4-[2-(3-溴苯氧基)乙基]吗啉 | 435283-95-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-[2-(3-溴苯氧基)乙基]吗啉
• 中文别名: 4-(2-(3-溴苯氧基)-乙基)吗啡啉；4-(2-(3-溴苯氧基)乙基)吗啉
• 英文名称: 4-(2-(3-bromophenoxy)ethyl)morpholine
• 英文别名: 4-[2-(3-Bromophenoxy)ethyl]morpholine
• CAS: 435283-95-7
• 化学式: C₁₂H₁₆BrNO₂
• mdl: MFCD03710161
• 分子量: 286.169
• InChiKey: YZKFMBAOEVINLP-UHFFFAOYSA-N

物化性质

• 沸点：
  141 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险品标志：
  C
• 海关编码：
  2934999090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 4-[2-(3-Bromophenoxy)ethyl]morpholine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 4-[2-(3-Bromophenoxy)ethyl]morpholine
CAS number: 435283-95-7

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C12H16BrNO2
Molecular weight: 286.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-[2-(3-溴苯氧基)乙基]吗啉 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium acetate 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 32.0h， 生成 tert-butyl 1H-indazol-5-yl(2-(3-(2-morpholinoethoxy)phenyl)pyrimidin-4-yl)carbamate
  参考文献：
  名称：

  [EN] TREATMENT OF GVHD
  [FR] TRAITEMENT DE LA RÉACTION DU GREFFON CONTRE L'HÔTE

  摘要：

  这项发明涉及使用抑制ROCK2的化合物治疗移植物抗宿主病（GVHD）。在首选方面，本发明提供了治疗GVHD的方法，包括慢性GVHD（cGVHD），使用具有以下公式的化合物l-XXV。

  公开号：

  WO2015157556A1
• 作为产物：
  描述：

  2-吗啉乙醇 、 间溴苯酚 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 生成 4-[2-(3-溴苯氧基)乙基]吗啉
  参考文献：
  名称：

  [EN] MACROCYCLIC COMPOUNDS AND USES THEREOF
  [FR] COMPOSÉS MACROCYCLIQUES ET LEURS UTILISATIONS

  摘要：

  本文描述了一种式（I）的大环化合物，可以抑制EGFR等激酶，包括突变形式如T790M EGFR突变体。本文还描述了包括式（I）化合物或其任何药用可接受形式的药物组合物，其制备方法，以及在预防或治疗癌症的治疗中的用途。特别是，本文描述的化合物可以有效用于治疗EGFR驱动的癌症，包括非小细胞肺癌（NSCLC）。

  公开号：

  WO2021168074A1

文献信息

• PYRIDINE DERIVATIVES FOR THE TREATMENT OF AMYLOID-RELATED DISEASES
  申请人：Scopes David Ian Carter

  公开号：US20100298325A1

  公开（公告）日：2010-11-25

  a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof: wherein X and Y are independently NR 5 or O; W and Z are independently a bond or (CH2)mCH(R7)(CH2)n; m=0-1, n=0-2; R is hydrogen or halogen; R 1 and R 2 are independently selected from hydrogen halogen, CF 3 , CN, OR 8 , NR 9 R 10 , NR 9 COR 11 , NR 9 SO 2 R 11 or C 1-6 alkyl optionally substituted by hydroxyl, C 1-6 alkoxy or NR 9 R 10 ; R 3 is hydrogen, halogen, CF 3 , CN, OR 8 , SR 8 or SO 2 R 11 ; R 4 is hydrogen, halogen, CF 3 , OR 9 , NR 9 R 10 , NR 9 COR 11 , NR 9 SO 2 R 11 or C 1-6 alkyl optionally substituted by hydroxyl, C 1-6 alkoxy or NR 9 R 10 ; R 5 is hydrogen or C 1-6 alkyl optionally substituted by hydroxyl, C 1-6 alkoxy or NR 9 R 10 ; R6 is hydrogen, fluorine, C1-6 alkyl, or C1-6 alkoxy; R 6 is hydrogen, fluorine, C 1-6 alkyl, or C 1-6 alkoxy; R 7 is hydrogen, C 1-6 alkyl, phenyl or C 1-3 alkylphenyl wherein said phenyl groups are optionally substituted by one or more substituents selected from halogen, C 1-6 alkyl, CF 3 , OCF 3 or OR 9 ; R 8 is hydrogen or C 1-6 alkyl optionally substituted by fluorine, C 1-6 alkoxy or NR 9 R 10 , R 9 is hydrogen, C 1-6 alkyl or C 1-3 alkylphenyl wherein said phenyl group is optionally substituted by one or more substituents selected from halogen, C 1-6 alkyl, CF 3 , OR 8 , NR 9 R 10 Or OCF 3 ; R 10 is hydrogen, C 1-6 alkyl, C 1-6 alkenyl, phenyl or C 1-3 alkylphenyl wherein said phenyl groups are optionally substituted by one or more substituents selected from halogen, C 1-6 alkyl, CF 3 , OR 8 or OCF 3 ; or the groups R 9 and R 10 when they are attached to a nitrogen atom may together form a 5- or 6-membered ring which optionally contains one further heteroatom selected from NR 9 , S and O; and R 11 is C 1-6 alkyl or a phenyl group optionally substituted by one or more substituents selected from halogen, C 1-6 alkyl, CF 3 , OCF 3 or OR 8 is provided. The compounds are useful in treating amyloid related diseases.

