2,2'-dinitro-benzophenone | 51727-42-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-dinitro-benzophenone
• 英文别名: 2,2'-Dinitro-benzophenon；dinitrobenzophenone；Bis(2-nitrophenyl)methanone
• CAS: 51727-42-5
• 化学式: C₁₃H₈N₂O₅
• 分子量: 272.217
• InChiKey: GKQPYCWSUVGAGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2914700090

反应信息

• 作为反应物：
  描述：

  2,2'-dinitro-benzophenone 在 亚硝酸乙酯 、 硫酸 、 铁粉 、 溶剂黄146 作用下， 生成 o,o'-diiodobenzophenone
  参考文献：
  名称：

  Heyl, Journal fur praktische Chemie (Leipzig 1954), 1899, vol. <2> 59, p. 447

  摘要：

  DOI：
• 作为产物：
  描述：

  二苯基羟基乙酸 在 chromium(VI) oxide 、 硝酸 、 溶剂黄146 作用下， 生成 2,2'-dinitro-benzophenone
  参考文献：
  名称：

  339.苯甲酸和芴羧酸的硝化

  摘要：

  DOI：

  10.1039/jr9320002360

文献信息

• Iminothiadiazine Dioxide Compounds as BACE Inhibitors, Compositions and Their Use
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150307465A1

  公开（公告）日：2015-10-29

  In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 9 , ring A, ring B, m, n, p, -L 1 -, -L 2 -, and -L 3 - is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (“Aβ”) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's disease, are also disclosed.

  本发明提供了多种形式的亚氨基噻二唑二氧化物化合物，包括公式(I)的化合物： 包括它们的立体异构体，以及所述立体异构体的药用可接受盐，其中R1、R2、R3、R4、R5、R9、环A、环B、m、n、p、-L1-、-L2-和-L3-都是独立选择且按本文定义。发明的新型亚氨基噻二唑二氧化物化合物出人意料地被发现具有预期的特性，使其作为BACE抑制剂以及/或用于治疗和预防与β-淀粉样蛋白（“Aβ”）生成相关的各种病理学具有优势。还公开了包含一个或多个此类化合物（单独使用和与一个或多个其他活性成分组合使用）的药物组合物，以及它们的制备方法和用于治疗与淀粉样β（Aβ）蛋白相关的病理学，包括阿尔茨海默病的方法。
• Substituted pyridoindoles as serotonin agonists and antagonists
  申请人：——

  公开号：US20040186094A1

  公开（公告）日：2004-09-23

  The present invention is directed to certain novel compounds represented by structural Formula (I) 1 or pharmaceutically acceptable salt forms thereof, wherein R 1 , R 5 , R 6 , R 7 , R 8 , R 9 , X, b, k, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.

  本发明涉及一些新型化合物，其结构式表示为（I）或其药用盐形式，其中R1、R5、R6、R7、R8、R9、X、b、k和n以及虚线在此处描述。本发明还涉及包含这些新型化合物作为活性成分的药物配方，以及这些新型化合物及其配方在治疗某些疾病中的用途。本发明的化合物是5-羟色胺激动剂和拮抗剂，在控制或预防包括肥胖、焦虑、抑郁症、精神病、精神分裂症、睡眠障碍、性功能障碍、偏头痛、头痛相关疾病、社交恐惧症以及胃肠道疾病（如胃肠道运动功能障碍）等中枢神经系统疾病中有用。
• 1-Phenyl-5-heterocyclic-1H-1, 2,4-triazole-3-carboxamide derivates, process for preparation of the same, and fungicidal composition comprising the same
  申请人：KUREHA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0562479A1

  公开（公告）日：1993-09-29

  A derivative of 1-phenyl-5-heterocyclic-1H-1,2,4-triazole-3-carboxamide represented by the following general formula (I), a process for the manufacture thereof, and an fungicidal composition comprising the same as an active ingredient. wherein R¹ is a C₁-C₆ alkyl group, R² is a C₁-C₈ alkyl group or a phenylmethyl group, X¹ represents a hydrogen atom, a C₁-C₄ alkyl group or a halogen atom, Y¹ is a hydrogen atom or a C₁-C₄ alkyl group, Y² is a hydrogen atom, a C₁-C₄ alkyl group, or a halogen atom, A¹ represents a group -N=CH-, -NH-, -N(C₁-C₄ alkyl)-, -N(Ph)-, -O-, or -S-, and W¹ denotes a group -C(W²)= or -N=, wherein W² is a hydrogen atom, a C₁-C₄ alkyl group, or a halogen atom.

  一种由以下通用公式（I）表示的1-苯基-5-杂环-1H-1,2,4-三唑-3-羧酰胺的衍生物，其制备方法，以及包含其作为活性成分的杀真菌组合物。其中R¹是C₁-C₆烷基，R²是C₁-C₈烷基或苯甲基，X¹代表氢原子，C₁-C₄烷基或卤素原子，Y¹是氢原子或C₁-C₄烷基，Y²是氢原子，C₁-C₄烷基或卤素原子，A¹表示基团-N=CH-，-NH-，-N（C₁-C₄烷基）-，-N（Ph）-，-O-或-S-，W¹表示基团-C（W²）=或-N=，其中W²是氢原子，C₁-C₄烷基或卤素原子。
• Synthesis and Electrophilic Substitution of Pyrido[2,3,4-kl]-acridines
  作者：Avi Koller、Amira Rudi、Marta Gravalos、Yoel Kashman

  DOI：10.3390/60400300

  日期：——

  Several new pyrido[2,3,4-kl]acridines were synthesized by reacting naphthoquinone, juglone or cyclohexan-1,3-dione with β,β’-diaminoketones in a biomimetic reaction. The structure of all new compounds was elucidated by NMR and MS spectroscopy. Electrophilic substitution, mainly nitration, of the various compounds was undertaken and the substitution positions determined. A series of derivatives was

  通过在仿生反应中使萘醌、胡桃酮或环己烷-1,3-二酮与β, β'-二氨基酮反应，合成了几种新的吡啶并[2,3,4-kl]吖啶。所有新化合物的结构都通过 NMR 和 MS 光谱进行了阐明。对各种化合物进行亲电取代，主要是硝化作用，并确定取代位置。制备了一系列衍生物并分析了它们对 P-388 小鼠淋巴瘤细胞的细胞毒性。发现最具细胞毒性的衍生物具有 0.05 和 0.1 ug/ml 的 IC50。
• Acidic o-nitroaromatics as photoinhibitors of polymerization in positive
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US04477556A1

  公开（公告）日：1984-10-16

  A photopolymerizable coating composition comprising (1) a nongaseous, ethylenically unsaturated, polymerizable compound, (2) a specified acidic o-nitroaromatic compound, and (3) an organic, radiation-sensitive, free-radical generating system which is useful for making a positive or negative polymeric image on a substrate.

  一种光聚合涂层组合物，包括（1）一种非气态的、乙烯基不饱和的、可聚合的化合物，（2）一种特定的酸性邻硝基芳香化合物，和（3）一种有机的、辐射敏感的、自由基产生系统，用于在基底上制作正像或负像的聚合物图像。