2,3-dimethylpentanoylamide | 13127-01-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,3-dimethylpentanoylamide
• 英文别名: (2S,3S)-2,3-dimethylpentanamide
• CAS: 13127-01-0
• 化学式: C₇H₁₅NO
• 分子量: 129.202
• InChiKey: HRBAJVQRJUTNMM-WDSKDSINSA-N

物化性质

• 熔点：
  111-112 °C
• 沸点：
  259.4±8.0 °C(Predicted)
• 密度：
  0.887±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3-dimethylpentanoylamide 在 硫酸 、 sodium nitrite 作用下， 反应 0.5h， 生成 (2S,3S)-2,3-dimethylpentanoic acid
  参考文献：
  名称：

  Enantioselective Radical Addition/Trapping Reactions with α,β-Disubstituted Unsaturated Imides. Synthesis of anti-Propionate Aldols

  摘要：

  This manuscript describes a highly diastereo- and enantioselective intermolecular radical addition/hydrogen atom transfer to alpha,beta-disubstituted enoates. Additionally, we show that anti-propionate aldol-like products can be easily prepared from alpha-methyl-beta-acyloxyenoates in good yields and high diastereo- and enantioselectivities.

  DOI：

  10.1021/ja043371e
• 作为产物：
  描述：

  惕格酸 在 Amberlyst 15 、 草酰氯 、 cyclopropyl (1S,2R)-inda-box 、 sodium hydride 、 N,N-二甲基甲酰胺 、 magnesium iodide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 7.25h， 生成 2,3-dimethylpentanoylamide
  参考文献：
  名称：

  Enantioselective Radical Addition/Trapping Reactions with α,β-Disubstituted Unsaturated Imides. Synthesis of anti-Propionate Aldols

  摘要：

  This manuscript describes a highly diastereo- and enantioselective intermolecular radical addition/hydrogen atom transfer to alpha,beta-disubstituted enoates. Additionally, we show that anti-propionate aldol-like products can be easily prepared from alpha-methyl-beta-acyloxyenoates in good yields and high diastereo- and enantioselectivities.

  DOI：

  10.1021/ja043371e

文献信息

• Rossi,R., Gazzetta Chimica Italiana, 1967, vol. 97, p. 1239 - 1257
  作者：Rossi,R.

  DOI：——

  日期：——
• PEPTIDE MACROCYCLIZATION ENZYME
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US20210139917A1

  公开（公告）日：2021-05-13

  A peptide cyclase that has the amino acid sequence represented by SEQ ID NO: 1 or a mutated sequence thereof, or a peptide cyclase that has an amino acid sequence encoded by a base sequence encoding the amino acid sequence represented by SEQ ID NO: 1 or a mutated sequence thereof; DNA encoding the peptide cyclase; a method for producing the peptide cyclase; and a method for producing a cyclic peptide using the peptide cyclase.
• [EN] APJ RECEPTOR COMPOUNDS<br/>[FR] COMPOSÉS DE RÉCEPTEURS APJ
  申请人：ANCHOR THERAPEUTICS INC

  公开号：WO2015010045A1

  公开（公告）日：2015-01-22

  The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the G protein coupled receptor apelin, also known as the APJ receptor. The APJ receptor compounds are derived from the il intracellular loop and domain of the APJ receptor. The invention also relates to the use of these APJ receptor compounds and pharmaceutical compositions comprising the APJ receptor compounds in the treatment of diseases and conditions associated with APJ receptor modulation, such as cardiovascular diseases, (e.g., hypertension and heart failure, such as congestive heart failure), cancer, diabetes, stem cell trafficking, fluid homeostasis, cell proliferation, immune function, obesity, metastatic disease, and HIV infection.
• Enantioselective Radical Addition/Trapping Reactions with α,β-Disubstituted Unsaturated Imides. Synthesis of <i>a</i><i>nti</i>-Propionate Aldols
  作者：Mukund P. Sibi、Goran Petrovic、Jake Zimmerman

  DOI：10.1021/ja043371e

  日期：2005.3.1

  This manuscript describes a highly diastereo- and enantioselective intermolecular radical addition/hydrogen atom transfer to alpha,beta-disubstituted enoates. Additionally, we show that anti-propionate aldol-like products can be easily prepared from alpha-methyl-beta-acyloxyenoates in good yields and high diastereo- and enantioselectivities.