4-(furan-2-yl)-1H-pyrrole-3-carboxylic acid | 1188029-07-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-(furan-2-yl)-1H-pyrrole-3-carboxylic acid
• CAS: 1188029-07-3
• 化学式: C₉H₇NO₃
• mdl: MFCD11217990
• 分子量: 177.159
• InChiKey: APFSDBYQIKDVJM-UHFFFAOYSA-N

物化性质

• 沸点：
  370.4±32.0 °C(Predicted)
• 密度：
  1.380±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-氯苯磺酰胺 、 4-(furan-2-yl)-1H-pyrrole-3-carboxylic acid 在 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以76%的产率得到N-(4-furan-2-yl-1H-pyrrole-3-carbonyl)-4-chlorobenzenesulfonamide
  参考文献：
  名称：

  Synthesis and antimicrobial activity of some new amido/sulfonamido-linked 3,4-disubstituted pyrroles

  摘要：

  A new series of pyrrolyl carboxamides, pyrrolyl sulfonamides, and pyrrolyl pyrimidine derivatives were prepared from simple starting compounds-ethyl 3-phenylacrylate and ethyl 3-furanylacrylate under ultrasonication and screened for their antimicrobial activity. Among the tested compounds pyrrolyl pyrimidine derivatives and chloro-substituted pyrroles displayed excellent activity when compared to the other compounds. The chloro-substituted pyrrolyl sulfonamides are the potent antimicrobial agents particularly against P. aeruginosa and P. chrysogenum.

  DOI：

  10.1007/s00044-014-0908-1
• 作为产物：
  描述：

  环氧富锌底漆 在 sodium hydroxide 作用下， 以 四氢呋喃 、 乙醚 、 二甲基亚砜 为溶剂， 生成 4-(furan-2-yl)-1H-pyrrole-3-carboxylic acid
  参考文献：
  名称：

  Synthesis and antimicrobial activity of some new amido/sulfonamido-linked 3,4-disubstituted pyrroles

  摘要：

  A new series of pyrrolyl carboxamides, pyrrolyl sulfonamides, and pyrrolyl pyrimidine derivatives were prepared from simple starting compounds-ethyl 3-phenylacrylate and ethyl 3-furanylacrylate under ultrasonication and screened for their antimicrobial activity. Among the tested compounds pyrrolyl pyrimidine derivatives and chloro-substituted pyrroles displayed excellent activity when compared to the other compounds. The chloro-substituted pyrrolyl sulfonamides are the potent antimicrobial agents particularly against P. aeruginosa and P. chrysogenum.

  DOI：

  10.1007/s00044-014-0908-1

文献信息

• Synthesis and antimicrobial activity of some new amido/sulfonamido-linked 3,4-disubstituted pyrroles
  作者：Kaveri Syamaiah、Guda Mallikarjuna Reddy、Venkatapuram Padmavathi、Adivireddy Padmaja

  DOI：10.1007/s00044-014-0908-1

  日期：2014.7

  A new series of pyrrolyl carboxamides, pyrrolyl sulfonamides, and pyrrolyl pyrimidine derivatives were prepared from simple starting compounds-ethyl 3-phenylacrylate and ethyl 3-furanylacrylate under ultrasonication and screened for their antimicrobial activity. Among the tested compounds pyrrolyl pyrimidine derivatives and chloro-substituted pyrroles displayed excellent activity when compared to the other compounds. The chloro-substituted pyrrolyl sulfonamides are the potent antimicrobial agents particularly against P. aeruginosa and P. chrysogenum.