  该化合物的结构式（I）或其药用可接受的盐或前药：其中X和Y分别独立为NR5或O；W和Z分别独立为键或（CH2）mCH(R7)(CH2)n；m=0-1，n=0-2；R为氢或卤素；R1和R2分别选自氢卤素，CF3，CN，OR8，NR9R10，NR9COR11，NR9SO2R11或C1-6烷基，可选择地被羟基，C1-6烷氧基或NR9R10取代；R3为氢，卤素，CF3，CN，OR8，SR8或SO2R11；R4为氢，卤素，CF3，OR9，NR9R10，NR9COR11，NR9SO2R11或C1-6烷基，可选择地被羟基，C1-6烷氧基或NR9R10取代；R5为氢或C1-6烷基，可选择地被羟基，C1-6烷氧基或NR9R10取代；R6为氢，氟，C1-6烷基或C1-6烷氧基；R7为氢，C1-6烷基，苯基或C1-3烷基苯基，其中所述苯基可选择地被一个或多个取代基取代，所述取代基选自卤素，C1-6烷基，CF3，OCF3或OR9；R8为氢或C1-6烷基，可选择地被氟，C1-6烷氧基或NR9R10取代；R9为氢，C1-6烷基或C1-3烷基苯基，其中所述苯基可选择地被一个或多个取代基取代，所述取代基选自卤素，C1-6烷基，CF3，OR8，NR9R10或OCF3；R10为氢，C1-6烷基，C1-6烯基，苯基或C1-3烷基苯基，其中所述苯基可选择地被一个或多个取代基取代，所述取代基选自卤素，C1-6烷基，CF3，OR8或OCF3；或当连接到氮原子时，R9和R10组合可形成一个可选择地含有来自NR9，S和O的进一步杂原子的5-或6-成员环；R11为C1-6烷基或一个苯基，可选择地被一个或多个取代基取代，所述取代基选自卤素，C1-6烷基，CF3，OCF3或OR8。这些化合物在治疗与淀粉样蛋白相关的疾病中很有用。
• COMPOUNDS USEFUL AS IMMUNOMODULATORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20170107202A1

  公开（公告）日：2017-04-20

  The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

  本发明公开一般涉及可用作免疫调节剂的化合物。本发明提供了化合物、包含此类化合物的组合物及其使用方法。本发明还涉及包含至少一种根据本发明的化合物的药物组合物，这些药物组合物可用于治疗各种疾病，包括癌症和传染病。
• TREATMENT OF OCULAR DISORDERS
  申请人：KADMON CORPORATION, LLC

  公开号：US20150238601A1

  公开（公告）日：2015-08-27

  The invention provides methods of treatment of ocular disorders, including ocular disease with an angiogenic component. In certain embodiments, the treatment comprises administration of a ROCK2 inhibitor and an angiogenesis inhibitor. In certain embodiments, the ROCK2 inhibitor is ROCK2 selective. In certain embodiments, the angiogenesis inhibitor is a VEGF antagonist, for example, and VEGFR2 antibody.

  本发明提供了治疗眼部疾病的方法，包括具有血管生成成分的眼部疾病。在某些实施例中，治疗包括给予ROCK2抑制剂和血管生成抑制剂。在某些实施例中，ROCK2抑制剂是ROCK2选择性的。在某些实施例中，血管生成抑制剂是VEGF拮抗剂，例如VEGFR2抗体。
• RHO KINASE INHIBITORS
  申请人：KADMON CORPORATION

  公开号：US20150252025A1

  公开（公告）日：2015-09-10

  The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCK1 and/or ROCK2.

  本发明涉及ROCK1和/或ROCK2的抑制剂。还提供了通过抑制ROCK1和/或ROCK2治疗涉及疾病和障碍的方法。
• Antimitotic amides for the treatment of cancer and proliferative disorders
  申请人：FROST BIOLOGIC, INC.

  公开号：US10016398B2

  公开（公告）日：2018-07-10

  Novel, antimitotic heteroaryl amides and pharmaceutically acceptable salts of Formula I where Ar, R5, R6, R8, R9, R11, X1, and X2 are as defined herein, as compounds for treatment and prevention of cancer and proliferative diseases and disorders.

  式 I 的新型抗拮抗杂芳基酰胺和药学上可接受的盐 其中 Ar、R5、R6、R8、R9、R11、X1 和 X2 如本文所定义，可用作治疗和预防癌症及增殖性疾病和紊乱的化合物。