2-ethyl-butyric acid diethylamide | 79868-38-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-ethyl-butyric acid diethylamide
• 英文别名: Diaethylessigsaeure-diaethylamid；2-Aethyl-buttersaeure-diaethylamid；N,N,2-triethyl-butanamide；N,N,2-triethylbutanamide
• CAS: 79868-38-5
• 化学式: C₁₀H₂₁NO
• 分子量: 171.283
• InChiKey: KLVRKNJSKXACLQ-UHFFFAOYSA-N

物化性质

• 沸点：
  220.5±0.0 °C(Predicted)
• 密度：
  0.863±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-ethyl-butyric acid diethylamide 、 苯基锂 在 lanthanum(lll) triflate 作用下， 生成 2-乙基-1,1-二苯基丁醇 、 2-乙基苯丁酮
  参考文献：
  名称：

  Additions of alkyllathanum triflates to carbonyl compounds: reactive organometallic nucleophiles

  摘要：

  DOI：

  10.1021/jo00298a035
• 作为产物：
  描述：

  2-乙基丁酰氯 、 二乙胺 生成 2-ethyl-butyric acid diethylamide
  参考文献：
  名称：

  DE168451

  摘要：

  公开号：

文献信息

• TRIFLUOROMETHYLTHIOPHENIUM DERIVATIVE SALT, METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING TRIFLUOROMETHYL-CONTAINING COMPOUNDS USING THE SAME
  申请人：Shibata Norio

  公开号：US20120130090A1

  公开（公告）日：2012-05-24

  A trifluoromethylthiophenium derivative salt useful as synthetic intermediates for pharmaceuticals and agrochemicals, a method for producing the same, and a method for producing trifluoromethyl-containing compounds using the same are provided. An S-(trifluoromethyl)-benzo[b]thiophenium derivative salt is represented by the following general formula (1): wherein R 1 , R 2 , R 3 , and R 4 are each independently a hydrogen atom, a methyl group, an ethyl group, a linear, branched, or cyclic alkyl group having 3 to 10 carbon atoms, a methoxy group, an ethoxy group, a linear, branched, or cyclic alkyloxy group having 3 to 10 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, a nitro group, or a cyano group, R 5 is a methyl group, an ethyl group, a linear, branched, or cyclic alkyl group having 3 to 10 carbon atoms, a phenyl group, or a substituted phenyl group, and X − represents an anion. Various trifluoromethyl-containing compounds are produced using a method for producing the S-(trifluoromethyl)-benzo[b]thiophenium derivative salt, and using the S-(trifluoromethyl)-benzo[b]thiophenium derivative salt as a trifluoromethylating agent.

  本发明提供一种三氟甲基噻吩盐衍生物，可用作制药和农药的合成中间体，以及其制备方法和使用该盐衍生物制备含三氟甲基化合物的方法。S-(三氟甲基)-苯并[b]噻吩盐衍生物由下列普通式（1）表示：其中，R1、R2、R3和R4各自独立地是氢原子、甲基基团、乙基基团、具有3至10个碳原子的线性、支链或环烷基基团、甲氧基基团、乙氧基基团、具有3至10个碳原子的线性、支链或环烷氧基基团、氟原子、氯原子、溴原子、硝基或氰基，R5是甲基基团、乙基基团、具有3至10个碳原子的线性、支链或环烷基基团、苯基或取代苯基，X-表示阴离子。使用制备S-(三氟甲基)-苯并[b]噻吩盐衍生物的方法以及使用S-(三氟甲基)-苯并[b]噻吩盐衍生物作为三氟甲基化试剂可以制备各种三氟甲基含量的化合物。
• Composition providing a cooling sensation substantially similar to that provided by menthol
  申请人：Kraft Foods Global Brands LLC

  公开号：EP2478777A1

  公开（公告）日：2012-07-25

  A composition is provided that may be delivered orally or to the skin or mucous membranes and that provides substantially the same physiological effect as menthol but does not contain menthol at all or in an amount that is less than normally is required to deliver the same physiological effect. The description extends to products suitable for oral, skin or mucosal delivery that impart a menthol-like sensation and that contain the compositions described therein. Particular of these products include chewing gums and confections. Further, the description embraces methods of providing a physiological sensation substantially similar to that imparted by menthol alone by administering a composition as described herein or a product containing such a composition. Still further, the description extends to methods for providing a physiological sensation substantially similar to one aspect of the physiological sensation imparted by menthol alone or heightened or reduced when compared to menthol alone.

