dichlorophosphoric acid biphenyl-4-yl ester | 55231-79-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dichlorophosphoric acid biphenyl-4-yl ester
• 英文别名: Dichlorophosphorsaeure-biphenyl-4-ylester；Phosphorsaeure-(biphenylyl-(4)-ester)-dichlorid；(Biphenylyl-(4))-dichlorophosphat；1-Dichlorophosphoryloxy-4-phenylbenzene
• CAS: 55231-79-3
• 化学式: C₁₂H₉Cl₂O₂P
• 分子量: 287.082
• InChiKey: DXOJYMMUNCDFHT-UHFFFAOYSA-N

物化性质

• 沸点：
  160 °C(Press: 0.5 Torr)
• 密度：
  1.372±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dichlorophosphoric acid biphenyl-4-yl ester 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Covalent Inhibition of Serine β-Lactamases by Novel Hydroxamic Acid Derivatives

  摘要：

  The effectiveness of beta-lactam antibiotics is greatly limited by the ability of bacteria to produce beta-lactamases. These enzymes catalyze the hydrolysis of beta-lactams and thus loss of their antibiotic activity. The search for inhibitors of beta-lactamases began soon after beta-lactams were introduced into medical practice and continues today. Some time ago, we introduced a new class of covalent serine beta-lactamase inhibitors, the O-aryloxycarbonyl hydroxamates, that inactivated these enzymes by a unique mechanism in which the active site became cross-linked. We describe in this paper some new variants of this class of inhibitor. First, we investigated compounds in which more polar hydroxamates were incorporated. These were generally not more active than the original compounds against representative class A and class C beta-lactamases, but one of them, 1-(benzoyl)-O-(phenoxycarbonyl)-3-hydroxyurea, was significantly more stable in solution, thus revealing a useful platform for further design. Second, we describe a series of O-(arylphosphoryl) hydroxamates that are also irreversible inactivators of class A and class C beta-lactamases, by phosphorylation of the enzyme, as revealed by mass spectra. These compounds did not, however, cross-link the enzyme active site A striking feature of their structure-activity profile was that hydroxamate remained the leaving group on enzyme phosphorylation rather than aryloxide, even though the aryloxide was intrinsically the better leaving group, as indicated by pK(a) values and demonstrated by the products of hydrolysis in free solution. Model building suggested that this phenomenon arises from the relative affinity of the enzyme active site components for the two leaving groups. The results obtained for both groups of inhibitors are important for further optimization of these inhibitors.

  DOI：

  10.1021/bi4003887
• 作为产物：
  描述：

  对羟基联苯 在 三乙胺 、 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 生成 dichlorophosphoric acid biphenyl-4-yl ester
  参考文献：
  名称：

  磷酸酯和硫代磷酸联苯类似物作为甾族硫酸酯酶的抑制剂。

  摘要：

  临床前研究

  DOI：

  10.1002/ddr.21245

文献信息

• REACTIVE FLAME RETARDANT AND FLAME-RETARDANT RESIN PROCESSED ARTICLE
  申请人：Kanno Toshiyuki

  公开号：US20090043032A1

  公开（公告）日：2009-02-12

  Disclosed is a reactive flame retardant which provides a resin with excellent flame retardance even when it is added in a small amount while being prevented from bleedout. Also disclosed is a flame-retardant resin processed article obtained by using such a reactive flame retardant. An organophosphorus compound represented by the general formula (I) below, wherein at least one or more of X 1 -X 3 represent a group containing phosphorus and having a terminal unsaturated group, is used as a reactive flame retardant which is reactive with resins. A flame-retardant resin processed article can be obtained by solidifying the resin composition containing the organophosphorus compound and then reacting it through heating or application of radiation.

  揭示了一种具有反应性的阻燃剂，即使在添加量很少的情况下也能为树脂提供出色的阻燃性能，同时防止渗出。还公开了一种使用这种反应性阻燃剂获得的阻燃树脂加工制品。一种有机磷化合物，其表示为下面的一般式（I），其中至少一个或多个X1-X3代表含磷并具有末端不饱和基团的基团，被用作与树脂发生反应的反应性阻燃剂。通过固化含有该有机磷化合物的树脂组合物，然后通过加热或辐射处理来反应，可以获得阻燃树脂加工制品。
• Para-xenyl phosphoric acid derivatives
  申请人：DOW CHEMICAL CO

  公开号：US02117291A1

  公开（公告）日：1938-05-17
• Helferich; Schmidt, Chemische Berichte, 1959, vol. 92, p. 2051,2053
  作者：Helferich、Schmidt

  DOI：——

  日期：——
• Zenftman, 1958, vol. 18, p. 361,363
  作者：Zenftman

  DOI：——

  日期：——
• VOINA E., BUL. UNIV. BRASOV, 1977, C 19, 183-188
  作者：VOINA E.

  DOI：——

  日期：——