ethyl iodomethylphosphonic acid | 494209-74-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl iodomethylphosphonic acid
• 英文别名: monoethyl iodomethylphosphonate；iodomethylphosphonic acid monoethyl ester；Jodmethyl-phosphonsaeure-monoaethylester；Ethoxy(iodomethyl)phosphinic acid
• CAS: 494209-74-4
• 化学式: C₃H₈IO₃P
• 分子量: 249.973
• InChiKey: XKSREKGVEMJLJJ-UHFFFAOYSA-N

物化性质

• 熔点：
  46-49 °C(Solv: carbon tetrachloride (56-23-5); ligroine (8032-32-4))
• 沸点：
  267.4±42.0 °C(Predicted)
• 密度：
  2.001±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl iodomethylphosphonic acid 在 N,N'-二环己基碳二亚胺 作用下， 以 乙醚 为溶剂， 生成 Ethyl-iodmethylphosphonsaeure-anhydrid
  参考文献：
  名称：

  Synthesis of a Series of Organophosphorus Esters Containing Alkylating Groups¹

  摘要：

  DOI：

  10.1021/jo01068a082
• 作为产物：
  描述：

  碘甲基膦酸二乙酯 在 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 生成 ethyl iodomethylphosphonic acid
  参考文献：
  名称：

  Synthesis of a Series of Organophosphorus Esters Containing Alkylating Groups¹

  摘要：

  DOI：

  10.1021/jo01068a082

文献信息

• Synthesis and antiherpetic activity of (Z)- and (E)-9-(3-phosphonomethoxyprop-1-en-yl)adenines
  作者：A. V. Ivanov、V. L. Andronova、G. A. Galegov、M. V. Jasko

  DOI：10.1007/s11171-005-0007-7

  日期：2005.1

  9-(3-Phosphonomethoxyprop-1-en-yl)adenine (Z)- and (E)-isomers were synthesized. The stereoselectivity of double bond formation was studied by variation of sulfonyl groups. The resulting phosphonates exhibited a moderate antiherpetic activity in a culture of Vero cells infected with herpes simplex type 1 virus. The Z-isomer was shown to be more effective inhibitor of virus reproduction in the case

  合成了9-（3-膦氧基甲氧基丙-1-烯基）腺嘌呤（Z）-和（E）-异构体。通过改变磺酰基来研究双键形成的立体选择性。所得的膦酸酯在感染了单纯疱疹1型病毒的Vero细胞培养物中显示出中等的抗疱疹活性。在野生株和对阿昔洛韦有抗性的菌株中，Z-异构体均被证明是更有效的病毒繁殖抑制剂。
• Synthesis of geminal-substituted, sterically congested, proton-ionizable dibenzo-14-crown-4, dibenzo-16-crown-5, dibenzo-19-crown-6 and dibenzo-22-crown-7 lariat ethers
  作者：Dongmei Zhang、Xiaodong Liu、Sharon L. Williams、Chunkyung Park、Richard A. Bartsch

  DOI：10.3998/ark.5550190.0011.704

  日期：——

  -16-crown-5, -19-crown-6 and -22-crown-7 lariat ethers with different lipophilic geminal alkyl groups and different proton-ionizable groups are synthesized. For each lariat ether platform, butyl, heptyl and decyl groups were incorporated as the geminal lipophilic groups. Carboxylic acid, N-(trifluoromethane)sulfonyl carboxamide and sodium 3-propanesulfonate groups are incorporated on the platforms as proton-ionizable

  合成了具有不同亲脂性孪生烷基和不同质子可电离基团的可质子二苯并-14-冠-4、-16-冠-5、-19-冠-6和-22-冠-7套索醚。对于每个套索醚平台，丁基、庚基和癸基作为孪生亲脂基团并入。羧酸、N-（三氟甲烷）磺酰甲酰胺和 3-丙磺酸钠基团作为可质子电离的官能团并入平台。
• Ion Flotation of Cadmium(II) and Zinc(II) in the Presence of Proton-Ionizable Lariat Ethers
  作者：Malgorzata Ulewicz、Wladyslaw Walkowiak、Youngchan Jang、Jong Seung Kim、Richard A. Bartsch

  DOI：10.1021/ac026322y

  日期：2003.5.1

  Competitive flotation of Cd(II) and Zn(II) from very dilute aqueous solutions by proton-ionizable lariat ethers in the presence of nonylphenol nona(ethylene glycol) ether as a nonionic foaming agent is reported. Influences of structural variation within the collector (identity of the pendent acidic group and lipophilicity), concentration of the collector, and pH of the aqueous solution are assessed

  据报道，在壬基酚壬二（乙二醇）醚作为非离子型发泡剂的存在下，质子可离子化的套索状醚从极稀的水溶液中竞争性地浮选Cd（II）和Zn（II）。评估收集器内结构变化的影响（悬垂的酸性基团和亲脂性），收集器的浓度和水溶液的pH值。发现单乙基套索状醚膦酸收集剂在某些条件下具有高的Cd（II）/ Zn（II）浮选选择性。
• New benzophenone phosphonate derivatives
  作者：Maxim S. Gaman、Elena S. Matyugina、Mikhail S. Novikov、Denis A. Babkov、Pavel N. Solyev、Sergey N. Kochetkov、Anastasia L. Khandazhinskaya

  DOI：10.1016/j.mencom.2017.07.008

  日期：2017.7

  New well-soluble in 10% DMSO phosphonate derivatives of substituted benzophenone have been synthesized using different methods. Preliminary computer modeling of proposed structures in the reverse transcriptase HIV-1 hydrophobic pocket suggested these molecules as potential non-nucleoside inhibitors of this enzyme.
• Synthetic plant hormones. Part III. Aryloxymethylphosphonates
  作者：M. H. Maguire、G. Shaw

  DOI：10.1039/jr9550001756

  日期：——