(2-oxo-tetrahydro-[3]furyl)-acetic acid | 13281-16-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (2-oxo-tetrahydro-[3]furyl)-acetic acid
• 英文别名: (2-Oxo-tetrahydro-[3]furyl)-essigsaeure；2-(2-Oxooxolan-3-yl)acetic acid
• CAS: 13281-16-8
• 化学式: C₆H₈O₄
• mdl: MFCD19230045
• 分子量: 144.127
• InChiKey: OQAOJHDQOKLLKC-UHFFFAOYSA-N

物化性质

• 熔点：
  55-58 °C
• 沸点：
  402.3±18.0 °C(Predicted)
• 密度：
  1.328±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-oxo-tetrahydro-[3]furyl)-acetic acid 、 1-氯-N,N,2-三甲基丙烯胺 生成 2-(2-Oxooxolan-3-yl)acetyl chloride
  参考文献：
  名称：

  CAPRARO, HANS-GEORG;FRANCOTTE, ERIC;KOHLER, BORIS;RIHS, GRETHY;SCHNEIDER,+, J. ANTIBIOTICS, 41,(1988) N 6, 759-770

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 (2-oxo-tetrahydro-[3]furyl)-acetic acid
  参考文献：
  名称：

  McRae et al., Canadian Journal of Research, Section B: Chemical Sciences, 1943, vol. 21, p. 186,191

  摘要：

  DOI：

文献信息

• Continuous-Flow Preparation of γ-Butyrolactone Scaffolds from Renewable Fumaric and Itaconic Acids under Photosensitized Conditions
  作者：Romaric Gérardy、Marc Winter、Clemens R. Horn、Alessandra Vizza、Kristof Van Hecke、Jean-Christophe M. Monbaliu

  DOI：10.1021/acs.oprd.7b00314

  日期：2017.12.15

  lab-scale mesofluidic reactor connected with an in-line NMR spectrometer for real-time reaction monitoring. Substituted γ-butyrolactones, including spiro derivatives with unique structural features, were obtained with quantitative conversion of the starting materials and in 47–76% isolated yields. The model photoaddition of isopropanol to fumaric acid was next successfully transposed in a pilot-scale continuous-flow

  本文所述的方法和结果涉及在玻璃微流体反应器和中流体反应器中在可缩放的连续流条件下向可再生平台富马酸和衣康酸中光敏加成各种醇。酒精既用作试剂又用作溶剂，因此有助于减少环境足迹。在微流体条件下评估温度，光强度，光敏剂的性质和数量等工艺参数，然后将其转移到实验室规模的中流体反应器中，该反应器与在线NMR光谱仪连接以进行实时反应监控。取代后的γ-丁内酯（包括具有独特结构特征的螺衍生物）是通过原料的定量转化获得的，分离产率为47-76％。
• COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20210289794A1

  公开（公告）日：2021-09-23

  The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.
• US4178213A
  申请人：——

  公开号：US4178213A

  公开（公告）日：1979-12-11
• US7556908B2
  申请人：——

  公开号：US7556908B2

  公开（公告）日：2009-07-07
• WO2022/233906
  申请人：——

  公开号：——

  公开（公告）日：——