  本发明提供了一种可口服或皮肤或粘膜给药的组合物，该组合物具有与薄荷醇基本相同的生理效应，但完全不含薄荷醇，或其含量低于通常情况下产生相同生理效应所需的量。本说明适用于口腔、皮肤或粘膜给药的产品，这些产品可提供类似薄荷醇的感觉，并含有其中所述的成分。这些产品包括口香糖和糖果。此外，所述内容还包括通过施用本文所述的组合物或含有此类组合物的产品来提供与薄荷醇单独产生的感觉基本相似的生理感觉的方法。更进一步，所述内容还包括提供生理感觉的方法，这种生理感觉与单独使用薄荷醇所产生的生理感觉的一个方面基本相似，或者与单独使用薄荷醇相比有所增强或减弱。
• TRIFLUOROMETHYLTHIOPHENIUM DERIVATIVE SALTS, PROCESS FOR PRODUCITON THEREOF, AND PROCESS FOR PRODUCTION OF TRIFLUOROMETHYL-CONTAINING COMPOUNDS USING SAME
  申请人：Nagoya Institute of Technology

  公开号：EP2460802A1

  公开（公告）日：2012-06-06

  A trifluoromethylthiophenium derivative salt useful as synthetic intermediates for pharmaceuticals and agrochemicals, a method for producing the same, and a method for producing trifluoromethyl-containing compounds using the same are provided. An S-(trifluoromethyl)-benzo[b]thiophenium derivative salt is represented by the following general formula (1): wherein R1, R2, R3, and R4 are each independently a hydrogen atom, a methyl group, an ethyl group, a linear, branched, or cyclic alkyl group having 3 to 10 carbon atoms, a methoxy group, an ethoxy group, a linear, branched, or cyclic alkyloxy group having 3 to 10 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, a nitro group, or a cyano group, R5 is a methyl group, an ethyl group, a linear, branched, or cyclic alkyl group having 3 to 10 carbon atoms, a phenyl group, or a substituted phenyl group, and X- represents an anion. Various trifluoromethyl-containing compounds are produced using a method for producing the S-(trifluoromethyl)-benzo[b]thiophenium derivative salt, and using the S-(trifluoromethyl)-benzo[b]thiophenium derivative salt as a trifluoromethylating agent.

  本发明提供了一种可用作医药和农用化学品合成中间体的三氟甲基噻吩衍生物盐、生产该衍生物盐的方法以及使用该衍生物盐生产含三氟甲基化合物的方法。一种 S-(三氟甲基)-苯并[b]噻吩衍生物盐由以下通式(1)表示： 其中 R1、R2、R3 和 R4 各自独立地为氢原子、甲基、乙基、具有 3 至 10 个碳原子的直链、支链或环状烷基、甲氧基、乙氧基、具有 3 至 10 个碳原子的直链、支链或环状烷氧基、氟原子、氯原子、溴原子、硝基或氰基，R5 是甲基、乙基、具有 3 至 10 个碳原子的直链、支链或环状烷基、苯基或取代苯基，X- 代表阴离子。使用生产 S-(三氟甲基)-苯并[b]噻吩衍生物盐的方法，并使用 S-(三氟甲基)-苯并[b]噻吩衍生物盐作为三氟甲基化剂，可生产出各种含三氟甲基的化合物。
• Cooling composition comprising trimethyl isopropyl butanamide
  申请人：Kraft Foods Global Brands LLC

  公开号：EP2559424A1

  公开（公告）日：2013-02-20

  This description provides cooling compositions that deliver a prolonged physiological cooling sensation to the skin or a mucous membrane. The cooling compositions may be present alone or in product such as a chewing gum or a confection. The cooling compositions comprise a menthyl ester and a second cooling agent, which may be WS-3 or WS-23 and optionally menthol. The menthyl ester may be a menthyl glutarate or a menthyl succinate ester, and it may be present in an amount of at least 5 weight percentage, at least 10 weight percentage, at least 20 weight percentage, at least 30 weight percentage, or at least 40 weight percentage. In many instances, the menthyl ester is present in an amount of 5 to 60 weight percentage or especially 15 to 50 wt %.

  本说明提供的降温组合物可为皮肤或粘膜带来长时间的生理降温感觉。这种降温组合物可以单独使用，也可以与口香糖或糖果等产品一起使用。降温组合物由薄荷酯和第二种降温剂组成，第二种降温剂可以是 WS-3 或 WS-23，也可以是薄荷醇。薄荷酯可以是戊二酸薄荷酯或琥珀酸薄荷酯，其含量可以是至少 5 重量百分比、至少 10 重量百分比、至少 20 重量百分比、至少 30 重量百分比或至少 40 重量百分比。在许多情况下，薄荷酯的含量为 5 至 60 重量百分比，特别是 15 至 50 重量百分比。
• Einhorn, Justus Liebigs Annalen der Chemie, 1908, vol. 359, p. 184
  作者：Einhorn

  DOI：——

  日期：——