2,2-二氯环丙烷-1-羧酰胺 | 75885-60-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2,2-二氯环丙烷-1-羧酰胺
• 英文名称: 2,2-dichlorocyclopropanecarboxamide
• 英文别名: 2,2-Dichlorocyclopropane-1-carboxamide
• CAS: 75885-60-8
• 化学式: C₄H₅Cl₂NO
• mdl: MFCD00218854
• 分子量: 153.996
• InChiKey: POUMCBWMYUEVKF-UHFFFAOYSA-N

物化性质

• 熔点：
  148-149°C

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2924299090

SDS

Name:	2 2-Dichlorocyclopropanecarboxamide 97% Material Safety Data Sheet
Synonym:	2,2-Dichlorocyclopropane-1-carboxamid
CAS:	75885-60-8

Section 1 - Chemical Product MSDS Name:2 2-Dichlorocyclopropanecarboxamide 97% Material Safety Data Sheet
Synonym:2,2-Dichlorocyclopropane-1-carboxamid

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
75885-60-8	2,2-Dichlorocyclopropanecarboxamide	97%	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 75885-60-8: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: off-white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 148 - 149 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C4H5Cl2NO
Molecular Weight: 154

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, carbon dioxide, acrid smoke and fumes.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 75885-60-8 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2,2-Dichlorocyclopropanecarboxamide - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 75885-60-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 75885-60-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 75885-60-8 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2,2-二氯环丙烷-1-羧酰胺 在 五氯化磷 作用下， 以80%的产率得到2,2-二氯环丙烷-1-甲腈
  参考文献：
  名称：

  Kulinkovich, O. G.; Tishchenko, I. G.; Romashin, Yu. N., Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 213 - 216

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2-二氯环丙烷羰基氯化物 在 ammonium hydroxide 作用下， 以80%的产率得到2,2-二氯环丙烷-1-羧酰胺
  参考文献：
  名称：

  Kulinkovich, O. G.; Tishchenko, I. G.; Romashin, Yu. N., Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 213 - 216

  摘要：

  DOI：

文献信息

• [EN] PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS<br/>[FR] DÉRIVÉS PYRROLIDINE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE LA VOIE DU COMPLÉMENT
  申请人：NOVARTIS AG

  公开号：WO2014002054A1

  公开（公告）日：2014-01-03

  The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种化合物(I)的方法，用于制造该发明的化合物，并将其用作眼部疾病治疗的补体途径调节剂。本发明还提供了一种药理活性剂的组合和制药组合物。
• Thienamycin renal peptidase inhibitors
  申请人：Merck & Co., Inc.

  公开号：US05147868A1

  公开（公告）日：1992-09-15

  Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are z-2-acylamino-3-monosubstituted propenoates.

  提供了一种新颖的化学化合物，可以选择性地抑制二肽酶（E.C.3.4.13.11）的代谢，因此与抗菌产品结合使用时具有用处。这些化学化合物是z-2-酰氨基-3-单取代丙烯酸酯。
• Combination of thienamycin-type antibiotics with dipeptidase inhibitors
  申请人：Merck & Co., Inc.

  公开号：US04539208A1

  公开（公告）日：1985-09-03

  A novel antibacterial drug combination is provided, one component being a fused ring .beta.-lactam, such as thienamycin and its semi-synthetic derivatives, and the other component is a dipeptidase (E.C. 3.4.13.11) inhibitor. The dual-component combination is formulated so that 1 to 3 parts by weight of the .beta.-lactam compound are employed for 30 to 1 parts by weight of the inhibitor compound.

  提供了一种新型抗菌药物组合，其中一个成分是融合环β-内酰胺，如噻呋霉素及其半合成衍生物，另一个成分是二肽酶（E.C. 3.4.13.11）抑制剂。双组分组合物的配方使得β-内酰胺化合物的重量为1至3份，而抑制剂化合物的重量为30至1份。
• Use of substituted propenoates to prevent nephrotoxicity of certain
  申请人：Merck & Co., Inc.

  公开号：US04668504A1

  公开（公告）日：1987-05-26

  Antibiotics to prevent nephrotoxicity.

  使用抗生素以预防肾毒性。
• Combination of 2-substituted carbapenems with dipeptidase inhibitors
  申请人：Merck & Co., Inc.

  公开号：US05071843A1

  公开（公告）日：1991-12-10

  A combination of a carbapenem of the formula: ##STR1## where R is H or CH.sub.3 and R.sup.1 is ##STR2## with a renal dipeptidase inhibitor is disclosed.

  本发明揭示了一种将式子为##STR1##的碳青霉烯类抗生素（其中R为H或CH.sub.3，R.sup.1为##STR2##）与肾脏二肽酶抑制剂结合使用的方法。