3-Butoxy-2,2-dimethyl-cyclobutanon | 2292-83-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Butoxy-2,2-dimethyl-cyclobutanon
• 英文别名: 3-Butoxy-2,2-dimethylcyclobutan-1-one
• CAS: 2292-83-3
• 化学式: C₁₀H₁₈O₂
• mdl: MFCD21602624
• 分子量: 170.252
• InChiKey: KMPAHCHXLPFRLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二甲基乙烯酮 、 乙烯基正丁醚 生成 3-Butoxy-2,2-dimethyl-cyclobutanon
  参考文献：
  名称：

  Ketenes. II. Cycloaddition of Dialkyl Ketenes to Vinyl Ethers¹

  摘要：

  DOI：

  10.1021/jo01028a061

文献信息

• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR
  申请人：Arvinas, Inc.

  公开号：US20170327469A1

  公开（公告）日：2017-11-16

  The present disclosure relates to bifunctional compounds, which find utility to degrade (and inhibit) Androgen Receptor. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds Androgen Receptor such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of Androgen Receptor.
• Ketenes. II. Cycloaddition of Dialkyl Ketenes to Vinyl Ethers¹
  作者：Robert H. Hasek、P. Glenn Gott、James C. Martin

  DOI：10.1021/jo01028a061

  日期：1964.5

表征谱图