7-[N-[2-(trimethylsilyl)ethoxycarbonyl]amino]heptanol | 401601-03-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 7-[N-[2-(trimethylsilyl)ethoxycarbonyl]amino]heptanol
• 英文别名: 2-(trimethylsilyl)ethyl 7-hydroxyheptylcarbamate；2-trimethylsilylethyl N-(7-hydroxyheptyl)carbamate
• CAS: 401601-03-4
• 化学式: C₁₃H₂₉NO₃Si
• 分子量: 275.464
• InChiKey: FTPCUFISCUTWFU-UHFFFAOYSA-N

物化性质

• 沸点：
  378.8±27.0 °C(Predicted)
• 密度：
  0.954±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.99
• 重原子数：
  18
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Fmoc-O-叔丁基-L-酪氨酸 、 三氟乙酸 、 丁酸 、 7-[N-[2-(trimethylsilyl)ethoxycarbonyl]amino]heptanol 、 alkaline earth salt of/the/ methylsulfuric acid 以8%的产率得到
  参考文献：
  名称：

  Uncompetitive Antagonism of AMPA Receptors:  Mechanistic Insights from Studies of Polyamine Toxin Derivatives

  摘要：

  Philanthotoxins are uncompetitive antagonists of Ca2+-permeable AMPA receptors presumed to bind to the pore-forming region, but a detailed molecular mechanism for this interaction is missing. Here a small library of novel philanthotoxins was designed and synthesized using a solid-phase strategy. The biological activities were investigated at cloned and "native" AMPA receptors using electrophysiological techniques. A distinct relationship between length of the polyamine moiety and the location of a secondary amino group was observed. Fitting the data to the Woodhull equation allowed the first experimental demonstration of the relative location and orientation of the philanthotoxin molecule in the receptor. These results were corroborated by in silico studies using a homology model of the AMPA receptor ion channel. Together these studies provide strong evidence for a molecular mechanism by which polyamine toxins antagonize the AMPA receptor ion channel and provide the basis for rational development of uncompetitive antagonists of AMPA receptors.

  DOI：

  10.1021/jm060606j
• 作为产物：
  描述：

  7-溴-1-庚醇 在 一水合肼 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 32.0h， 生成 7-[N-[2-(trimethylsilyl)ethoxycarbonyl]amino]heptanol
  参考文献：
  名称：

  [EN] NANOMATERIALS COMPRISING ESTER-LINKED ACETALS
  [FR] NANOMATÉRIAUX COMPRENANT DES ACÉTALS À LIAISON ESTER

  摘要：

  本公开说明书描述了组合物、制剂、纳米颗粒（如脂质纳米颗粒）和/或纳米材料及其使用方法。

  公开号：

  WO2022140252A1

文献信息

• Solid-Phase Synthesis of Polyamine Toxin Analogues:  Potent and Selective Antagonists of Ca²⁺-Permeable AMPA Receptors
  作者：Hasse Kromann、Sonata Krikstolaityte、Anne J. Andersen、Kim Andersen、Povl Krogsgaard-Larsen、Jerzy W. Jaroszewski、Jan Egebjerg、Kristian Strømgaard

  DOI：10.1021/jm020314s

  日期：2002.12.1

  The wasp toxin philanthotoxin-433 (PhTX-433) is a nonselective and noncompetitive antagonist of ionotropic receptors, such as ionotropic glutamate receptors and nicotinic acetylcholine receptors. Polyamine toxins are extensively used for the characterization of subtypes of ionotropic glutamate receptors, in particular Ca2+-permeable AMPA and kainate receptors. We have previously shown that an analogue of PhTX-433 with one of the amino groups replaced by a methylene group, philanthotoxin-83 (PhTX-83) is a selective and potent antagonist of AMPA receptors. We now describe the solid-phase synthesis of analogues of PhTX-83 and the electrophysiological characterization of these analogues on cloned AMPA and kainate receptors. The polyamine portion of PhTX-83 was modified systematically by chaniging the position. of the. secondary amino group along the polyamine chain. In another series of analogues, the acyl moiety of PhTX-83 was replaced by acids of different size and lipophilicity. Using electrophysiological techniques, PhTX-56 was shown to be a highly potent (K-i = 3.3 +/- 0.78 nM) and voltage-dependent antagonist of homomeric GluR1 receptors and was more than 1000-fold less potent when tested on heteromeric GluR1+GluR2, as well as homomeric GluR5(Q) receptors, thus being selective for Ca2+-permeable AMPA receptors. Variation of the acyl group of PhTX-83 had only minor effect on antagonist potency at homomeric GluR receptors but led to a significant decrease in the voltage-dependence. In conclusion, PhTX-56 is a novel, very potent, and selective antagonist of Ca2+-permeable AMPA receptors and is a promising tool for structure/function studies of the ion channel of the AMPA receptor.
• Uncompetitive Antagonism of AMPA Receptors:  Mechanistic Insights from Studies of Polyamine Toxin Derivatives
  作者：Trine F. Andersen、Denis B. Tikhonov、Ulrik Bølcho、Konstantin Bolshakov、Jared K. Nelson、Florentina Pluteanu、Ian R. Mellor、Jan Egebjerg、Kristian Strømgaard

  DOI：10.1021/jm060606j

  日期：2006.9.1

  Philanthotoxins are uncompetitive antagonists of Ca2+-permeable AMPA receptors presumed to bind to the pore-forming region, but a detailed molecular mechanism for this interaction is missing. Here a small library of novel philanthotoxins was designed and synthesized using a solid-phase strategy. The biological activities were investigated at cloned and "native" AMPA receptors using electrophysiological techniques. A distinct relationship between length of the polyamine moiety and the location of a secondary amino group was observed. Fitting the data to the Woodhull equation allowed the first experimental demonstration of the relative location and orientation of the philanthotoxin molecule in the receptor. These results were corroborated by in silico studies using a homology model of the AMPA receptor ion channel. Together these studies provide strong evidence for a molecular mechanism by which polyamine toxins antagonize the AMPA receptor ion channel and provide the basis for rational development of uncompetitive antagonists of AMPA receptors.
• [EN] NANOMATERIALS COMPRISING ESTER-LINKED ACETALS<br/>[FR] NANOMATÉRIAUX COMPRENANT DES ACÉTALS À LIAISON ESTER
  申请人：BEAM THERAPEUTICS INC

  公开号：WO2022140252A1

  公开（公告）日：2022-06-30

  The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

  本公开说明书描述了组合物、制剂、纳米颗粒（如脂质纳米颗粒）和/或纳米材料及其使用方法。