2-methyl-2-methoxy-3,4,5-trihydrofuran | 73750-16-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methyl-2-methoxy-3,4,5-trihydrofuran
• 英文别名: 2-methoxy-2-methyl-tetrahydrofuran；2-methoxy-2-methylfuran；2-methoxy-2-methyl-tetrahydro-furan；Tetrahydrofuran, 2-methyl-2-methoxy；2-methoxy-2-methyloxolane
• CAS: 73750-16-0
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: PZGCEXNABJBCDY-UHFFFAOYSA-N

物化性质

• 沸点：
  115-117 °C
• 密度：
  0.932 g/cm3(Temp: 25 °C)
• 保留指数：
  821;753

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴甲基四氢呋喃 在 四氢糠醇 、 盐酸 、 氢氧化钾 作用下， 生成 2-methyl-2-methoxy-3,4,5-trihydrofuran
  参考文献：
  名称：

  Paul; Tchelitcheff, Bulletin de la Societe Chimique de France, 1950, p. 520,524

  摘要：

  DOI：

文献信息

• The Mechanism of Gold(I)-Catalyzed Hydroalkoxylation of Alkynes: An Extensive Experimental Study
  作者：Alexander Zhdanko、Martin E. Maier

  DOI：10.1002/chem.201303795

  日期：2014.2.10

  An extensive experimental study of the mechanism of gold(I)‐catalyzed hydroalkoxylation of internal alkynes has been conducted by using NMR spectroscopy. This study was focused on the organogold intermediates, observations of actual catalytic intermediates in situ, and the reaction kinetics that are involved in this reaction. Based on the experimental results, a complete mechanistic picture was established

  使用NMR光谱对金（I）催化的内部炔烃加氢烷氧基化机理进行了广泛的实验研究。这项研究的重点是有机金中间体，原位实际催化中间体的观察以及该反应涉及的反应动力学。根据实验结果，建立了完整的机理图，包括解释了稀有物种的作用的循环和非循环过程。我们已经表明，内部炔烃的金催化加氢烷氧基化反应只需要一个金原子就可以进行催化循环，这证明了有关协同金催化作用的最新假设。
• Mechanistic Studies in the Radical Induced DNA Strand Cleavage—Formation and Reactivity of the Radical Cation Intermediate
  作者：Ralf Glatthar、Martin Spichty、Andreas Gugger、Rohit Batra、Wolfgang Damm、Matthias Mohr、Hendrik Zipse、Bernd Giese

  DOI：10.1016/s0040-4020(00)00335-5

  日期：2000.6

  heterolytic cleavage of 4′-DNA radical 1 and the regioselective attack of nucleophiles at the intermediate DNA radical cation 3, the chemistry of model radical 8 was studied. It turned out that the heterolytic cleavage in water is favored over homolysis because of the effective solvation of the ions 9 and 10. The regioselectivity of the nucleophilic attack at radical cation 10 can be explained with the

  为了了解4'-DNA自由基1的异源裂解和亲核试剂对中间DNA自由基阳离子3的区域选择性攻击，对模型自由基8的化学性质进行了研究。事实证明，由于离子9和10的有效溶剂化，在水中的杂化裂解比均质裂解更受青睐。可以用价键构型混合（VBCM）模型解释在自由基阳离子10处亲核进攻的区域选择性。
• Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same
  申请人：Hoveyda Hamid R.

  公开号：US20110105389A1

  公开（公告）日：2011-05-05

  The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (GRLN, growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and/or variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as antagonists or inverse agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, obesity and obesity-associated disorders, appetite or eating disorders, addictive disorders, cardiovascular disorders, gastrointestinal disorders, genetic disorders, hyperproliferative disorders, central nervous system disorders and inflammatory disorders.

  本发明提供了新型构象定义的大环化合物，已被证明是生长激素分泌素受体（GRLN，生长激素分泌素受体，GHS-R1a及其亚型、异构体和/或变种）的选择性调节剂。本文还描述了合成这些新型化合物的方法。这些化合物可用作生长激素分泌素受体的拮抗剂或逆向激动剂，以及用于治疗和预防一系列医学疾病，包括但不限于代谢和/或内分泌紊乱、肥胖和与肥胖相关的疾病、食欲或进食紊乱、成瘾紊乱、心血管疾病、胃肠道疾病、遗传疾病、过度增殖性疾病、中枢神经系统疾病和炎症性疾病。
• [EN] PROCESS OF PREPARING (1R, 4R, 5S)-4-(2-CHLOROETHYL)-1-((S)-((S)-CYCLOHEX-2-EN-1-YL)(HYDROXY)METHYL)-5-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE(SALINOSPORAMIDE A; MARIZOMIB)<br/>[FR] PROCÉDÉ DE PRÉPARATION DE (1R, 4R, 5S)-4-(2-CHLOROÉTHYL)-1-((S)-((S)-CYCLOHEX-2-EN-1-YL)(HYDROXY) MÉTHYL)-5-MÉTHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE(SALINOSPORAMIDE A ; MARIZOMIB)
  申请人：CELGENE INT II SARL

  公开号：WO2021076629A1

  公开（公告）日：2021-04-22

  The present invention is directed to a process for the synthesis of (1R, 4R, 5S)-4-(2- chloroethyl)-1-((S)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-5-methyl-6-oxa-2- azabicyclo[3.2.0]heptane-3,7-dione; compound 1 (salinosporamide A, marizomib): (Compound 1).

  本发明涉及一种合成（1R，4R，5S）-4-（2-氯乙基）-1-（（S）-（（S）-环己-2-烯-1-基）（羟基）甲基）-5-甲基-6-氧代-2-氮杂双环[3.2.0]庚烷-3,7-二酮的方法；化合物1（salinosporamide A，marizomib）：（化合物1）。
• Continuous process for the preparation of random conjugated diene/vinyl arene copolymers
  申请人：Polimeri Europa S.p.A.

  公开号：EP1829906A1

  公开（公告）日：2007-09-05

  Continuous process carried out in the presence of at least two reactors in series, for the preparation of statistical vinyl arene/conjugated diene copolymers, the vinyl arene content ranging from 15 to 50% by weight, by means of the copolymerization under isothermal conditions in a hydrocarbon solvent, at a temperature ranging from 30 to 120°C, of vinyl arene/conjugated diene monomers, in the presence of at least one initiator and a 2-methoxy ethyl tetra-hydrofuran (THFA-ethyl) modifier.

  在至少两个串联反应器存在的情况下，通过乙烯基炔/共轭二烯单体在 30 至 120°C 的温度范围内，在烃溶剂中，在至少一种引发剂和 2-甲氧基乙基四氢呋喃（THFA-乙基）改性剂存在的等温条件下进行共聚，制备统计乙烯基炔/共轭二烯共聚物（乙烯基炔含量按重量计为 15%至 50%）的连续工艺。