(+/-)-cis-4b.5.6.10b.11.12-hexahydro-chrysene | 31579-69-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (+/-)-cis-4b.5.6.10b.11.12-hexahydro-chrysene
• 英文别名: (+/-)-cis-4b.5.6.10b.11.12-Hexahydro-chrysen；cis-4b,5,6,10b,11,12-Hexahydro-chrysen；(4bS,10bS)-4b,5,6,10b,11,12-hexahydrochrysene
• CAS: 31579-69-8；31579-70-1；92082-65-0
• 化学式: C₁₈H₁₈
• 分子量: 234.341
• InChiKey: QEPVMZBHTZAQMT-QZTJIDSGSA-N

物化性质

• 熔点：
  77-78 °C
• 沸点：
  359.4±42.0 °C(Predicted)
• 密度：
  1.074±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (+/-)-cis-4b.5.6.10b.11.12-hexahydro-chrysene 、 alkaline earth salt of/the/ methylsulfuric acid 生成 屈
  参考文献：
  名称：

  The role of M cells in mucosal immunity

  摘要：

  Mucosa-associated lymphoid tissue in the respiratory and digestive tracts are covered by a specialized epithelium, the follicle-associated epithelium, which includes M cells, which are specialized for the uptake and transcytosis of macromolecules and microorganisms. Following transcytosis, antigens are released to cells of the immune system in lymphoid aggregates beneath the epithelium where antigen processing and presentation and stimulation of specific B and T lymphocytes are achieved. Circulation of the lymphoid cells enables their homing to their original, and other, mucosal sites where they exert the effector function. Such a response may be dominated by secretory immunoglobulin A release and may include cytotoxic T lymphocyte action. Binding of particles to the apical M cell membrane may be nonspecific or due to specific interaction between molecules such as integrins and lectins. Exploiting the specific binding to M cells is an aim for mucosal vaccination, for example to increase the efficiency of uptake of an oral vaccine by its conjugation to an M-cel-specific molecule. Alternatively, an M-cell-specific live vector, such as attenuated Salmonella bacteria, may be used to deliver epitopes of other organisms. Mucosal vaccination efficiency may also be enhanced by a temporary increase in the number of M cells.Therefore, investigation of the properties and ontogeny of M cells must be pursued to allow the development of better mucosal vaccines for the future.

  DOI：

  10.1007/pl00000693
• 作为产物：
  描述：

  5,6,11,12-四氢屈 在 氨 、 lithium 作用下， 以 四氢呋喃 为溶剂， 生成 (+/-)-cis-4b.5.6.10b.11.12-hexahydro-chrysene
  参考文献：
  名称：

  Metal-ammonia reduction. XI. Regiospecific and stereoselective reduction in the chrysene series

  摘要：

  DOI：

  10.1021/jo00821a009

文献信息

• 79. Symmetrical derivatives of chrysene. Part I
  作者：G. R. Ramage

  DOI：10.1039/jr9380000397

  日期：——
• A New Synthesis of Chrysene Derivatives
  作者：Melvin S. Newman

  DOI：10.1021/ja01279a034

  日期：1938.12
• 194. A modified synthesis of chrysene
  作者：G. M. Badger

  DOI：10.1039/jr9480000999

  日期：——
• v. Braun; Irmisch, Chemische Berichte, 1931, vol. 64, p. 2461,2464
  作者：v. Braun、Irmisch

  DOI：——

  日期：——
• Metal-ammonia reduction. XI. Regiospecific and stereoselective reduction in the chrysene series
  作者：Ronald G. Harvey

  DOI：10.1021/jo00821a009

  日期：1971.11