[2-(3-Cyclopentyloxy-4-methoxyphenyl)-5-pyridin-2-ylfuran-3-yl]-phenylmethanol | 222962-07-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [2-(3-Cyclopentyloxy-4-methoxyphenyl)-5-pyridin-2-ylfuran-3-yl]-phenylmethanol
• CAS: 222962-07-4
• 化学式: C₂₈H₂₇NO₄
• 分子量: 441.527
• InChiKey: GLPDAFVUMKTCNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  64.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [2-(3-Cyclopentyloxy-4-methoxyphenyl)-5-pyridin-2-ylfuran-3-yl]-phenylmethanol 在 manganese(IV) oxide 作用下， 以 乙酸乙酯 为溶剂， 生成 3-Benzoyl-2-(3-cyclopentyloxy-4-methoxyphenyl)-5-(pyridin-2-yl)furan
  参考文献：
  名称：

  Substituted furans as inhibitors of the PDE4 enzyme

  摘要：

  The synthesis and in vitro activity of a series of substituted furans as a novel structural class of PDE4 inhibitors is described. Comparison of emetic threshold with known PDE4 inhibitors is presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00742-2
• 作为产物：
  描述：

  在 manganese(IV) oxide 、 正丁基锂 、 ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide 、 对甲苯磺酸 、 三乙胺 作用下， 以 乙酸乙酯 、 甲苯 为溶剂， 反应 2.0h， 生成 [2-(3-Cyclopentyloxy-4-methoxyphenyl)-5-pyridin-2-ylfuran-3-yl]-phenylmethanol
  参考文献：
  名称：

  Substituted furans as inhibitors of the PDE4 enzyme

  摘要：

  The synthesis and in vitro activity of a series of substituted furans as a novel structural class of PDE4 inhibitors is described. Comparison of emetic threshold with known PDE4 inhibitors is presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00742-2

文献信息

• Substituted furans as inhibitors of the PDE4 enzyme
  作者：Hélène Perrier、Christopher Bayly、France Laliberté、Zheng Huang、Roberta Rasori、Annette Robichaud、Yves Girard、Dwight Macdonald

  DOI：10.1016/s0960-894x(98)00742-2

  日期：1999.2

  The synthesis and in vitro activity of a series of substituted furans as a novel structural class of PDE4 inhibitors is described. Comparison of emetic threshold with known PDE4 inhibitors is presented. (C) 1999 Elsevier Science Ltd. All rights reserved.