tert-butyl N,N-diethyl-N'-[(4-phenyl)thiazol-2-yl]phosphorodiamidite | 913055-89-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: tert-butyl N,N-diethyl-N'-[(4-phenyl)thiazol-2-yl]phosphorodiamidite
• 英文别名: tert-butyl N,N-diethyl-N'-(4-phenylthiazol-2-yl)phosphorodiamidite
• CAS: 913055-89-7
• 化学式: C₁₇H₂₆N₃OPS
• 分子量: 351.453
• InChiKey: LXQKCVOISICSSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.61
• 重原子数：
  23.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  37.39
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  tert-butyl N,N-diethyl-N'-[(4-phenyl)thiazol-2-yl]phosphorodiamidite 在 三乙胺 作用下， 生成 [(diethylamino)[(4-phenylthiazol-2-yl)amino]phosphinoyl](methylene)methyl acetate
  参考文献：
  名称：

  New synthetic approach to phosphorylated 2-aminothiazoles

  摘要：

  DOI：

  10.1134/s1070363207020211
• 作为产物：
  描述：

  2-氨基-4-苯基噻唑 、 二-(二乙基氨基)-叔丁氧基膦 以 乙酸乙酯 为溶剂， 以85%的产率得到tert-butyl N,N-diethyl-N'-[(4-phenyl)thiazol-2-yl]phosphorodiamidite
  参考文献：
  名称：

  New Amidoesters of P(III) Acids on the Basis of 2-Amino-4-phenylthiazole

  摘要：

  DOI：

  10.1007/s11176-006-0027-x

文献信息

• Reactions of tert-butyl N,N-diethyl-N′-(4-phenylthiazol-2-yl)-phosphorodiamidite with electrophilic reagents
  作者：L. K. Sal’keeva、M. T. Nurmaganbetova、E. V. Minaeva、B. Z. Kokzhalova

  DOI：10.1134/s1070363206090076

  日期：2006.9

  Previously unknown amidophosphorous acid derivatives were prepared by transamidation of tert-butyl N,N-diethyl-N'-(4-phenylthiazolyl)phosphorodiamidite with 2-amino-4-phenylthiazole, and their reactions with acetyl and benzoyl chloride were studied. These reactions are shown to proceed regioselectively according to the Arbuzov scheme to give the corresponding ketophosphonates. The reaction of the phosphorodiamidite with acetyl chloride in a I : 2 molar ratio involves formation of acetophosphonate that reacts in the enol form to give the corresponding (1-acetoxy)vinylphosphonate.
• Glycidol esters from diethylamido-(4-phenylthiazolyl-2-amido)-ketophosphonates and their chemical modification
  作者：L. K. Sal’keeva、E. V. Minayeva、M. T. Nurmaganbetova、B. Z. Kokzhalova、A. I. Mantel’

  DOI：10.1134/s1070363209040136

  日期：2009.4

  Thiazolyl-containing esters of alpha-ketophosphonic acids (KPE) unknown earlier were synthesized and investigated in Darzens-Claisen reaction. Reactions were demonstrated to proceed by a classic scheme to form the corresponding phosphorylated glycidol esters whose alkaline hydrolysis gave rise to phosphorylated aldehydes of interesting nature.