2,3-二氢-7-甲基-1H-茚-4-羧酸乙酯 | 71042-72-3

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 中文名称: 2,3-二氢-7-甲基-1H-茚-4-羧酸乙酯
• 中文别名: 乙基-7甲基-2,3-二氢-1H-茚-4-羧酸酯
• 英文名称: 4-(Ethoxycarbonyl)-7-methylindan
• 英文别名: ethyl 7-methyl-2,3-dihydro-1H-indene-4-carboxylate
• CAS: 71042-72-3
• 化学式: C₁₃H₁₆O₂
• 分子量: 204.269
• InChiKey: ZZUHUGVNICWMQB-UHFFFAOYSA-N

物化性质

• 沸点：
  110-112 °C(Press: 0.45 Torr)
• 密度：
  1.079±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2916399090

反应信息

• 作为反应物：
  描述：

  2,3-二氢-7-甲基-1H-茚-4-羧酸乙酯 在 氢氧化钾 、 氯化亚砜 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成 2,3-二氢-7-甲基-1H-茚-4-甲酰氯
  参考文献：
  名称：

  Improved synthesis of 3-methylcholanthrene

  摘要：

  DOI：

  10.1021/jo00330a008
• 作为产物：
  描述：

  2,3,7,7a-四氢-7-甲基-1H-茚-4-羧酸乙酯 以60%的产率得到
  参考文献：
  名称：

  TANG PING WAH; MAGGIULLI C. A., J. ORG. CHEM., 1981, 46, NO 17, 3429-3432

  摘要：

  DOI：

文献信息

• C-glucoside derivative containing fused phenyl ring or pharmaceutically acceptable salt thereof, process for preparing same, and pharmaceutical composition comprising same
  申请人：Je II Pharmaceutical Co., Ltd.

  公开号：US10752604B2

  公开（公告）日：2020-08-25

  The present disclosure relates to C-glycoside derivatives having a fused phenyl ring or pharmaceutical acceptable salts thereof, a method for preparing the same, a pharmaceutical composition comprising the same, a use thereof and a method for dual inhibition of SGLT1 and SGLT2 using the same. A novel compound of the present disclosure has a dual inhibitory activity against SGLT1 and SGLT2, thus being valuably used as a diabetes therapeutic agent.

  本公开涉及具有融合苯基环的 C-糖苷衍生物或其药物可接受盐、制备方法、包含其的药物组合物、其用途以及使用其对 SGLT1 和 SGLT2 进行双重抑制的方法。本公开的一种新型化合物具有对 SGLT1 和 SGLT2 的双重抑制活性，因此可用作糖尿病治疗剂。
• C-GLUCOSIDE DERIVATIVE CONTAINING FUSED PHENYL RING OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
  申请人：Jeil Pharmaceutical Co., Ltd.

  公开号：EP3404033B1

  公开（公告）日：2020-08-05
• C-Glucoside Derivative Containing Fused Phenyl Ring or Pharmaceutically Acceptable Salt Thereof, Process for Preparing Same, and Pharmaceutical Composition Comprising Same
  申请人：Je Il Pharmaceutical Co., Ltd.

  公开号：US20190002425A1

  公开（公告）日：2019-01-03

  The present disclosure relates to C-glycoside derivatives having a fused phenyl ring or pharmaceutical acceptable salts thereof, a method for preparing the same, a pharmaceutical composition comprising the same, a use thereof and a method for dual inhibition of SGLT1 and SGLT2 using the same. A novel compound of the present disclosure has a dual inhibitory activity against SGLT1 and SGLT2, thus being valuably used as a diabetes therapeutic agent.
• [EN] C-GLUCOSIDE DERIVATIVE CONTAINING FUSED PHENYL RING OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME<br/>[FR] DÉRIVÉ DE C-GLUCOSIDE CONTENANT UN CYCLE PHÉNYLE CONDENSÉ OU SON SEL PHARMACEUTIQUEMENT ACCEPTABLE, SON PROCÉDÉ DE PRÉPARATION ET COMPOSITION PHARMACEUTIQUE LE COMPRENANT<br/>[KO] 융합 페닐 환이 포함된 C-글루코시드 유도체 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 포함하는 약학적 조성물
  申请人：JE IL PHARMACEUTICAL CO LTD

  公开号：WO2017119700A1

  公开（公告）日：2017-07-13

  본 발명은 융합 페닐 환이 포함된 C-글루코시드 유도체 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법, 이를 포함하는 약학적 조성물, 이의 용도 및 이를 이용한 SGLT1 및 SGLT2의 이중 억제 방법에 관한 것이다. 본 발명의 신규 화합물은 SGLT1 및 SGLT2의 이중 억제 활성이 있으므로 당뇨병 치료제로서 유용하게 사용될 수 있다.
• NOVEL BICYCLIC-CARBOXAMIDE COMPOUNDS USEFUL AS PESTICIDES
  申请人：[en]SYNGENTA CROP PROTECTION AG

  公开号：WO2024126650A1

  公开（公告）日：2024-06-20

  Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers, or N-oxides of those compounds, can be used as insecticides.