2-methylhept-2-en-6-ynoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methylhept-2-en-6-ynoic acid
• 化学式: C₈H₁₀O₂
• 分子量: 138.166
• InChiKey: DWGBFFSKAJCARM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  惕格酸 、 3-溴丙炔 在 正丁基锂 、 二乙胺 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 1.5h， 生成 2-methylhept-2-en-6-ynoic acid 、 2-Ethenyl-2-methylpent-4-ynoic acid
  参考文献：
  名称：

  使用异羟肟酸的烯烃加氢官能化：自由基介导的烯烃水合方法

  摘要：

  描述了自由基介导的烯烃水合方法。本策略利用了异羟肟酸的独特的自由基反应性，该异羟肟酸既可以用作合成有用的以氧为中心的自由基物种，又可以用作合适的基于氢原子的供体。该反应歧管已应用于烯烃水合和串联烯烃-烯烃碳环化过程。

  DOI：

  10.1021/ol5020202

文献信息

• Novel heterocyclic pesticidal compounds
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0294229A2

  公开（公告）日：1988-12-07

  Compounds of the formula (I) which contain between 10 and 27 carbon atoms, and wherein m and n are independently selected from 0, 1 and 2; R2a is hydrogen, methyl, or ethyl; R2b is acetylene or contains between 3 and 18 carbon atoms and is a group R7, wherein R7 is a C1-13 non-aromatic hydrocarbyl group, optionally substituted by a cyano or Ci-4 carbalkoxy group and/or by one or two hydroxy groups and/or by one to five halo atoms which are the same or different and/or by one to three groups R8 which are the same or different and each contain one to four hetero atoms, which are the same or different and are chosen from oxygen, sulphur, nitrogen and silicon, 1 to 10 carbon atoms and optionally 1 to 6 fluoro or chloro atoms or R2b is a 6-membered aromatic ring substituted by cyano and/or by one to three groups R8 and/or by a group -C≡CH, -C≡C-R7 or C≡C-halo and/or by one to five halo atoms and/or by one to three Ci-4 haloalkyl groups wherein R7 and R8 are as hereinbefore defined; R4 and R6 are the same or different and are chosen from hydrogen, methyl, trifluoromethyl or cyano; and R5 is hydrogen or methyl provided that R2b is not propyl or butyl are described which have pesticidal activity, particularly against arthropod pests. Pesticidal formulations containing the compounds of the formula (I), their use in the corttrol of pests and method for their preparation are also disclosed,

  式 (I) 的化合物 其中 m 和 n 独立地选自 0、1 和 2； R2a 是氢、甲基或乙基；R2b 是炔基或含有 3 至 18 个碳原子且是基团 R7，其中 R7 是 C1-13 非芳香族烃基，任选被氰基或 Ci-4 碳烷氧基和/或一个或两个羟基和/或一至五个相同或不同的卤原子和/或一至三个相同或不同且各含有一至四个杂原子的基团 R8 取代、或 R2b 是被氰基和/或被 1 至 3 个基团 R8 和/或被基团-C≡CH、-C≡C-R7 或 C≡C-halo 和/或被 1 至 5 个卤原子和/或被 1 至 3 个 Ci-4 卤烷基取代的 6 元芳香环，其中 R7 和 R8 如前定义；R4和R6相同或不同，选自氢、甲基、三氟甲基或氰基；R5为氢或甲基，但R2b不是丙基或丁基。还公开了含有式（I）化合物的杀虫制剂、其在防治害虫中的用途及其制备方法、
• US5502073A
  申请人：——

  公开号：US5502073A

  公开（公告）日：1996-03-26
• [EN] METHODS AND COMPOSITIONS FOR MODULATING HAIR GROWTH, WOUND HEALING AND SCAR REVISION<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR MODULER LA POUSSE DE CHEVEUX, LA CICATRISATION DE PLAIE ET LA RÉVISION DE CICATRICE
  申请人：FOLLICA INC

  公开号：WO2012065065A9

  公开（公告）日：2012-10-11

  [EN] The invention relates to methods for (i) modulating hair growth and (ii) improving wound healing, e.g., scarless wound healing, and scar revision in human subjects involving the administration of one or more compounds provided herein. Compositions and uses of compositions containing the compounds provided herein are also described. The compound, composition thereof, or treatment(s) comprising the compound may be administered alone or in combination with (e.g., concurrently with, before, and/or after) other treatments for the enhancement or inhibition of hair growth or for the improvement of wound healing or scar revision. Such combination treatments may involve mechanical or physical treatments that cause integumental perturbation (e.g., laser, dermabrasion, etc.); immune stimulation; chemical treatments; and/or surgical treatments for the enhancement or inhibition of hair growth or for the improvement of wound healing or scar revision.
  [FR] L'invention porte sur des procédés pour (i) moduler la pousse de cheveux et (ii) améliorer la cicatrisation de plaie, par exemple, la cicatrisation de plaie sans cicatrice, et la révision de cicatrice chez des sujets humains, lesquels procédés comprennent l'administration d'un ou plusieurs composés décrits présentement. L'invention porte également sur des compositions et sur des utilisations de compositions contenant les composés décrits présentement. Le composé, sa composition ou le ou les traitements comprenant le composé peuvent être administrés seuls ou en combinaison avec (par exemple, simultanément avec, avant et/ou après) d'autres traitements pour l'amélioration ou l'inhibition de la pousse de cheveux ou l'amélioration de la cicatrisation de plaie ou de la révision de cicatrice. De tels traitements combinés peuvent comprendre des traitements mécaniques ou physiques qui provoquent une perturbation tégumentaire (par exemple, laser, dermabrasion, etc.); une stimulation immunitaire; des traitements chimiques; et/ou des traitements chirurgicaux pour l'amélioration ou l'inhibition de la pousse de cheveux ou l'amélioration de la cicatrisation de plaie ou de la révision de cicatrice.
• Alkene Hydrofunctionalization Using Hydroxamic Acids: A Radical-Mediated Approach to Alkene Hydration
  作者：Benjamin C. Giglio、Erik J. Alexanian

  DOI：10.1021/ol5020202

  日期：2014.8.15

  A radical-mediated approach to alkene hydration is described. The present strategy capitalizes on the unique radical reactivity of hydroxamic acids, which are capable of functioning as both synthetically useful oxygen-centered radical species and suitable hydrogen atom-based donors. This reaction manifold has been applied to both alkene hydrations and tandem alkene–alkene carbocyclization processes

  描述了自由基介导的烯烃水合方法。本策略利用了异羟肟酸的独特的自由基反应性，该异羟肟酸既可以用作合成有用的以氧为中心的自由基物种，又可以用作合适的基于氢原子的供体。该反应歧管已应用于烯烃水合和串联烯烃-烯烃碳环化过程。