5-acetyl-2-mercapto-4-phenylthiazole

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-acetyl-2-mercapto-4-phenylthiazole
• 英文别名: 1-(4-phenyl-2-sulfanylidene-3H-1,3-thiazol-5-yl)ethanone
• 化学式: C₁₁H₉NOS₂
• 分子量: 235.331
• InChiKey: UXNLFGNHKLUDIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  86.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-苯基-1,3-丁二酮 以 水 、 乙腈 为溶剂， 反应 3.25h， 生成 5-acetyl-2-mercapto-4-phenylthiazole
  参考文献：
  名称：

  HYPERVALENT IODINE IN SYNTHESIS. 48. A ONE-POT CONVENIENT PROCEDURE FOR THE SYNTHESIS OF 2-MERCAPTOTHIAZOLES BY CYCLOCONDENSATION OF KETONES WITH [HYDROXY(TOSYLOXY)IODO]-BENZENE AND AMMONIUM DITHIOCARBAMATE

  摘要：

  alpha -Tosyloxylation of ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB), followed by treatment with ammonium dithiocarbamate, provides a one-pot convenient procedure for the synthesis of 2-mercaptethiazoles with good yields.

  DOI：

  10.1081/scc-100000532

文献信息

• PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5-MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS
  申请人：Flynn Gary A.

  公开号：US20140228367A1

  公开（公告）日：2014-08-14

  The present disclosure relates to compounds of the Formula (I): and pharmaceutically acceptable salts, as kinase modulators, compatible with the Type-II inhibition of kinases.

  本公开涉及式（I）的化合物及其药学上可接受的盐，作为酶调节剂，与激酶的II型抑制相兼容。
• US9221805B2
  申请人：——

  公开号：US9221805B2

  公开（公告）日：2015-12-29
• HYPERVALENT IODINE IN SYNTHESIS. 48. A ONE-POT CONVENIENT PROCEDURE FOR THE SYNTHESIS OF 2-MERCAPTOTHIAZOLES BY CYCLOCONDENSATION OF KETONES WITH [HYDROXY(TOSYLOXY)IODO]-BENZENE AND AMMONIUM DITHIOCARBAMATE
  作者：Peng-Fei Zhang、Zhen-Chu Chen

  DOI：10.1081/scc-100000532

  日期：2001.1

  alpha -Tosyloxylation of ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB), followed by treatment with ammonium dithiocarbamate, provides a one-pot convenient procedure for the synthesis of 2-mercaptethiazoles with good yields.