(2E,2'E)-3,3'-(1,4-phenylene)bis(1-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one) | 1584741-48-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (2E,2'E)-3,3'-(1,4-phenylene)bis(1-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one)
• 英文别名: (2E,2′E)-3,3’-(1,4-phenylene)bis(1-(3-methoxy-4-hydroxyphenyl)prop-2-en-1-one)；(E)-1-(4-hydroxy-3-methoxyphenyl)-3-[4-[(E)-3-(4-hydroxy-3-methoxyphenyl)-3-oxoprop-1-enyl]phenyl]prop-2-en-1-one
• CAS: 1584741-48-9
• 化学式: C₂₆H₂₂O₆
• 分子量: 430.457
• InChiKey: SUIMYYLDVNIFIK-MKICQXMISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对苯二甲醛 、 香草乙酮 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以70.2%的产率得到(2E,2'E)-3,3'-(1,4-phenylene)bis(1-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one)
  参考文献：
  名称：

  一种非ATP竞争性FGFR1抑制剂及其应用

  摘要：

  本发明属于药学领域，具体涉及一种特定的非ATP竞争性FGFR1抑制剂在制备抗肿瘤药物及与肿瘤相关疾病的治疗药物中的应用，本发明涉及小分子化合物L16H50能够通过非ATP依赖的方式抑制FGFR1及其信号通路的激活，从而抑制肿瘤细胞的增殖和生存，进而发挥良好的体外及体内的抗肿瘤效果。

  公开号：

  CN106995368B

文献信息

• Symmetric Bis-chalcones as a New Type of Breast Cancer Resistance Protein Inhibitors with a Mechanism Different from That of Chromones
  作者：Evelyn Winter、Patrícia Devantier Neuenfeldt、Louise Domeneghini Chiaradia-Delatorre、Charlotte Gauthier、Rosendo Augusto Yunes、Ricardo José Nunes、Tânia Beatriz Creczynski-Pasa、Attilio Di Pietro

  DOI：10.1021/jm401879z

  日期：2014.4.10

  Potent ABCG2 inhibitors were recently identified as asymmetric chromones with different types of substituents. We here synthesized symmetric bis-chalcones that were differently substituted and screened for their ability to inhibit mitoxantrone efflux from ABCG2-transfected HEK293 cells. Potent bis-chalcone inhibitors were identified, the efficiency depending on both position of the central ketone groups and the number and positions of lateral methoxy substituents. The best derivative, namely, 1p, was selective for ABCG2 over P-glycoprotein and MRP1, appeared not to be transported by ABCG2, and was at least as active on various drug-selected cancer cells overexpressing ABCG2. Compound 1p stimulated the ABCG2 basal ATPase activity by contrast to a chromone lead that inhibited it, suggesting different mechanisms of interaction. Combination of both types of inhibitors produced synergistic effects, leading to complete inhibition at very low
• Bis-chalcone polyphenols with potential preventive and therapeutic effects on PD: Design, synthesis and in vitro disaggregation activity against α-synuclein oligomers and fibrils
  作者：Bing Jiang、Feng Han、Ming-Huan Lü、Zhen-Ping Wang、Wei Liu、Yun-Xiao Zhang、Ji Xu、Rui-Jun Li

  DOI：10.1016/j.ejmech.2022.114529

  日期：2022.9