Boc-Met-Leu-gPhe-COOMe

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Met-Leu-gPhe-COOMe
• 英文别名: tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R)-1-(methoxycarbonylamino)-2-phenylethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]carbamate
• 化学式: C₂₆H₄₂N₄O₆S
• 分子量: 538.709
• InChiKey: JNCUQWKRKMYOAI-PCCBWWKXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  37
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  160
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  Boc-Leu-gPhe-COOMe 在 N-甲基吗啉 、 甲醇 、 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 27.0h， 生成 Boc-Met-Leu-gPhe-COOMe
  参考文献：
  名称：

  Biscarbamate analogues of the chemotactic tripeptide fMLFOMe

  摘要：

  Based on the sequence of the prototypical chemotactic tripeptide HCO-Met-Leu-Phe-OH (fMLF) and by taking into account the versatility shown by its N-terminal carbamate analogues, the new biscarbamates MeOCO-Met-Leu-gPhe-COOMe (2) and Boc-Met-Leu-gPhe-COOMe (4) were synthesized. These two new ligands are characterized by the presence of a gem-diamino residue (gPhe) replacing the C-terminal Phe and a carbamate functionality positioned at both the ends of the molecule. The activity of the two new compounds has been determined on human neutrophils and compared to that shown by the corresponding N-terminal monocarbamates MeOCO-Met-Leu-Phe-OMe (1) and Boc-Met-Leu-Phe-OMe (3).

  DOI：

  10.1016/s0014-827x(00)00045-8

文献信息

• Biscarbamate analogues of the chemotactic tripeptide fMLFOMe
  作者：Giampiero Pagani Zecchini、Mario Paglialunga Paradisi、Ines Torrini、Marianna Nalli、Gino Lucente、Susanna Spisani

  DOI：10.1016/s0014-827x(00)00045-8

  日期：2000.4

  Based on the sequence of the prototypical chemotactic tripeptide HCO-Met-Leu-Phe-OH (fMLF) and by taking into account the versatility shown by its N-terminal carbamate analogues, the new biscarbamates MeOCO-Met-Leu-gPhe-COOMe (2) and Boc-Met-Leu-gPhe-COOMe (4) were synthesized. These two new ligands are characterized by the presence of a gem-diamino residue (gPhe) replacing the C-terminal Phe and a carbamate functionality positioned at both the ends of the molecule. The activity of the two new compounds has been determined on human neutrophils and compared to that shown by the corresponding N-terminal monocarbamates MeOCO-Met-Leu-Phe-OMe (1) and Boc-Met-Leu-Phe-OMe (3).