2-ethenyl-3-methoxynitrobenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-ethenyl-3-methoxynitrobenzene
• 英文别名: 2-Ethenyl-1-methoxy-3-nitrobenzene
• 化学式: C₉H₉NO₃
• 分子量: 179.175
• InChiKey: FADSGNHYOSOBFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-ethenyl-3-methoxynitrobenzene 在 palladium diacetate 一氧化碳 、 三苯基膦 作用下， 以 乙腈 为溶剂， 反应 20.0h， 以89%的产率得到4-甲氧基吲哚
  参考文献：
  名称：

  Palladium-Catalyzed Synthesis of Indoles by Reductive N-Heteroannulation of 2-Nitrostyrenes

  摘要：

  A palladium-phosphine catalyzed reductive N-heteroannulation of 2-nitrostyrenes, in the presence of carbon monoxide, producing indoles has been developed. Indoles were obtained, in moderate to excellent yield, from substituted 2-nitrostyrenes having either electron-withdrawing (NO2 and CO2Me) or electron-donating (Br, OH, Me, OMe, and OTf) substituents on the aromatic ring. Best results were obtained using palladium diacetate (6 mol %) together with triphenylphosphine (24 mol %) as the catalytic system, under 4 atm of carbon monoxide in acetonitrile at 70 degrees C. Other palladium(II) and palladium(0) complexes also catalyze the reaction.

  DOI：

  10.1021/jo970516+
• 作为产物：
  描述：

  2-溴-3-硝基苯甲醚 、 三丁基乙烯基锡 在 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 三苯基膦 作用下， 以 甲苯 为溶剂， 反应 23.5h， 以89%的产率得到2-ethenyl-3-methoxynitrobenzene
  参考文献：
  名称：

  Palladium-Catalyzed Synthesis of Indoles by Reductive N-Heteroannulation of 2-Nitrostyrenes

  摘要：

  A palladium-phosphine catalyzed reductive N-heteroannulation of 2-nitrostyrenes, in the presence of carbon monoxide, producing indoles has been developed. Indoles were obtained, in moderate to excellent yield, from substituted 2-nitrostyrenes having either electron-withdrawing (NO2 and CO2Me) or electron-donating (Br, OH, Me, OMe, and OTf) substituents on the aromatic ring. Best results were obtained using palladium diacetate (6 mol %) together with triphenylphosphine (24 mol %) as the catalytic system, under 4 atm of carbon monoxide in acetonitrile at 70 degrees C. Other palladium(II) and palladium(0) complexes also catalyze the reaction.

  DOI：

  10.1021/jo970516+

文献信息

• [EN] RING-FUSED THIAZOLINO 2-PYRIDONES, METHODS FOR PREPARATION THEREOF AND THEIR USE IN THE TREATMENT AND/OR PREVENTION OF TUBERCULOSIS<br/>[FR] THIAZOLINO 2-PYRIDONES À CYCLES FUSIONNÉS, LEURS PROCÉDÉS DE PRÉPARATION ET LEUR UTILISATION DANS LE TRAITEMENT ET/OU LA PRÉVENTION DE LA TUBERCULOSE
  申请人：QURETECH BIO AB

  公开号：WO2017175182A1

  公开（公告）日：2017-10-12

  The present disclosure provides a combination comprising: (i) a drug against tuberculosis, or a pharmaceutically acceptable salt thereof, and (ii) a compound of Formula (II), or a pharmaceutically acceptable combination thereof. The combination may be used in the treatment and/or prevention of tuberculosis.

  本公开提供了一种组合物，包括：（i）用于治疗结核病的药物或其药用盐，以及（ii）式（II）的化合物，或其药用可接受的组合物。该组合物可用于治疗和/或预防结核病。
• Palladium-Catalyzed Synthesis of Indoles by Reductive <i>N</i>-Heteroannulation of 2-Nitrostyrenes
  作者：Björn C. Söderberg、James A. Shriver

  DOI：10.1021/jo970516+

  日期：1997.8.1

  A palladium-phosphine catalyzed reductive N-heteroannulation of 2-nitrostyrenes, in the presence of carbon monoxide, producing indoles has been developed. Indoles were obtained, in moderate to excellent yield, from substituted 2-nitrostyrenes having either electron-withdrawing (NO2 and CO2Me) or electron-donating (Br, OH, Me, OMe, and OTf) substituents on the aromatic ring. Best results were obtained using palladium diacetate (6 mol %) together with triphenylphosphine (24 mol %) as the catalytic system, under 4 atm of carbon monoxide in acetonitrile at 70 degrees C. Other palladium(II) and palladium(0) complexes also catalyze the reaction.