p-tolyl 4-methoxybenzodithioate | 61885-74-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: p-tolyl 4-methoxybenzodithioate
• 英文别名: 4-Methylphenyl 4-methoxybenzenecarbodithioate；(4-methylphenyl) 4-methoxybenzenecarbodithioate
• CAS: 61885-74-3
• 化学式: C₁₅H₁₄OS₂
• 分子量: 274.408
• InChiKey: JPDLQFCVTXDGKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  66.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  p-tolyl 4-methoxybenzodithioate 在 叔丁基硫醇 、 三乙胺 、 间氯过氧苯甲酸 作用下， 以 乙醚 、 氯仿 为溶剂， 生成 1-methoxy-4-(tosylmethyl)benzene
  参考文献：
  名称：

  Veenstra,G.E.; Zwanenburg,B., Recueil des Travaux Chimiques des Pays-Bas, 1976, vol. 95, p. 195 - 201

  摘要：

  DOI：
• 作为产物：
  描述：

  4-methoxythiobenzoic acid 在 caesium carbonate 作用下， 以 间二甲苯 、 乙腈 为溶剂， 反应 0.08h， 生成 p-tolyl 4-methoxybenzodithioate
  参考文献：
  名称：

  Ynamide-Mediated Thionoester and Dithioester Syntheses

  摘要：

  A novel ynamide-mediated synthesis of thionoesters and dithioesters is described. The selective addition reactions of various monothiocarboxylic acids with ynamide furnish alpha-thioacyloxyenamides, which undergo transesterification with nucleophilic -OH or -SH species to afford thionoesters and dithioesters, respectively. The broad substrate scope, mild reaction conditions, and excellent yields make this method an attractive synthetic approach to thionoesters and dithioesters.

  DOI：

  10.1021/acs.orglett.0c02402

文献信息

• Synthesis and Functionalization of Thiophosphonium Salts: A Divergent Approach to Access Thioether, Thioester, and Dithioester Derivatives
  作者：Gurupada Hazra、Ahmad Masarwa

  DOI：10.1021/acs.orglett.3c02422

  日期：2023.9.1

  practical method for efficiently obtaining a diverse range of thiophosphonium salts. This method involves the direct coupling of commercially available thiols and aldehydes with Ph3P and TfOH. The setup is simple and carried out in a metal-free manner. The synthetic utility of these salts is demonstrated through various examples of C–P bond functionalizations, enabling the synthesis of thioether, deuterated

  在此，我们报告了一种有效获得各种硫代鏻盐的简单实用方法。该方法涉及将市售的硫醇和醛与Ph 3 P和TfOH直接偶联。设置简单并且以无金属的方式进行。这些盐的合成效用通过 C-P 键功能化的各种例子得到证明，能够合成硫醚、氘代硫醚、硫酯和二硫酯衍生物。这些产品作为有价值的构建模块，产量很高。
• Ynamide-Mediated Thionoester and Dithioester Syntheses
  作者：Chaochao Yao、Jinhua Yang、Xiaobiao Lu、Shuyu Zhang、Junfeng Zhao

  DOI：10.1021/acs.orglett.0c02402

  日期：2020.8.21

  A novel ynamide-mediated synthesis of thionoesters and dithioesters is described. The selective addition reactions of various monothiocarboxylic acids with ynamide furnish alpha-thioacyloxyenamides, which undergo transesterification with nucleophilic -OH or -SH species to afford thionoesters and dithioesters, respectively. The broad substrate scope, mild reaction conditions, and excellent yields make this method an attractive synthetic approach to thionoesters and dithioesters.
• Veenstra,G.E.; Zwanenburg,B., Recueil des Travaux Chimiques des Pays-Bas, 1976, vol. 95, p. 195 - 201
  作者：Veenstra,G.E.、Zwanenburg,B.

  DOI：——

  日期：——