1,5-Dimethyl-4-nitropyrrole-2-carboxylic acid | 72795-81-4

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 1,5-Dimethyl-4-nitropyrrole-2-carboxylic acid
• 英文别名: 4-nitro-5-methyl-1-methylpyrrole-2-carboxylic acid；1,5-Dimethyl-4-nitropyrrol-2-carbonsaeure
• CAS: 72795-81-4
• 化学式: C₇H₈N₂O₄
• 分子量: 184.152
• InChiKey: HLMFHARHIFIMNC-UHFFFAOYSA-N

物化性质

• 沸点：
  366.2±42.0 °C(Predicted)
• 密度：
  1.46±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  88
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,5-Dimethyl-4-nitropyrrole-2-carboxylic acid 在 喹啉 、 铜 作用下， 反应 1.0h， 以86%的产率得到1,2-二甲基-3-硝基吡咯
  参考文献：
  名称：

  Synthesis and nucleophilic properties of 1,2-dialkyl-3-nitropyrroles and 1,5-dialkyl-4-nitropyrrole-2-carboxylic acid derivatives

  摘要：

  1,2-Dialkyl-3-nitropyrroles 1 are versatile synthetic tools for obtaining substituted pyrrolidines or fused ring heterocycles such as pyrrolopyridines, pyrrolopyrimidines or pyrroloazepines. We have established a method for obtaining compounds related to structure 1 and studied the reactivity as a nucleophile of the benzylic type moiety in the alkyl residue bound to position 2.

  DOI：

  10.1039/p19960002277
• 作为产物：
  描述：

  2-甲基吡咯 在 氢氧化钾 、 sodium hydroxide 、 硝酸 、 sodium ethanolate 作用下， 以 乙醚 、 乙醇 、 二甲基亚砜 为溶剂， 反应 5.5h， 生成 1,5-Dimethyl-4-nitropyrrole-2-carboxylic acid
  参考文献：
  名称：

  Synthesis and nucleophilic properties of 1,2-dialkyl-3-nitropyrroles and 1,5-dialkyl-4-nitropyrrole-2-carboxylic acid derivatives

  摘要：

  1,2-Dialkyl-3-nitropyrroles 1 are versatile synthetic tools for obtaining substituted pyrrolidines or fused ring heterocycles such as pyrrolopyridines, pyrrolopyrimidines or pyrroloazepines. We have established a method for obtaining compounds related to structure 1 and studied the reactivity as a nucleophile of the benzylic type moiety in the alkyl residue bound to position 2.

  DOI：

  10.1039/p19960002277

文献信息

• Distamycin Analogues with Enhanced Lipophilicity:  Synthesis and Antimicrobial Activity
  作者：Abedawn I. Khalaf、Roger D. Waigh、Allan J. Drummond、Breffni Pringle、Ian McGroarty、Graham G. Skellern、Colin J. Suckling

  DOI：10.1021/jm031089x

  日期：2004.4.1

  Forty-eight heterocyclic amino acid trimers, analogues of distamycin, with a number of features that enhance lipophilicity are described. They contain alkyl or cycloalkyl groups larger than methyl; some are N-terminated by acetamide or methoxybenzamide and are C-terminated by dimethylaminopropyl or aliphatic heterocylic aminopropyl substituents. The ability of these compounds to bind principally to

  描述了四十八个杂环氨基酸三聚体，它是二霉素的类似物，具有许多增强亲脂性的特征。它们含有比甲基大的烷基或环烷基；一些被乙酰胺或甲氧基苯甲酰胺N端基，并且被二甲氨基丙基或脂族杂环甲基氨基丙基取代基C端基。使用毛细管区带电泳已经评估了这些化合物主要结合至DNA AT束的能力。几种化合物，特别是那些含有噻唑的化合物，显示出对关键生物如MRSA和白色念珠菌的显着抗菌活性。而且，这些化合物对几种哺乳动物细胞系具有低毒性。
• GREHN L., CHEM. SCR., 1978-1979, 13, NO 2-3, 67-77
  作者：GREHN L.

  DOI：——

  日期：——
• Synthesis and nucleophilic properties of 1,2-dialkyl-3-nitropyrroles and 1,5-dialkyl-4-nitropyrrole-2-carboxylic acid derivatives
  作者：Antoni M. Molins-Pujol、Concepció Moranta、Carmina Arroyo、M. Teresa Rodríguez、M. Carmen Meca、M. Dolors Pujol、Joaquim Bonal

  DOI：10.1039/p19960002277

  日期：——

  1,2-Dialkyl-3-nitropyrroles 1 are versatile synthetic tools for obtaining substituted pyrrolidines or fused ring heterocycles such as pyrrolopyridines, pyrrolopyrimidines or pyrroloazepines. We have established a method for obtaining compounds related to structure 1 and studied the reactivity as a nucleophile of the benzylic type moiety in the alkyl residue bound to position 2.