4-(2-(4-aminophenoxy)pyridin-3-yl)-N-methylpyrimidin-2-amine | 870221-86-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-(2-(4-aminophenoxy)pyridin-3-yl)-N-methylpyrimidin-2-amine
• 英文别名: 4-[2-(4-aminophenoxy)pyridin-3-yl]-N-methylpyrimidin-2-amine
• CAS: 870221-86-6
• 化学式: C₁₆H₁₅N₅O
• 分子量: 293.328
• InChiKey: BMOQGHOCXJZTKR-UHFFFAOYSA-N

物化性质

• 沸点：
  533.1±60.0 °C(Predicted)
• 密度：
  1.293±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  86
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-(2-(4-aminophenoxy)pyridin-3-yl)-N-methylpyrimidin-2-amine 在 polymer-supported carbodiimide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 N-[4-({3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl}oxy)phenyl]-1H-benzimidazol-2-amine
  参考文献：
  名称：

  Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase

  摘要：

  Selective small molecule inhibitors of Tie-2 kinase are important tools for the validation of Tie-2 signaling in pathological angiogenesis. Reported herein is the optimization of a nonselective scaffold into a potent and highly selective inhibitor of Tie-2 kinase.

  DOI：

  10.1016/j.bmcl.2008.11.056
• 作为产物：
  描述：

  4-(2-氯-3-吡啶)-n-甲基-2-嘧啶胺 、 对氨基苯酚 在 caesium carbonate 作用下， 以 二甲基亚砜 为溶剂， 生成 4-(2-(4-aminophenoxy)pyridin-3-yl)-N-methylpyrimidin-2-amine
  参考文献：
  名称：

  Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase

  摘要：

  Selective small molecule inhibitors of Tie-2 kinase are important tools for the validation of Tie-2 signaling in pathological angiogenesis. Reported herein is the optimization of a nonselective scaffold into a potent and highly selective inhibitor of Tie-2 kinase.

  DOI：

  10.1016/j.bmcl.2008.11.056

文献信息

• Aurora kinase modulators and method of use
  申请人：Cee J. Victor

  公开号：US20070185111A1

  公开（公告）日：2007-08-09

  The present invention relates to chemical compounds having a general formula I wherein A 1 , A 2 , C 1 , C 2 , D, L 1 , L 2 , Z and R 1 - are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

  本发明涉及具有一般式I的化合物，其中A1、A2、C1、C2、D、L1、L2、Z和R1-在此定义，并且具有调节各种蛋白激酶受体酶的能力，从而影响与这些激酶活动相关的各种疾病状态和病况。例如，这些化合物能够调节枢纽激酶，从而影响细胞周期和细胞增殖过程，用于治疗癌症和癌症相关疾病。该发明还包括含有这些化合物的药物组合物，以及治疗与枢纽激酶活性相关的疾病状态的方法。
• Multi-cyclic compound and method of use
  申请人：Cee J. Victor

  公开号：US20070213325A1

  公开（公告）日：2007-09-13

  The present invention relates to chemical compounds having a general formula I wherein A, B, C 1 , C 2 , D, L 1 , L 2 and R 3-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Tie-2 and Aurora kinase enzymes thereby influencing angiogenesis and the process of cell cycle and cell proliferation, respectively, to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of various protein kinases.

  本发明涉及具有一般公式I的化合物，其中A、B、C1、C2、D、L1、L2和R3-4在此处定义，并且合成中间体，能够调节各种蛋白激酶受体酶，从而影响与这些激酶活动相关的各种疾病状态和状况。例如，这些化合物能够调节Tie-2和Aurora激酶酶，从而影响血管生成以及细胞周期和细胞增殖过程，以治疗癌症和癌症相关疾病。本发明还包括包括这些化合物的药物组合物，以及治疗与各种蛋白激酶活动相关的疾病状态的方法。
• Protein kinase modulators and method of use
  申请人：Geuns-Meyer D. Stephanie

  公开号：US20060009453A1

  公开（公告）日：2006-01-12

  The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H 1-5 and R 1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.

  本发明涉及具有通式I的化合物，其中A、B、D、E、G、H1-5和R1-4在此定义，并且合成中间体，这些化合物能够调节各种蛋白激酶受体酶，从而影响与这些激酶活性相关的各种疾病状态和条件。例如，这些化合物能够调节激酶酶，从而影响血管生成的过程，并治疗与血管生成相关的疾病和其他增生性疾病，包括癌症和炎症。本发明还包括包括这些化合物的药物组合物和治疗与蛋白激酶活性相关的疾病状态的方法。
• Multi-cyclic compounds and method of use
  申请人：Amgen Inc.

  公开号：US07868177B2

  公开（公告）日：2011-01-11

  The present invention relates to chemical compounds having a general formula I wherein A, B, C1, C2, D, L1, L2 and R3-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Tie-2 and Aurora kinase enzymes thereby influencing angiogenesis and the process of cell cycle and cell proliferation, respectively, to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of various protein kinases.

  本发明涉及具有一般式I的化合物，其中A、B、C1、C2、D、L1、L2和R3-4在此定义，并且合成中间体，能够调节各种蛋白激酶受体酶，从而影响与这些激酶活性相关的各种疾病状态和条件。例如，这些化合物能够调节Tie-2和Aurora激酶酶，从而影响血管生成以及细胞周期和细胞增殖过程，以治疗癌症和癌症相关疾病。本发明还包括包括这些化合物的制药组合物以及治疗与各种蛋白激酶活性相关的疾病状态的方法。
• PROTEIN KINASE MODULATORS AND METHOD OF USE
  申请人：GEUNS-MEYER Stephanie D.

  公开号：US20110201602A1

  公开（公告）日：2011-08-18

  The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H 1-5 and R 1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.

  本发明涉及具有一般式I的化合物，其中A、B、D、E、G、H1-5和R1-4在此定义，并且合成中间体，这些化合物能够调节各种蛋白激酶受体酶，并因此影响与这些激酶活性相关的各种疾病状态和条件。例如，这些化合物能够调节激酶酶，从而影响血管生成过程，治疗与血管生成相关的疾病和其他增殖性疾病，包括癌症和炎症。本发明还包括包括这些化合物的制药组合物和治疗与蛋白激酶活性相关的疾病状态的方法。