÉTALLIQUE
  申请人：OREAL

  公开号：WO2014202787A1

  公开（公告）日：2014-12-24

  The invention relates to a process for dyeing keratin fibres, comprising the use of one or more metal catalysts and o f a composition (A) comprising : - one or more oxidizing agents, and - at least one monoaminobenzene of formula (I), or an addition salt or solvate thereof in which the radicals R1 to R5 represent, independently of each other: a hydrogen atom; a halogen atom, a C1-C6 alkyl radical, a C1-C6 alkoxy radical, a carboxylic radical (-COOH), a sulfonic radical (-S03 H); two of the adjacent radicals R1 to R5 possibly forming, with the carbon atoms that bear them, a saturated or unsaturated 5- to 7-membered ring, optionally comprising from 1 to 2 heteroatoms, preferably oxygen, the said ring being optionally fused with a saturated or unsaturated 5- to 6- membered ring; on condition that at least one of the radicals R1 to R5 represents an optionally substituted alkoxy radical and preferably at least one of the other radicals R1 to R5 is a hydrogen atom.