Ethyl 1-acetyl-2,5-diphenylpyrrole-3-carboxylate | 1532520-93-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: Ethyl 1-acetyl-2,5-diphenylpyrrole-3-carboxylate
• 英文别名: ethyl 1-acetyl-2,5-diphenylpyrrole-3-carboxylate
• CAS: 1532520-93-6
• 化学式: C₂₁H₁₉NO₃
• 分子量: 333.387
• InChiKey: NMBHESHVFQINOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  48.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯乙酮肟 在 copper(l) iodide 、 copper diacetate 、 palladium diacetate 、 sodium hydrogensulfite 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 2-甲基-2-丁醇 、 1,2-二氯乙烷 为溶剂， 生成 Ethyl 1-acetyl-2,5-diphenylpyrrole-3-carboxylate
  参考文献：
  名称：

  Pd-Catalyzed Oxidative Coupling of Enamides and Alkynes for Synthesis of Substituted Pyrroles

  摘要：

  A novel and efficient palladium(II)-catalyzed alkenyl C-H activation oxidative annulation of enamides with alkynes for the synthesis of substituted pyrroles has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the synthesis of triaryl-substituted pyrroles in high yields.

  DOI：

  10.1021/ol403517p

文献信息

• Cobalt(<scp>iii</scp>)-catalyzed synthesis of pyrroles from enamides and alkynes
  作者：Wenlong Yu、Wei Zhang、Yue Liu、Yougui Zhou、Zhanxiang Liu、Yuhong Zhang

  DOI：10.1039/c6ra01992g

  日期：——

  An efficient and regioselective cobalt-catalyzed synthesis of multi-substituted pyrroles is reported by the use of readily available enamides and alkynes. The success of the process relies on the employment of a catalytic amount of Cp*Co(CO)I2 together with CuO as the oxidant.

  通过使用容易获得的酰胺和炔烃，报告了多取代吡咯的有效且区域选择性的钴催化的合成。该方法的成功取决于使用催化量的Cp * Co（CO）I 2和CuO作为氧化剂。
• Pd-Catalyzed Oxidative Coupling of Enamides and Alkynes for Synthesis of Substituted Pyrroles
  作者：Mi-Na Zhao、Zhi-Hui Ren、Yao-Yu Wang、Zheng-Hui Guan

  DOI：10.1021/ol403517p

  日期：2014.1.17

  A novel and efficient palladium(II)-catalyzed alkenyl C-H activation oxidative annulation of enamides with alkynes for the synthesis of substituted pyrroles has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the synthesis of triaryl-substituted pyrroles in high yields.